PRECONDITIONING AS PROTECTION AGAINST ISCHEMIC MYOCARDIAL INJURY

The article discusses the phenomenon of metabolic adaptation to ischemia after repeated episodes of transient reduction in myocardial perfusion. It is shown that the phenomenon of ischemic preconditioning is to significantly improve the stability of the ischemic tissue and reperfusion injury that oc...

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Autores principales:	M. G. Shurygin, I. A. Shurygina, N. N. Dremina, O. V. Kanya
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	fgf2 vegf ischemia preconditioning growth factors Science Q
Acceso en línea:	https://doaj.org/article/02d9cd88952849459764ca02804d56f8
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spelling	oai:doaj.org-article:02d9cd88952849459764ca02804d56f82021-11-23T06:14:26ZPRECONDITIONING AS PROTECTION AGAINST ISCHEMIC MYOCARDIAL INJURY2541-94202587-9596https://doaj.org/article/02d9cd88952849459764ca02804d56f82013-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1476https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The article discusses the phenomenon of metabolic adaptation to ischemia after repeated episodes of transient reduction in myocardial perfusion. It is shown that the phenomenon of ischemic preconditioning is to significantly improve the stability of the ischemic tissue and reperfusion injury that occurs after a few brief episodes of ischemia-reperfusion. Thus ischemic preconditioning is a multifactorial phenomenon, as implemented through adaptation to changes in the intracellular cascade of metabolic conditions and the restructuring of the myocardium with increased tolerance to its lower perfusion. The use of external actions aimed at the individual links of the process or set of them, will improve the outcomes of ischemic episodes, and better preservation of myocardial function in a compromised vascular bed. It is shown that one of the major incentives of ischemic preconditioning may make growth factors - FGF2 and VEGF. In this case, the protective effect is realized as by increasing the viability of myocardial contractile cells and vascular endothelial cells in myocardial ischemic damage of the hearth, and by neo-angiogenesis and improve the regenerative ability of mature cardiomyocytes.M. G. ShuryginI. A. ShuryginaN. N. DreminaO. V. KanyaScientific Сentre for Family Health and Human Reproduction Problemsarticlefgf2vegfischemia preconditioninggrowth factorsfgf2vegfScienceQRUActa Biomedica Scientifica, Vol 0, Iss 2(2), Pp 206-210 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	fgf2 vegf ischemia preconditioning growth factors fgf2 vegf Science Q
spellingShingle	fgf2 vegf ischemia preconditioning growth factors fgf2 vegf Science Q M. G. Shurygin I. A. Shurygina N. N. Dremina O. V. Kanya PRECONDITIONING AS PROTECTION AGAINST ISCHEMIC MYOCARDIAL INJURY
description	The article discusses the phenomenon of metabolic adaptation to ischemia after repeated episodes of transient reduction in myocardial perfusion. It is shown that the phenomenon of ischemic preconditioning is to significantly improve the stability of the ischemic tissue and reperfusion injury that occurs after a few brief episodes of ischemia-reperfusion. Thus ischemic preconditioning is a multifactorial phenomenon, as implemented through adaptation to changes in the intracellular cascade of metabolic conditions and the restructuring of the myocardium with increased tolerance to its lower perfusion. The use of external actions aimed at the individual links of the process or set of them, will improve the outcomes of ischemic episodes, and better preservation of myocardial function in a compromised vascular bed. It is shown that one of the major incentives of ischemic preconditioning may make growth factors - FGF2 and VEGF. In this case, the protective effect is realized as by increasing the viability of myocardial contractile cells and vascular endothelial cells in myocardial ischemic damage of the hearth, and by neo-angiogenesis and improve the regenerative ability of mature cardiomyocytes.
format	article
author	M. G. Shurygin I. A. Shurygina N. N. Dremina O. V. Kanya
author_facet	M. G. Shurygin I. A. Shurygina N. N. Dremina O. V. Kanya
author_sort	M. G. Shurygin
title	PRECONDITIONING AS PROTECTION AGAINST ISCHEMIC MYOCARDIAL INJURY
title_short	PRECONDITIONING AS PROTECTION AGAINST ISCHEMIC MYOCARDIAL INJURY
title_full	PRECONDITIONING AS PROTECTION AGAINST ISCHEMIC MYOCARDIAL INJURY
title_fullStr	PRECONDITIONING AS PROTECTION AGAINST ISCHEMIC MYOCARDIAL INJURY
title_full_unstemmed	PRECONDITIONING AS PROTECTION AGAINST ISCHEMIC MYOCARDIAL INJURY
title_sort	preconditioning as protection against ischemic myocardial injury
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/02d9cd88952849459764ca02804d56f8
work_keys_str_mv	AT mgshurygin preconditioningasprotectionagainstischemicmyocardialinjury AT iashurygina preconditioningasprotectionagainstischemicmyocardialinjury AT nndremina preconditioningasprotectionagainstischemicmyocardialinjury AT ovkanya preconditioningasprotectionagainstischemicmyocardialinjury
_version_	1718417174093103104

PRECONDITIONING AS PROTECTION AGAINST ISCHEMIC MYOCARDIAL INJURY

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