The role of endothelial damage and dyslipidemia in the development of cardiovascular pathology in psoriatic arthritis

An increased risk of cardiovascular events has now been identified in patients with psoriatic arthritis. The chronic immune-mediated inflammation underlying psoriatic arthritis (PA) leads to the development of dyslipidemia, atherosclerosis and its complications, in particular, a high risk of cardiov...

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Autores principales:	Zarema R. Khismatullina, Ksenia M. Koreshkova
Formato:	article
Lenguaje:	RU
Publicado:	State Scientific Center of Dermatovenereology and Cosmetology 2021
Materias:	psoriatic arthritis dyslipidemias atherosclerosis cardiovascular complications Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/02e308f43c6744709c9428eeb4e7f89a
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spelling	oai:doaj.org-article:02e308f43c6744709c9428eeb4e7f89a2021-12-01T22:16:30ZThe role of endothelial damage and dyslipidemia in the development of cardiovascular pathology in psoriatic arthritis0042-46092313-629410.25208/vdv1206https://doaj.org/article/02e308f43c6744709c9428eeb4e7f89a2021-04-01T00:00:00Zhttps://vestnikdv.ru/jour/article/viewFile/1206/1179https://doaj.org/toc/0042-4609https://doaj.org/toc/2313-6294An increased risk of cardiovascular events has now been identified in patients with psoriatic arthritis. The chronic immune-mediated inflammation underlying psoriatic arthritis (PA) leads to the development of dyslipidemia, atherosclerosis and its complications, in particular, a high risk of cardiovascular complications. For PA, dyslipidemias are most characteristic, manifested by an increased level of low and very low density lipoproteins, triglycerides and total cholesterol, which correlates with the activity of the disease. The literature review studied the pathogenesis of dyslipidemias and vascular wall lesions in psoriatic arthritis, analyzed the literature on cardiovascular complications and mortality among patients with PA, studied the issues of total cardiovascular risk, presented the results of numerous clinical studies that allow PA to be considered a disease associated with increased the risk of cardiovascular complications. Considering the role of proinflammatory cytokines in the pathogenesis of psoriatic arthritis, early detection of endothelial lesions represents the most promising direction in the prevention of cardiovascular diseases, which are the main cause of mortality in this group of patients.Zarema R. KhismatullinaKsenia M. KoreshkovaState Scientific Center of Dermatovenereology and Cosmetologyarticlepsoriatic arthritisdyslipidemiasatherosclerosiscardiovascular complicationsDermatologyRL1-803RUVestnik Dermatologii i Venerologii, Vol 97, Iss 2, Pp 16-22 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	psoriatic arthritis dyslipidemias atherosclerosis cardiovascular complications Dermatology RL1-803
spellingShingle	psoriatic arthritis dyslipidemias atherosclerosis cardiovascular complications Dermatology RL1-803 Zarema R. Khismatullina Ksenia M. Koreshkova The role of endothelial damage and dyslipidemia in the development of cardiovascular pathology in psoriatic arthritis
description	An increased risk of cardiovascular events has now been identified in patients with psoriatic arthritis. The chronic immune-mediated inflammation underlying psoriatic arthritis (PA) leads to the development of dyslipidemia, atherosclerosis and its complications, in particular, a high risk of cardiovascular complications. For PA, dyslipidemias are most characteristic, manifested by an increased level of low and very low density lipoproteins, triglycerides and total cholesterol, which correlates with the activity of the disease. The literature review studied the pathogenesis of dyslipidemias and vascular wall lesions in psoriatic arthritis, analyzed the literature on cardiovascular complications and mortality among patients with PA, studied the issues of total cardiovascular risk, presented the results of numerous clinical studies that allow PA to be considered a disease associated with increased the risk of cardiovascular complications. Considering the role of proinflammatory cytokines in the pathogenesis of psoriatic arthritis, early detection of endothelial lesions represents the most promising direction in the prevention of cardiovascular diseases, which are the main cause of mortality in this group of patients.
format	article
author	Zarema R. Khismatullina Ksenia M. Koreshkova
author_facet	Zarema R. Khismatullina Ksenia M. Koreshkova
author_sort	Zarema R. Khismatullina
title	The role of endothelial damage and dyslipidemia in the development of cardiovascular pathology in psoriatic arthritis
title_short	The role of endothelial damage and dyslipidemia in the development of cardiovascular pathology in psoriatic arthritis
title_full	The role of endothelial damage and dyslipidemia in the development of cardiovascular pathology in psoriatic arthritis
title_fullStr	The role of endothelial damage and dyslipidemia in the development of cardiovascular pathology in psoriatic arthritis
title_full_unstemmed	The role of endothelial damage and dyslipidemia in the development of cardiovascular pathology in psoriatic arthritis
title_sort	role of endothelial damage and dyslipidemia in the development of cardiovascular pathology in psoriatic arthritis
publisher	State Scientific Center of Dermatovenereology and Cosmetology
publishDate	2021
url	https://doaj.org/article/02e308f43c6744709c9428eeb4e7f89a
work_keys_str_mv	AT zaremarkhismatullina theroleofendothelialdamageanddyslipidemiainthedevelopmentofcardiovascularpathologyinpsoriaticarthritis AT kseniamkoreshkova theroleofendothelialdamageanddyslipidemiainthedevelopmentofcardiovascularpathologyinpsoriaticarthritis AT zaremarkhismatullina roleofendothelialdamageanddyslipidemiainthedevelopmentofcardiovascularpathologyinpsoriaticarthritis AT kseniamkoreshkova roleofendothelialdamageanddyslipidemiainthedevelopmentofcardiovascularpathologyinpsoriaticarthritis
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The role of endothelial damage and dyslipidemia in the development of cardiovascular pathology in psoriatic arthritis

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