Stereotactic radiotherapy for wet age-related macular degeneration: current perspectives

James E Neffendorf, Timothy L Jackson Department of Ophthalmology, School of Medicine, King’s College London, London, United Kingdom Abstract: Neovascular age-related macular degeneration is a leading cause of blindness in the developed world. Currently, the treatment of choice is intrav...

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Autores principales:	Neffendorf JE, Jackson TL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/02e5ba0f0a98414db52aa02139552559
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spelling	oai:doaj.org-article:02e5ba0f0a98414db52aa021395525592021-12-02T00:35:24ZStereotactic radiotherapy for wet age-related macular degeneration: current perspectives1177-5483https://doaj.org/article/02e5ba0f0a98414db52aa021395525592015-09-01T00:00:00Zhttps://www.dovepress.com/stereotactic-radiotherapy-for-wet-age-related-macular-degeneration-cur-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483James E Neffendorf, Timothy L Jackson Department of Ophthalmology, School of Medicine, King’s College London, London, United Kingdom Abstract: Neovascular age-related macular degeneration is a leading cause of blindness in the developed world. Currently, the treatment of choice is intravitreal injections of anti-VEGF medications. These require frequent dosing, up to monthly, and impose a substantial burden on patients and the health economy. Ionizing radiation was proposed as a possible treatment for age-related macular degeneration due to its anti-inflammatory and anti-fibrotic properties. Stereotactic radiotherapy is an outpatient-based radiotherapy platform that provides stereotactic application of low energy X-ray to the retina in three highly collimated beams that cross the inferior sclera to overlap at the macula. A randomized, double-masked, sham-controlled trial of 230 patients (INTREPID) showed that a single dose of stereotactic radiotherapy significantly reduces the number of intravitreal anti-VEGF injections needed over 2 years. A larger randomized controlled trial (STAR) is underway. Keywords: wet age-related macular degeneration, radiation therapy, stereotactic radiotherapy, vascular endothelial growth factorNeffendorf JEJackson TLDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 1829-1834 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Neffendorf JE Jackson TL Stereotactic radiotherapy for wet age-related macular degeneration: current perspectives
description	James E Neffendorf, Timothy L Jackson Department of Ophthalmology, School of Medicine, King’s College London, London, United Kingdom Abstract: Neovascular age-related macular degeneration is a leading cause of blindness in the developed world. Currently, the treatment of choice is intravitreal injections of anti-VEGF medications. These require frequent dosing, up to monthly, and impose a substantial burden on patients and the health economy. Ionizing radiation was proposed as a possible treatment for age-related macular degeneration due to its anti-inflammatory and anti-fibrotic properties. Stereotactic radiotherapy is an outpatient-based radiotherapy platform that provides stereotactic application of low energy X-ray to the retina in three highly collimated beams that cross the inferior sclera to overlap at the macula. A randomized, double-masked, sham-controlled trial of 230 patients (INTREPID) showed that a single dose of stereotactic radiotherapy significantly reduces the number of intravitreal anti-VEGF injections needed over 2 years. A larger randomized controlled trial (STAR) is underway. Keywords: wet age-related macular degeneration, radiation therapy, stereotactic radiotherapy, vascular endothelial growth factor
format	article
author	Neffendorf JE Jackson TL
author_facet	Neffendorf JE Jackson TL
author_sort	Neffendorf JE
title	Stereotactic radiotherapy for wet age-related macular degeneration: current perspectives
title_short	Stereotactic radiotherapy for wet age-related macular degeneration: current perspectives
title_full	Stereotactic radiotherapy for wet age-related macular degeneration: current perspectives
title_fullStr	Stereotactic radiotherapy for wet age-related macular degeneration: current perspectives
title_full_unstemmed	Stereotactic radiotherapy for wet age-related macular degeneration: current perspectives
title_sort	stereotactic radiotherapy for wet age-related macular degeneration: current perspectives
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/02e5ba0f0a98414db52aa02139552559
work_keys_str_mv	AT neffendorfje stereotacticradiotherapyforwetagerelatedmaculardegenerationcurrentperspectives AT jacksontl stereotacticradiotherapyforwetagerelatedmaculardegenerationcurrentperspectives
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Stereotactic radiotherapy for wet age-related macular degeneration: current perspectives

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