Ceftriaxone Mediated Synthesized Gold Nanoparticles: A Nano-Therapeutic Tool to Target Bacterial Resistance

Ceftriaxone has been a part of therapeutic regime for combating some of the most aggressive bacterial infections in the last few decades. However, increasing bacterial resistance towards ceftriaxone and other third generation cephalosporin antibiotics has raised serious clinical concerns especially...

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Autores principales:	Farhan Alshammari, Bushra Alshammari, Afrasim Moin, Abdulwahab Alamri, Turki Al Hagbani, Ahmed Alobaida, Abu Baker, Salman Khan, Syed Mohd Danish Rizvi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antibiotics antibacterial resistance ceftriaxone gold nanoparticles MIC<sub>50</sub> Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/02d262fd340e42ff9c33db15ce797a02
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spelling	oai:doaj.org-article:02d262fd340e42ff9c33db15ce797a022021-11-25T18:41:35ZCeftriaxone Mediated Synthesized Gold Nanoparticles: A Nano-Therapeutic Tool to Target Bacterial Resistance10.3390/pharmaceutics131118961999-4923https://doaj.org/article/02d262fd340e42ff9c33db15ce797a022021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1896https://doaj.org/toc/1999-4923Ceftriaxone has been a part of therapeutic regime for combating some of the most aggressive bacterial infections in the last few decades. However, increasing bacterial resistance towards ceftriaxone and other third generation cephalosporin antibiotics has raised serious clinical concerns especially due to their misuse in the COVID-19 era. Advancement in nanotechnology has converted nano-therapeutic vision into a plausible reality with better targeting and reduced drug consumption. Thus, in the present study, gold nanoparticles (GNPs) were synthesized by using ceftriaxone antibiotic that acts as a reducing as well as capping agent. Ceftriaxone-loaded GNPs (CGNPs) were initially characterized by UV-visible spectroscopy, DLS, Zeta potential, Electron microscopy and FT-IR. However, a TEM micrograph showed a uniform size of 21 ± 1 nm for the synthesized CGNPs. Further, both (CGNPs) and pure ceftriaxone were examined for their efficacy against <i>Escherichia coli</i>, <i>Staphylococcus aureus, Salmonella abony</i> and <i>Klebsiella pneumoniae</i>. CGNPs showed MIC<sub>50</sub> as 1.39, 1.6, 1.1 and 0.9 µg/mL against <i>E. coli</i>, <i>S. aureus</i>, <i>S. abony</i> and <i>K. pneumoniae</i>, respectively. Interestingly, CGNPs showed two times better efficacy when compared with pure ceftriaxone against the tested bacterial strains. Restoring the potential of unresponsive or less efficient ceftriaxone via gold nanoformulations is the most alluring concept of the whole study. Moreover, applicability of the findings from bench to bedside needs further validation.Farhan AlshammariBushra AlshammariAfrasim MoinAbdulwahab AlamriTurki Al HagbaniAhmed AlobaidaAbu BakerSalman KhanSyed Mohd Danish RizviMDPI AGarticleantibioticsantibacterial resistanceceftriaxonegold nanoparticlesMIC<sub>50</sub>Pharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1896, p 1896 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotics antibacterial resistance ceftriaxone gold nanoparticles MIC<sub>50</sub> Pharmacy and materia medica RS1-441
spellingShingle	antibiotics antibacterial resistance ceftriaxone gold nanoparticles MIC<sub>50</sub> Pharmacy and materia medica RS1-441 Farhan Alshammari Bushra Alshammari Afrasim Moin Abdulwahab Alamri Turki Al Hagbani Ahmed Alobaida Abu Baker Salman Khan Syed Mohd Danish Rizvi Ceftriaxone Mediated Synthesized Gold Nanoparticles: A Nano-Therapeutic Tool to Target Bacterial Resistance
description	Ceftriaxone has been a part of therapeutic regime for combating some of the most aggressive bacterial infections in the last few decades. However, increasing bacterial resistance towards ceftriaxone and other third generation cephalosporin antibiotics has raised serious clinical concerns especially due to their misuse in the COVID-19 era. Advancement in nanotechnology has converted nano-therapeutic vision into a plausible reality with better targeting and reduced drug consumption. Thus, in the present study, gold nanoparticles (GNPs) were synthesized by using ceftriaxone antibiotic that acts as a reducing as well as capping agent. Ceftriaxone-loaded GNPs (CGNPs) were initially characterized by UV-visible spectroscopy, DLS, Zeta potential, Electron microscopy and FT-IR. However, a TEM micrograph showed a uniform size of 21 ± 1 nm for the synthesized CGNPs. Further, both (CGNPs) and pure ceftriaxone were examined for their efficacy against <i>Escherichia coli</i>, <i>Staphylococcus aureus, Salmonella abony</i> and <i>Klebsiella pneumoniae</i>. CGNPs showed MIC<sub>50</sub> as 1.39, 1.6, 1.1 and 0.9 µg/mL against <i>E. coli</i>, <i>S. aureus</i>, <i>S. abony</i> and <i>K. pneumoniae</i>, respectively. Interestingly, CGNPs showed two times better efficacy when compared with pure ceftriaxone against the tested bacterial strains. Restoring the potential of unresponsive or less efficient ceftriaxone via gold nanoformulations is the most alluring concept of the whole study. Moreover, applicability of the findings from bench to bedside needs further validation.
format	article
author	Farhan Alshammari Bushra Alshammari Afrasim Moin Abdulwahab Alamri Turki Al Hagbani Ahmed Alobaida Abu Baker Salman Khan Syed Mohd Danish Rizvi
author_facet	Farhan Alshammari Bushra Alshammari Afrasim Moin Abdulwahab Alamri Turki Al Hagbani Ahmed Alobaida Abu Baker Salman Khan Syed Mohd Danish Rizvi
author_sort	Farhan Alshammari
title	Ceftriaxone Mediated Synthesized Gold Nanoparticles: A Nano-Therapeutic Tool to Target Bacterial Resistance
title_short	Ceftriaxone Mediated Synthesized Gold Nanoparticles: A Nano-Therapeutic Tool to Target Bacterial Resistance
title_full	Ceftriaxone Mediated Synthesized Gold Nanoparticles: A Nano-Therapeutic Tool to Target Bacterial Resistance
title_fullStr	Ceftriaxone Mediated Synthesized Gold Nanoparticles: A Nano-Therapeutic Tool to Target Bacterial Resistance
title_full_unstemmed	Ceftriaxone Mediated Synthesized Gold Nanoparticles: A Nano-Therapeutic Tool to Target Bacterial Resistance
title_sort	ceftriaxone mediated synthesized gold nanoparticles: a nano-therapeutic tool to target bacterial resistance
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/02d262fd340e42ff9c33db15ce797a02
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Ceftriaxone Mediated Synthesized Gold Nanoparticles: A Nano-Therapeutic Tool to Target Bacterial Resistance

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