Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease
Inflammatory bowel diseases are heterogeneous, and little is known about how underlying genetic variation can affect their development. Here, the authors report that intestinal inflammation modulates the effect of host genetics on the gut mucosal expression of 190 genes in the context of inflammator...
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Nature Portfolio
2021
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oai:doaj.org-article:02cc8b0b815a4d49ba031137f6cb44b32021-12-02T14:21:27ZInflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease10.1038/s41467-021-21458-z2041-1723https://doaj.org/article/02cc8b0b815a4d49ba031137f6cb44b32021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21458-zhttps://doaj.org/toc/2041-1723Inflammatory bowel diseases are heterogeneous, and little is known about how underlying genetic variation can affect their development. Here, the authors report that intestinal inflammation modulates the effect of host genetics on the gut mucosal expression of 190 genes in the context of inflammatory bowel diseases.Shixian HuWerna T. Uniken VenemaHarm-Jan WestraArnau Vich VilaRuggero BarbieriMichiel D. VoskuilTjasso BlokzijlBernadien H. JansenYanni LiMark J. DalyRamnik J. XavierGerard DijkstraEleonora A. FestenRinse K. WeersmaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Shixian Hu Werna T. Uniken Venema Harm-Jan Westra Arnau Vich Vila Ruggero Barbieri Michiel D. Voskuil Tjasso Blokzijl Bernadien H. Jansen Yanni Li Mark J. Daly Ramnik J. Xavier Gerard Dijkstra Eleonora A. Festen Rinse K. Weersma Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease |
| description |
Inflammatory bowel diseases are heterogeneous, and little is known about how underlying genetic variation can affect their development. Here, the authors report that intestinal inflammation modulates the effect of host genetics on the gut mucosal expression of 190 genes in the context of inflammatory bowel diseases. |
| format |
article |
| author |
Shixian Hu Werna T. Uniken Venema Harm-Jan Westra Arnau Vich Vila Ruggero Barbieri Michiel D. Voskuil Tjasso Blokzijl Bernadien H. Jansen Yanni Li Mark J. Daly Ramnik J. Xavier Gerard Dijkstra Eleonora A. Festen Rinse K. Weersma |
| author_facet |
Shixian Hu Werna T. Uniken Venema Harm-Jan Westra Arnau Vich Vila Ruggero Barbieri Michiel D. Voskuil Tjasso Blokzijl Bernadien H. Jansen Yanni Li Mark J. Daly Ramnik J. Xavier Gerard Dijkstra Eleonora A. Festen Rinse K. Weersma |
| author_sort |
Shixian Hu |
| title |
Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease |
| title_short |
Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease |
| title_full |
Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease |
| title_fullStr |
Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease |
| title_full_unstemmed |
Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease |
| title_sort |
inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/02cc8b0b815a4d49ba031137f6cb44b3 |
| work_keys_str_mv |
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