Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility

Barbora Dobiasova, Michal Mego 2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Bratislava, Slovak RepublicCorrespondence: Michal Mego 2 nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Klenova 1, Bratisl...

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Autores principales:	Dobiasova B, Mego M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	inflammatory breast neoplasms biomarkers tumor microenvironment targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/02dcb47d941a4a6a9f0c1b0d187f4a58
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spelling	oai:doaj.org-article:02dcb47d941a4a6a9f0c1b0d187f4a582021-12-02T08:01:07ZBiomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility1179-1314https://doaj.org/article/02dcb47d941a4a6a9f0c1b0d187f4a582020-10-01T00:00:00Zhttps://www.dovepress.com/biomarkers-for-inflammatory-breast-cancer-diagnostic-and-therapeutic-u-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Barbora Dobiasova, Michal Mego 2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Bratislava, Slovak RepublicCorrespondence: Michal Mego 2 nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Klenova 1, Bratislava 833 10, Slovak RepublicTel +421-2-59378366Fax +421-2-54774943Email misomego@gmail.comAbstract: Inflammatory breast cancer (IBC) is a rare and highly aggressive subtype of advanced breast cancer. The aggressive behavior, resistance to chemotherapy, angiogenesis, and high metastatic potential are key intrinsic characteristics of IBC caused by many specific factors. Pathogenesis and behavior of IBC are closely related to tumor surrounding inflammatory and immune cells, blood vessels, and extracellular matrix, which are all components of the tumor microenvironment (TME). The tumor microenvironment has a crucial role in the local immune r09esponse. The communication between intrinsic and extrinsic components of IBC and the abundance of cytokines and chemokines in the TME strongly contribute to the aggressiveness and high angiogenic potential of this tumor. Critical modes of interaction are cytokine-mediated communication and direct intercellular contact between cancer cells and tumor microenvironment with a variety of pathway crosstalk. This review aimed to summarize current knowledge of predictive and prognostic biomarkers in IBC.Keywords: inflammatory breast neoplasms, biomarkers, tumor microenvironment, targeted therapyDobiasova BMego MDove Medical Pressarticleinflammatory breast neoplasmsbiomarkerstumor microenvironmenttargeted therapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 12, Pp 153-163 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammatory breast neoplasms biomarkers tumor microenvironment targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	inflammatory breast neoplasms biomarkers tumor microenvironment targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Dobiasova B Mego M Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility
description	Barbora Dobiasova, Michal Mego 2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Bratislava, Slovak RepublicCorrespondence: Michal Mego 2 nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Klenova 1, Bratislava 833 10, Slovak RepublicTel +421-2-59378366Fax +421-2-54774943Email misomego@gmail.comAbstract: Inflammatory breast cancer (IBC) is a rare and highly aggressive subtype of advanced breast cancer. The aggressive behavior, resistance to chemotherapy, angiogenesis, and high metastatic potential are key intrinsic characteristics of IBC caused by many specific factors. Pathogenesis and behavior of IBC are closely related to tumor surrounding inflammatory and immune cells, blood vessels, and extracellular matrix, which are all components of the tumor microenvironment (TME). The tumor microenvironment has a crucial role in the local immune r09esponse. The communication between intrinsic and extrinsic components of IBC and the abundance of cytokines and chemokines in the TME strongly contribute to the aggressiveness and high angiogenic potential of this tumor. Critical modes of interaction are cytokine-mediated communication and direct intercellular contact between cancer cells and tumor microenvironment with a variety of pathway crosstalk. This review aimed to summarize current knowledge of predictive and prognostic biomarkers in IBC.Keywords: inflammatory breast neoplasms, biomarkers, tumor microenvironment, targeted therapy
format	article
author	Dobiasova B Mego M
author_facet	Dobiasova B Mego M
author_sort	Dobiasova B
title	Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility
title_short	Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility
title_full	Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility
title_fullStr	Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility
title_full_unstemmed	Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility
title_sort	biomarkers for inflammatory breast cancer: diagnostic and therapeutic utility
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/02dcb47d941a4a6a9f0c1b0d187f4a58
work_keys_str_mv	AT dobiasovab biomarkersforinflammatorybreastcancerdiagnosticandtherapeuticutility AT megom biomarkersforinflammatorybreastcancerdiagnosticandtherapeuticutility
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Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility

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