Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride

Human steroid 5α-reductase 2 (SRD5A2) is an integral membrane enzyme and catalyzes 5α-reduction of testosterone to dihydrotestosterone. Structural analysis accompanied by computational and mutagenesis studies reveal the mechanisms of catalysis and inhibition by clinically relevant drugs targeting SR...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qingpin Xiao, Lei Wang, Shreyas Supekar, Tao Shen, Heng Liu, Fei Ye, Junzhou Huang, Hao Fan, Zhiyi Wei, Cheng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/02da957885df4ecebfa4e69a4ccee43b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:02da957885df4ecebfa4e69a4ccee43b
record_format	dspace
spelling	oai:doaj.org-article:02da957885df4ecebfa4e69a4ccee43b2021-12-02T16:56:32ZStructure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride10.1038/s41467-020-19249-z2041-1723https://doaj.org/article/02da957885df4ecebfa4e69a4ccee43b2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19249-zhttps://doaj.org/toc/2041-1723Human steroid 5α-reductase 2 (SRD5A2) is an integral membrane enzyme and catalyzes 5α-reduction of testosterone to dihydrotestosterone. Structural analysis accompanied by computational and mutagenesis studies reveal the mechanisms of catalysis and inhibition by clinically relevant drugs targeting SRD5A2.Qingpin XiaoLei WangShreyas SupekarTao ShenHeng LiuFei YeJunzhou HuangHao FanZhiyi WeiCheng ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qingpin Xiao Lei Wang Shreyas Supekar Tao Shen Heng Liu Fei Ye Junzhou Huang Hao Fan Zhiyi Wei Cheng Zhang Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
description	Human steroid 5α-reductase 2 (SRD5A2) is an integral membrane enzyme and catalyzes 5α-reduction of testosterone to dihydrotestosterone. Structural analysis accompanied by computational and mutagenesis studies reveal the mechanisms of catalysis and inhibition by clinically relevant drugs targeting SRD5A2.
format	article
author	Qingpin Xiao Lei Wang Shreyas Supekar Tao Shen Heng Liu Fei Ye Junzhou Huang Hao Fan Zhiyi Wei Cheng Zhang
author_facet	Qingpin Xiao Lei Wang Shreyas Supekar Tao Shen Heng Liu Fei Ye Junzhou Huang Hao Fan Zhiyi Wei Cheng Zhang
author_sort	Qingpin Xiao
title	Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
title_short	Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
title_full	Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
title_fullStr	Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
title_full_unstemmed	Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
title_sort	structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/02da957885df4ecebfa4e69a4ccee43b
work_keys_str_mv	AT qingpinxiao structureofhumansteroid5areductase2withtheantiandrogendrugfinasteride AT leiwang structureofhumansteroid5areductase2withtheantiandrogendrugfinasteride AT shreyassupekar structureofhumansteroid5areductase2withtheantiandrogendrugfinasteride AT taoshen structureofhumansteroid5areductase2withtheantiandrogendrugfinasteride AT hengliu structureofhumansteroid5areductase2withtheantiandrogendrugfinasteride AT feiye structureofhumansteroid5areductase2withtheantiandrogendrugfinasteride AT junzhouhuang structureofhumansteroid5areductase2withtheantiandrogendrugfinasteride AT haofan structureofhumansteroid5areductase2withtheantiandrogendrugfinasteride AT zhiyiwei structureofhumansteroid5areductase2withtheantiandrogendrugfinasteride AT chengzhang structureofhumansteroid5areductase2withtheantiandrogendrugfinasteride
_version_	1718382779544109056

Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride

Ejemplares similares