Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility

Barbora Dobiasova, Michal Mego 2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Bratislava, Slovak RepublicCorrespondence: Michal Mego 2 nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Klenova 1, Bratisl...

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Autores principales: Dobiasova B, Mego M
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Publicado: Dove Medical Press 2020
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spelling oai:doaj.org-article:02dcb47d941a4a6a9f0c1b0d187f4a582021-12-02T08:01:07ZBiomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility1179-1314https://doaj.org/article/02dcb47d941a4a6a9f0c1b0d187f4a582020-10-01T00:00:00Zhttps://www.dovepress.com/biomarkers-for-inflammatory-breast-cancer-diagnostic-and-therapeutic-u-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Barbora Dobiasova, Michal Mego 2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Bratislava, Slovak RepublicCorrespondence: Michal Mego 2 nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Klenova 1, Bratislava 833 10, Slovak RepublicTel +421-2-59378366Fax +421-2-54774943Email misomego@gmail.comAbstract: Inflammatory breast cancer (IBC) is a rare and highly aggressive subtype of advanced breast cancer. The aggressive behavior, resistance to chemotherapy, angiogenesis, and high metastatic potential are key intrinsic characteristics of IBC caused by many specific factors. Pathogenesis and behavior of IBC are closely related to tumor surrounding inflammatory and immune cells, blood vessels, and extracellular matrix, which are all components of the tumor microenvironment (TME). The tumor microenvironment has a crucial role in the local immune r09esponse. The communication between intrinsic and extrinsic components of IBC and the abundance of cytokines and chemokines in the TME strongly contribute to the aggressiveness and high angiogenic potential of this tumor. Critical modes of interaction are cytokine-mediated communication and direct intercellular contact between cancer cells and tumor microenvironment with a variety of pathway crosstalk. This review aimed to summarize current knowledge of predictive and prognostic biomarkers in IBC.Keywords: inflammatory breast neoplasms, biomarkers, tumor microenvironment, targeted therapyDobiasova BMego MDove Medical Pressarticleinflammatory breast neoplasmsbiomarkerstumor microenvironmenttargeted therapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 12, Pp 153-163 (2020)
institution DOAJ
collection DOAJ
language EN
topic inflammatory breast neoplasms
biomarkers
tumor microenvironment
targeted therapy
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle inflammatory breast neoplasms
biomarkers
tumor microenvironment
targeted therapy
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Dobiasova B
Mego M
Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility
description Barbora Dobiasova, Michal Mego 2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Bratislava, Slovak RepublicCorrespondence: Michal Mego 2 nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Klenova 1, Bratislava 833 10, Slovak RepublicTel +421-2-59378366Fax +421-2-54774943Email misomego@gmail.comAbstract: Inflammatory breast cancer (IBC) is a rare and highly aggressive subtype of advanced breast cancer. The aggressive behavior, resistance to chemotherapy, angiogenesis, and high metastatic potential are key intrinsic characteristics of IBC caused by many specific factors. Pathogenesis and behavior of IBC are closely related to tumor surrounding inflammatory and immune cells, blood vessels, and extracellular matrix, which are all components of the tumor microenvironment (TME). The tumor microenvironment has a crucial role in the local immune r09esponse. The communication between intrinsic and extrinsic components of IBC and the abundance of cytokines and chemokines in the TME strongly contribute to the aggressiveness and high angiogenic potential of this tumor. Critical modes of interaction are cytokine-mediated communication and direct intercellular contact between cancer cells and tumor microenvironment with a variety of pathway crosstalk. This review aimed to summarize current knowledge of predictive and prognostic biomarkers in IBC.Keywords: inflammatory breast neoplasms, biomarkers, tumor microenvironment, targeted therapy
format article
author Dobiasova B
Mego M
author_facet Dobiasova B
Mego M
author_sort Dobiasova B
title Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility
title_short Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility
title_full Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility
title_fullStr Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility
title_full_unstemmed Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility
title_sort biomarkers for inflammatory breast cancer: diagnostic and therapeutic utility
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/02dcb47d941a4a6a9f0c1b0d187f4a58
work_keys_str_mv AT dobiasovab biomarkersforinflammatorybreastcancerdiagnosticandtherapeuticutility
AT megom biomarkersforinflammatorybreastcancerdiagnosticandtherapeuticutility
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