Multi-scaled Monte Carlo calculation for radon-induced cellular damage in the bronchial airway epithelium

Abstract Radon is a leading cause of lung cancer in indoor public and mining workers. Inhaled radon progeny releases alpha particles, which can damage cells in the airway epithelium. The extent and complexity of cellular damage vary depending on the alpha particle’s kinetic energy and cell character...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ali Abu Shqair, Eun-Hee Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/02c90f9c5d7d4dc6bc277cea9394e4c9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:02c90f9c5d7d4dc6bc277cea9394e4c9
record_format	dspace
spelling	oai:doaj.org-article:02c90f9c5d7d4dc6bc277cea9394e4c92021-12-02T15:55:13ZMulti-scaled Monte Carlo calculation for radon-induced cellular damage in the bronchial airway epithelium10.1038/s41598-021-89689-02045-2322https://doaj.org/article/02c90f9c5d7d4dc6bc277cea9394e4c92021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89689-0https://doaj.org/toc/2045-2322Abstract Radon is a leading cause of lung cancer in indoor public and mining workers. Inhaled radon progeny releases alpha particles, which can damage cells in the airway epithelium. The extent and complexity of cellular damage vary depending on the alpha particle’s kinetic energy and cell characteristics. We developed a framework to quantitate the cellular damage on the nanometer and micrometer scales at different intensities of exposure to radon progenies Po-218 and Po-214. Energy depositions along the tracks of alpha particles that were slowing down were simulated on a nanometer scale using the Monte Carlo code Geant4-DNA. The nano-scaled track histories in a 5 μm radius and 1 μm-thick cylindrical volume were integrated into the tracking scheme of alpha trajectories in a micron-scale bronchial epithelium segment in the user-written SNU-CDS program. Damage distribution in cellular DNA was estimated for six cell types in the epithelium. Deep-sited cell nuclei in the epithelium would have less chance of being hit, but DNA damage from a single hit would be more serious, because low-energy alpha particles of high LET would hit the nuclei. The greater damage in deep-sited nuclei was due to the 7.69 MeV alpha particles emitted from Po-214. From daily work under 1 WL of radon concentration, basal cells would respond with the highest portion of complex DSBs among the suspected progenitor cells in the most exposed regions of the lung epithelium.Ali Abu ShqairEun-Hee KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ali Abu Shqair Eun-Hee Kim Multi-scaled Monte Carlo calculation for radon-induced cellular damage in the bronchial airway epithelium
description	Abstract Radon is a leading cause of lung cancer in indoor public and mining workers. Inhaled radon progeny releases alpha particles, which can damage cells in the airway epithelium. The extent and complexity of cellular damage vary depending on the alpha particle’s kinetic energy and cell characteristics. We developed a framework to quantitate the cellular damage on the nanometer and micrometer scales at different intensities of exposure to radon progenies Po-218 and Po-214. Energy depositions along the tracks of alpha particles that were slowing down were simulated on a nanometer scale using the Monte Carlo code Geant4-DNA. The nano-scaled track histories in a 5 μm radius and 1 μm-thick cylindrical volume were integrated into the tracking scheme of alpha trajectories in a micron-scale bronchial epithelium segment in the user-written SNU-CDS program. Damage distribution in cellular DNA was estimated for six cell types in the epithelium. Deep-sited cell nuclei in the epithelium would have less chance of being hit, but DNA damage from a single hit would be more serious, because low-energy alpha particles of high LET would hit the nuclei. The greater damage in deep-sited nuclei was due to the 7.69 MeV alpha particles emitted from Po-214. From daily work under 1 WL of radon concentration, basal cells would respond with the highest portion of complex DSBs among the suspected progenitor cells in the most exposed regions of the lung epithelium.
format	article
author	Ali Abu Shqair Eun-Hee Kim
author_facet	Ali Abu Shqair Eun-Hee Kim
author_sort	Ali Abu Shqair
title	Multi-scaled Monte Carlo calculation for radon-induced cellular damage in the bronchial airway epithelium
title_short	Multi-scaled Monte Carlo calculation for radon-induced cellular damage in the bronchial airway epithelium
title_full	Multi-scaled Monte Carlo calculation for radon-induced cellular damage in the bronchial airway epithelium
title_fullStr	Multi-scaled Monte Carlo calculation for radon-induced cellular damage in the bronchial airway epithelium
title_full_unstemmed	Multi-scaled Monte Carlo calculation for radon-induced cellular damage in the bronchial airway epithelium
title_sort	multi-scaled monte carlo calculation for radon-induced cellular damage in the bronchial airway epithelium
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/02c90f9c5d7d4dc6bc277cea9394e4c9
work_keys_str_mv	AT aliabushqair multiscaledmontecarlocalculationforradoninducedcellulardamageinthebronchialairwayepithelium AT eunheekim multiscaledmontecarlocalculationforradoninducedcellulardamageinthebronchialairwayepithelium
_version_	1718385369481740288

Multi-scaled Monte Carlo calculation for radon-induced cellular damage in the bronchial airway epithelium

Ejemplares similares