Characteristics of the lung microbiota in lower respiratory tract infections with and without history of pneumonia

Lung microbiota plays an important role in many diseases including lower respiratory tract infections (LRTI) and pneumonia. This study aimed to explore the effects of community-acquired pneumonia (CAP) on microbial diversity and identify potential biomarkers of respiratory tract in CAP LRTI patients...

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Autores principales:	Lingling Hong, Yuqing Chen, Ling Ye
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	lower respiratory tract infections history of pneumonia lung microbiota diagnosis Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/02d8f6b168794c7791747dbef60b819c
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spelling	oai:doaj.org-article:02d8f6b168794c7791747dbef60b819c2021-11-04T15:51:54ZCharacteristics of the lung microbiota in lower respiratory tract infections with and without history of pneumonia2165-59792165-598710.1080/21655979.2021.1997563https://doaj.org/article/02d8f6b168794c7791747dbef60b819c2021-10-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1997563https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Lung microbiota plays an important role in many diseases including lower respiratory tract infections (LRTI) and pneumonia. This study aimed to explore the effects of community-acquired pneumonia (CAP) on microbial diversity and identify potential biomarkers of respiratory tract in CAP LRTI patients. In the current study, a comprehensive bioinformatics analysis was performed based on metagenomic next generation sequencing technology, followed by alpha and beta diversity, LEfSe, and co-occurrence network analysis, and random forest model construction. Our results showed that CAP dramatically influenced taxon abundance, and the significant differences in microbiota including Proteobacteria, Bacteroidetes, Euryarchaeota, Firmicutes and Spirochaetes were observed at the phylum level. Co-occurrence network selected out novel modules involved in microbial proliferation-associated pathways. A random forest model screened Klebsiella pneumoniae and Bacillus cereus as potential diagnostic biomarkers with high AUC values. The microbial composition was different between CAP LRTI patients and non-CAP LRTI patients. Klebsiella pneumoniae and Bacillus cereus were strongly associated with increased severity of LRTI with a pneumonia history. Our findings provided an insight for a better understanding of community and structure of lung microbiota for future diagnosis and treatment in LRTI patients with a history of pneumonia. Moreover, these microbes were considered as potential biomarkers for predicting the risks for the treatment strategies of LRTI.Lingling HongYuqing ChenLing YeTaylor & Francis Grouparticlelower respiratory tract infectionshistory of pneumonialung microbiotadiagnosisBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lower respiratory tract infections history of pneumonia lung microbiota diagnosis Biotechnology TP248.13-248.65
spellingShingle	lower respiratory tract infections history of pneumonia lung microbiota diagnosis Biotechnology TP248.13-248.65 Lingling Hong Yuqing Chen Ling Ye Characteristics of the lung microbiota in lower respiratory tract infections with and without history of pneumonia
description	Lung microbiota plays an important role in many diseases including lower respiratory tract infections (LRTI) and pneumonia. This study aimed to explore the effects of community-acquired pneumonia (CAP) on microbial diversity and identify potential biomarkers of respiratory tract in CAP LRTI patients. In the current study, a comprehensive bioinformatics analysis was performed based on metagenomic next generation sequencing technology, followed by alpha and beta diversity, LEfSe, and co-occurrence network analysis, and random forest model construction. Our results showed that CAP dramatically influenced taxon abundance, and the significant differences in microbiota including Proteobacteria, Bacteroidetes, Euryarchaeota, Firmicutes and Spirochaetes were observed at the phylum level. Co-occurrence network selected out novel modules involved in microbial proliferation-associated pathways. A random forest model screened Klebsiella pneumoniae and Bacillus cereus as potential diagnostic biomarkers with high AUC values. The microbial composition was different between CAP LRTI patients and non-CAP LRTI patients. Klebsiella pneumoniae and Bacillus cereus were strongly associated with increased severity of LRTI with a pneumonia history. Our findings provided an insight for a better understanding of community and structure of lung microbiota for future diagnosis and treatment in LRTI patients with a history of pneumonia. Moreover, these microbes were considered as potential biomarkers for predicting the risks for the treatment strategies of LRTI.
format	article
author	Lingling Hong Yuqing Chen Ling Ye
author_facet	Lingling Hong Yuqing Chen Ling Ye
author_sort	Lingling Hong
title	Characteristics of the lung microbiota in lower respiratory tract infections with and without history of pneumonia
title_short	Characteristics of the lung microbiota in lower respiratory tract infections with and without history of pneumonia
title_full	Characteristics of the lung microbiota in lower respiratory tract infections with and without history of pneumonia
title_fullStr	Characteristics of the lung microbiota in lower respiratory tract infections with and without history of pneumonia
title_full_unstemmed	Characteristics of the lung microbiota in lower respiratory tract infections with and without history of pneumonia
title_sort	characteristics of the lung microbiota in lower respiratory tract infections with and without history of pneumonia
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/02d8f6b168794c7791747dbef60b819c
work_keys_str_mv	AT linglinghong characteristicsofthelungmicrobiotainlowerrespiratorytractinfectionswithandwithouthistoryofpneumonia AT yuqingchen characteristicsofthelungmicrobiotainlowerrespiratorytractinfectionswithandwithouthistoryofpneumonia AT lingye characteristicsofthelungmicrobiotainlowerrespiratorytractinfectionswithandwithouthistoryofpneumonia
_version_	1718444691530186752

Characteristics of the lung microbiota in lower respiratory tract infections with and without history of pneumonia

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