EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup>+</sup>CD45RО<sup>+</sup>/CD8<sup>+</sup>CD45RО<sup>+</sup> T CELLS
Effect of γс-cytokines (IL-2, IL-7 и IL-15) upon maturation and differentiation of cytotoxic and helper CD45RО+ Tcell population was studied in the homeostatic in vitro culture conditions. We have found that IL-2, IL-7 and IL-15 mediate maturation and differentiation of CD8 T cells central memory, r...
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oai:doaj.org-article:02c48b2b988145c8b7911886c407c9fc2021-11-18T08:03:46ZEFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup>+</sup>CD45RО<sup>+</sup>/CD8<sup>+</sup>CD45RО<sup>+</sup> T CELLS1563-06252313-741X10.15789/1563-0625-2018-1-45-52https://doaj.org/article/02c48b2b988145c8b7911886c407c9fc2018-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1431https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XEffect of γс-cytokines (IL-2, IL-7 и IL-15) upon maturation and differentiation of cytotoxic and helper CD45RО+ Tcell population was studied in the homeostatic in vitro culture conditions. We have found that IL-2, IL-7 and IL-15 mediate maturation and differentiation of CD8 T cells central memory, replenishing the population of cells that exhibit effector functions. Action of IL-2 on CD4+ central memory T cells is accociated with generation of effector memory cells by reducing the number of immature effectors (CD62L–CD27+), whereas IL-7 promotes the formation of immature (CD62L–CD27+) effectors. IL-2, IL-7 and IL-15 initiate formation of terminally-differentiated cells in a subpopulation of CD8+CD45RO+ lymphocytes, providing a stable immunological memory to a pathogen reinfestation.K. A. YurovaO. G. KhaziakhmatovaN. M. TodosenkoL. S. LitvinovaSPb RAACIarticleimmunological memorycentral memory t cellseffector memory t cellsterminally differentiated cellsγc-cytokinesdifferentiationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 1, Pp 45-52 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
RU |
| topic |
immunological memory central memory t cells effector memory t cells terminally differentiated cells γc-cytokines differentiation Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
immunological memory central memory t cells effector memory t cells terminally differentiated cells γc-cytokines differentiation Immunologic diseases. Allergy RC581-607 K. A. Yurova O. G. Khaziakhmatova N. M. Todosenko L. S. Litvinova EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup>+</sup>CD45RО<sup>+</sup>/CD8<sup>+</sup>CD45RО<sup>+</sup> T CELLS |
| description |
Effect of γс-cytokines (IL-2, IL-7 и IL-15) upon maturation and differentiation of cytotoxic and helper CD45RО+ Tcell population was studied in the homeostatic in vitro culture conditions. We have found that IL-2, IL-7 and IL-15 mediate maturation and differentiation of CD8 T cells central memory, replenishing the population of cells that exhibit effector functions. Action of IL-2 on CD4+ central memory T cells is accociated with generation of effector memory cells by reducing the number of immature effectors (CD62L–CD27+), whereas IL-7 promotes the formation of immature (CD62L–CD27+) effectors. IL-2, IL-7 and IL-15 initiate formation of terminally-differentiated cells in a subpopulation of CD8+CD45RO+ lymphocytes, providing a stable immunological memory to a pathogen reinfestation. |
| format |
article |
| author |
K. A. Yurova O. G. Khaziakhmatova N. M. Todosenko L. S. Litvinova |
| author_facet |
K. A. Yurova O. G. Khaziakhmatova N. M. Todosenko L. S. Litvinova |
| author_sort |
K. A. Yurova |
| title |
EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup>+</sup>CD45RО<sup>+</sup>/CD8<sup>+</sup>CD45RО<sup>+</sup> T CELLS |
| title_short |
EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup>+</sup>CD45RО<sup>+</sup>/CD8<sup>+</sup>CD45RО<sup>+</sup> T CELLS |
| title_full |
EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup>+</sup>CD45RО<sup>+</sup>/CD8<sup>+</sup>CD45RО<sup>+</sup> T CELLS |
| title_fullStr |
EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup>+</sup>CD45RО<sup>+</sup>/CD8<sup>+</sup>CD45RО<sup>+</sup> T CELLS |
| title_full_unstemmed |
EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4<sup>+</sup>CD45RО<sup>+</sup>/CD8<sup>+</sup>CD45RО<sup>+</sup> T CELLS |
| title_sort |
effects of γс-cytokines (il-2, il-7 and il-15) upon in vitro maturation and differentiation of cd4<sup>+</sup>cd45rо<sup>+</sup>/cd8<sup>+</sup>cd45rо<sup>+</sup> t cells |
| publisher |
SPb RAACI |
| publishDate |
2018 |
| url |
https://doaj.org/article/02c48b2b988145c8b7911886c407c9fc |
| work_keys_str_mv |
AT kayurova effectsofgscytokinesil2il7andil15uponinvitromaturationanddifferentiationofcd4supsupcd45rosupsupcd8supsupcd45rosupsuptcells AT ogkhaziakhmatova effectsofgscytokinesil2il7andil15uponinvitromaturationanddifferentiationofcd4supsupcd45rosupsupcd8supsupcd45rosupsuptcells AT nmtodosenko effectsofgscytokinesil2il7andil15uponinvitromaturationanddifferentiationofcd4supsupcd45rosupsupcd8supsupcd45rosupsuptcells AT lslitvinova effectsofgscytokinesil2il7andil15uponinvitromaturationanddifferentiationofcd4supsupcd45rosupsupcd8supsupcd45rosupsuptcells |
| _version_ |
1718422393915965440 |