Compact Optical Nerve Cuff Electrode for Simultaneous Neural Activity Monitoring and Optogenetic Stimulation of Peripheral Nerves

Abstract Optogenetic stimulation of the peripheral nervous system is a novel approach to motor control, somatosensory transduction, and pain processing. Various optical stimulation tools have been developed for optogenetic stimulation using optical fibers and light-emitting diodes positioned on the...

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Autores principales:	Kang-Il Song, Sunghee Estelle Park, Seul Lee, Hyungmin Kim, Soo Hyun Lee, Inchan Youn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Nerve Cuff Electrode Optogenetic Stimulation Optical Stimulation PDMS Substrate Record Neural Signals Medicine R Science Q
Acceso en línea:	https://doaj.org/article/02c3524db78340f699bee6d4f976cca5
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spelling	oai:doaj.org-article:02c3524db78340f699bee6d4f976cca52021-12-02T15:08:38ZCompact Optical Nerve Cuff Electrode for Simultaneous Neural Activity Monitoring and Optogenetic Stimulation of Peripheral Nerves10.1038/s41598-018-33695-22045-2322https://doaj.org/article/02c3524db78340f699bee6d4f976cca52018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33695-2https://doaj.org/toc/2045-2322Abstract Optogenetic stimulation of the peripheral nervous system is a novel approach to motor control, somatosensory transduction, and pain processing. Various optical stimulation tools have been developed for optogenetic stimulation using optical fibers and light-emitting diodes positioned on the peripheral nerve. However, these tools require additional sensors to monitor the limb or muscle status. We present herein a novel optical nerve cuff electrode that uses a single cuff electrode to conduct to simultaneously monitor neural activity and optogenetic stimulation of the peripheral nerve. The proposed optical nerve cuff electrode is designed with a polydimethylsiloxane substrate, on which electrodes can be positioned to record neural activity. We confirm that the illumination intensity and the electrical properties of the optical nerve cuff electrode are suitable for optical stimulation with simultaneous neural activity monitoring in Thy1::ChR2 transgenic mice. With the proposed electrode, the limb status is monitored with continuous streaming signals during the optical stimulation of anesthetized and moving animals. In conclusion, this optical nerve cuff electrode provides a new optical modulation tool for peripheral nervous system studies.Kang-Il SongSunghee Estelle ParkSeul LeeHyungmin KimSoo Hyun LeeInchan YounNature PortfolioarticleNerve Cuff ElectrodeOptogenetic StimulationOptical StimulationPDMS SubstrateRecord Neural SignalsMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nerve Cuff Electrode Optogenetic Stimulation Optical Stimulation PDMS Substrate Record Neural Signals Medicine R Science Q
spellingShingle	Nerve Cuff Electrode Optogenetic Stimulation Optical Stimulation PDMS Substrate Record Neural Signals Medicine R Science Q Kang-Il Song Sunghee Estelle Park Seul Lee Hyungmin Kim Soo Hyun Lee Inchan Youn Compact Optical Nerve Cuff Electrode for Simultaneous Neural Activity Monitoring and Optogenetic Stimulation of Peripheral Nerves
description	Abstract Optogenetic stimulation of the peripheral nervous system is a novel approach to motor control, somatosensory transduction, and pain processing. Various optical stimulation tools have been developed for optogenetic stimulation using optical fibers and light-emitting diodes positioned on the peripheral nerve. However, these tools require additional sensors to monitor the limb or muscle status. We present herein a novel optical nerve cuff electrode that uses a single cuff electrode to conduct to simultaneously monitor neural activity and optogenetic stimulation of the peripheral nerve. The proposed optical nerve cuff electrode is designed with a polydimethylsiloxane substrate, on which electrodes can be positioned to record neural activity. We confirm that the illumination intensity and the electrical properties of the optical nerve cuff electrode are suitable for optical stimulation with simultaneous neural activity monitoring in Thy1::ChR2 transgenic mice. With the proposed electrode, the limb status is monitored with continuous streaming signals during the optical stimulation of anesthetized and moving animals. In conclusion, this optical nerve cuff electrode provides a new optical modulation tool for peripheral nervous system studies.
format	article
author	Kang-Il Song Sunghee Estelle Park Seul Lee Hyungmin Kim Soo Hyun Lee Inchan Youn
author_facet	Kang-Il Song Sunghee Estelle Park Seul Lee Hyungmin Kim Soo Hyun Lee Inchan Youn
author_sort	Kang-Il Song
title	Compact Optical Nerve Cuff Electrode for Simultaneous Neural Activity Monitoring and Optogenetic Stimulation of Peripheral Nerves
title_short	Compact Optical Nerve Cuff Electrode for Simultaneous Neural Activity Monitoring and Optogenetic Stimulation of Peripheral Nerves
title_full	Compact Optical Nerve Cuff Electrode for Simultaneous Neural Activity Monitoring and Optogenetic Stimulation of Peripheral Nerves
title_fullStr	Compact Optical Nerve Cuff Electrode for Simultaneous Neural Activity Monitoring and Optogenetic Stimulation of Peripheral Nerves
title_full_unstemmed	Compact Optical Nerve Cuff Electrode for Simultaneous Neural Activity Monitoring and Optogenetic Stimulation of Peripheral Nerves
title_sort	compact optical nerve cuff electrode for simultaneous neural activity monitoring and optogenetic stimulation of peripheral nerves
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/02c3524db78340f699bee6d4f976cca5
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Compact Optical Nerve Cuff Electrode for Simultaneous Neural Activity Monitoring and Optogenetic Stimulation of Peripheral Nerves

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