Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride

Human steroid 5α-reductase 2 (SRD5A2) is an integral membrane enzyme and catalyzes 5α-reduction of testosterone to dihydrotestosterone. Structural analysis accompanied by computational and mutagenesis studies reveal the mechanisms of catalysis and inhibition by clinically relevant drugs targeting SR...

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Main Authors:	Qingpin Xiao, Lei Wang, Shreyas Supekar, Tao Shen, Heng Liu, Fei Ye, Junzhou Huang, Hao Fan, Zhiyi Wei, Cheng Zhang
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/02da957885df4ecebfa4e69a4ccee43b
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spelling	oai:doaj.org-article:02da957885df4ecebfa4e69a4ccee43b2021-12-02T16:56:32ZStructure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride10.1038/s41467-020-19249-z2041-1723https://doaj.org/article/02da957885df4ecebfa4e69a4ccee43b2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19249-zhttps://doaj.org/toc/2041-1723Human steroid 5α-reductase 2 (SRD5A2) is an integral membrane enzyme and catalyzes 5α-reduction of testosterone to dihydrotestosterone. Structural analysis accompanied by computational and mutagenesis studies reveal the mechanisms of catalysis and inhibition by clinically relevant drugs targeting SRD5A2.Qingpin XiaoLei WangShreyas SupekarTao ShenHeng LiuFei YeJunzhou HuangHao FanZhiyi WeiCheng ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qingpin Xiao Lei Wang Shreyas Supekar Tao Shen Heng Liu Fei Ye Junzhou Huang Hao Fan Zhiyi Wei Cheng Zhang Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
description	Human steroid 5α-reductase 2 (SRD5A2) is an integral membrane enzyme and catalyzes 5α-reduction of testosterone to dihydrotestosterone. Structural analysis accompanied by computational and mutagenesis studies reveal the mechanisms of catalysis and inhibition by clinically relevant drugs targeting SRD5A2.
format	article
author	Qingpin Xiao Lei Wang Shreyas Supekar Tao Shen Heng Liu Fei Ye Junzhou Huang Hao Fan Zhiyi Wei Cheng Zhang
author_facet	Qingpin Xiao Lei Wang Shreyas Supekar Tao Shen Heng Liu Fei Ye Junzhou Huang Hao Fan Zhiyi Wei Cheng Zhang
author_sort	Qingpin Xiao
title	Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
title_short	Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
title_full	Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
title_fullStr	Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
title_full_unstemmed	Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
title_sort	structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/02da957885df4ecebfa4e69a4ccee43b
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Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride

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