FORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT

ABSTRACT Poly (D,L-lactide acid) has been used as scaffold for tissue engineering. In this study, PDLLA microparticles were made into porous microparticles. Porous microparticles were proposed to reduce burst release of protein and to prevent diffusion of released protein into non-target tissue. F...

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Autores principales:	Lili Fitriani, Tri Suciati
Formato:	article
Lenguaje:	EN ID
Publicado:	Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas 2015
Materias:	Chemistry QD1-999 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/02e0e9d291564e249ff8af480a2ea76a
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spelling	oai:doaj.org-article:02e0e9d291564e249ff8af480a2ea76a2021-12-02T10:57:45ZFORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT1978-628X2476-896010.25077/jrk.v4i2.120https://doaj.org/article/02e0e9d291564e249ff8af480a2ea76a2015-02-01T00:00:00Zhttp://jrk.fmipa.unand.ac.id/index.php/jrk/article/view/120https://doaj.org/toc/1978-628Xhttps://doaj.org/toc/2476-8960ABSTRACT Poly (D,L-lactide acid) has been used as scaffold for tissue engineering. In this study, PDLLA microparticles were made into porous microparticles. Porous microparticles were proposed to reduce burst release of protein and to prevent diffusion of released protein into non-target tissue. Formulation of porous microparticles was made by water-oil-water (W1/O/W2) emulsification-solvent evaporation using gas foamed as porogen. Variations of the amount of sodium bicarbonate, volume of citric acid solution and time for homogenization were optimized to produce optimum formulation. Evaluation for this microparticles included morphology of particles, particle size distribution and porosity. Porous microparticle produced by ratio volume of acid : dichloromethane : poly(vynil alcohol) (PVA) = 1:3:3 and the ratio of sodium bicarbonate : PDLLA = 2:3 was the optimum formulation. Keywords :Porous Microparticles, PDLLA,Gas Foamed, Scaffold, Solvent EvaporationLili FitrianiTri SuciatiDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas AndalasarticleChemistryQD1-999BiochemistryQD415-436ENIDJurnal Riset Kimia, Vol 4, Iss 2 (2015)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	Chemistry QD1-999 Biochemistry QD415-436
spellingShingle	Chemistry QD1-999 Biochemistry QD415-436 Lili Fitriani Tri Suciati FORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT
description	ABSTRACT Poly (D,L-lactide acid) has been used as scaffold for tissue engineering. In this study, PDLLA microparticles were made into porous microparticles. Porous microparticles were proposed to reduce burst release of protein and to prevent diffusion of released protein into non-target tissue. Formulation of porous microparticles was made by water-oil-water (W1/O/W2) emulsification-solvent evaporation using gas foamed as porogen. Variations of the amount of sodium bicarbonate, volume of citric acid solution and time for homogenization were optimized to produce optimum formulation. Evaluation for this microparticles included morphology of particles, particle size distribution and porosity. Porous microparticle produced by ratio volume of acid : dichloromethane : poly(vynil alcohol) (PVA) = 1:3:3 and the ratio of sodium bicarbonate : PDLLA = 2:3 was the optimum formulation. Keywords :Porous Microparticles, PDLLA,Gas Foamed, Scaffold, Solvent Evaporation
format	article
author	Lili Fitriani Tri Suciati
author_facet	Lili Fitriani Tri Suciati
author_sort	Lili Fitriani
title	FORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT
title_short	FORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT
title_full	FORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT
title_fullStr	FORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT
title_full_unstemmed	FORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT
title_sort	formulasi mikropartikel berpori dalam poli (d,l-laktida) sebagai scaffolddengan teknik emulsifikasi penguapan pelarut
publisher	Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas
publishDate	2015
url	https://doaj.org/article/02e0e9d291564e249ff8af480a2ea76a
work_keys_str_mv	AT lilifitriani formulasimikropartikelberporidalampolidllaktidasebagaiscaffolddenganteknikemulsifikasipenguapanpelarut AT trisuciati formulasimikropartikelberporidalampolidllaktidasebagaiscaffolddenganteknikemulsifikasipenguapanpelarut
_version_	1718396391161593856

FORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT

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