Development of UV-Reactive Electrospinning Method Based on Poly(ethylene glycol) diacrylate Crosslinking

Electrospinning is a popular method for creating nonwoven fiber materials for a wide variety of applications. In the field of biomaterials, electrospun materials are favoured because of a high surface-to-volume ratio which can be useful for drug loading and release, and because nanoscale fibers mimi...

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Autores principales:	Huling Jennifer, Lyko Beate, Illner Sabine, Fiedler Nicklas, Grabow Niels, Teske Michael
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	reactive electrospinning pegda uv crosslinking Medicine R
Acceso en línea:	https://doaj.org/article/02d3ef70920248408744db0828e7d3cf
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spelling	oai:doaj.org-article:02d3ef70920248408744db0828e7d3cf2021-12-05T14:10:42ZDevelopment of UV-Reactive Electrospinning Method Based on Poly(ethylene glycol) diacrylate Crosslinking2364-550410.1515/cdbme-2020-3048https://doaj.org/article/02d3ef70920248408744db0828e7d3cf2020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3048https://doaj.org/toc/2364-5504Electrospinning is a popular method for creating nonwoven fiber materials for a wide variety of applications. In the field of biomaterials, electrospun materials are favoured because of a high surface-to-volume ratio which can be useful for drug loading and release, and because nanoscale fibers mimic native tissue structures, improving cell interactions. However limitations exist with regards to traditional solvent evaporation-based electrospinning techniques. A new area of research into reactive electrospinning is investigating methods of electrospinning that rely on in situ crosslinking rather than solvent evaporation to stabilize fibers. These techniques can potentially reduce the waste of excess solvents and make it easier to electrospin water soluble polymers. In this work, UV photocrosslinked PEGDA is evaluated as a material for reactive electrospinning. To facilitate the electrospinning process poly(ethylene glycol) diacrylate (PEGDA) is combined with polyvinyl alcohol (PVA). PEGDA/PVA solutions can be successfully electrospun under constant UV light exposure to initiate the crosslinking of the PEGDA. Reactive electrospun fibers appear more stable immediately after spinning and after washing with water, indicating successful photo crosslinking.Huling JenniferLyko BeateIllner SabineFiedler NicklasGrabow NielsTeske MichaelDe Gruyterarticlereactive electrospinningpegdauv crosslinkingMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 189-192 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	reactive electrospinning pegda uv crosslinking Medicine R
spellingShingle	reactive electrospinning pegda uv crosslinking Medicine R Huling Jennifer Lyko Beate Illner Sabine Fiedler Nicklas Grabow Niels Teske Michael Development of UV-Reactive Electrospinning Method Based on Poly(ethylene glycol) diacrylate Crosslinking
description	Electrospinning is a popular method for creating nonwoven fiber materials for a wide variety of applications. In the field of biomaterials, electrospun materials are favoured because of a high surface-to-volume ratio which can be useful for drug loading and release, and because nanoscale fibers mimic native tissue structures, improving cell interactions. However limitations exist with regards to traditional solvent evaporation-based electrospinning techniques. A new area of research into reactive electrospinning is investigating methods of electrospinning that rely on in situ crosslinking rather than solvent evaporation to stabilize fibers. These techniques can potentially reduce the waste of excess solvents and make it easier to electrospin water soluble polymers. In this work, UV photocrosslinked PEGDA is evaluated as a material for reactive electrospinning. To facilitate the electrospinning process poly(ethylene glycol) diacrylate (PEGDA) is combined with polyvinyl alcohol (PVA). PEGDA/PVA solutions can be successfully electrospun under constant UV light exposure to initiate the crosslinking of the PEGDA. Reactive electrospun fibers appear more stable immediately after spinning and after washing with water, indicating successful photo crosslinking.
format	article
author	Huling Jennifer Lyko Beate Illner Sabine Fiedler Nicklas Grabow Niels Teske Michael
author_facet	Huling Jennifer Lyko Beate Illner Sabine Fiedler Nicklas Grabow Niels Teske Michael
author_sort	Huling Jennifer
title	Development of UV-Reactive Electrospinning Method Based on Poly(ethylene glycol) diacrylate Crosslinking
title_short	Development of UV-Reactive Electrospinning Method Based on Poly(ethylene glycol) diacrylate Crosslinking
title_full	Development of UV-Reactive Electrospinning Method Based on Poly(ethylene glycol) diacrylate Crosslinking
title_fullStr	Development of UV-Reactive Electrospinning Method Based on Poly(ethylene glycol) diacrylate Crosslinking
title_full_unstemmed	Development of UV-Reactive Electrospinning Method Based on Poly(ethylene glycol) diacrylate Crosslinking
title_sort	development of uv-reactive electrospinning method based on poly(ethylene glycol) diacrylate crosslinking
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/02d3ef70920248408744db0828e7d3cf
work_keys_str_mv	AT hulingjennifer developmentofuvreactiveelectrospinningmethodbasedonpolyethyleneglycoldiacrylatecrosslinking AT lykobeate developmentofuvreactiveelectrospinningmethodbasedonpolyethyleneglycoldiacrylatecrosslinking AT illnersabine developmentofuvreactiveelectrospinningmethodbasedonpolyethyleneglycoldiacrylatecrosslinking AT fiedlernicklas developmentofuvreactiveelectrospinningmethodbasedonpolyethyleneglycoldiacrylatecrosslinking AT grabowniels developmentofuvreactiveelectrospinningmethodbasedonpolyethyleneglycoldiacrylatecrosslinking AT teskemichael developmentofuvreactiveelectrospinningmethodbasedonpolyethyleneglycoldiacrylatecrosslinking
_version_	1718371818712072192

Development of UV-Reactive Electrospinning Method Based on Poly(ethylene glycol) diacrylate Crosslinking

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