The response to Hepatitis B virus vaccine in HIV-infected patients (HIV/AIDS counseling and care center in Kermanshah)

Background and Objective: HBV infection is preventable by effective vaccination in general population, but response to vaccine among HIV infected people seems to be low. Methods: In this prospective study, 48 HIV position patients with anti HBs-Ab and HBs Ag had hepatitis B vaccination (0, 1, 6 mont...

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Autores principales:	K Alaei, SD Mansoori, A Alaei
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2004
Materias:	hiv/aids hepatitis b vaccine cd<sub>4</sub>+ t lymphocytes Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/02e94a464d464fcd9eefe339cb8deeba
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spelling	oai:doaj.org-article:02e94a464d464fcd9eefe339cb8deeba2021-11-10T09:16:04ZThe response to Hepatitis B virus vaccine in HIV-infected patients (HIV/AIDS counseling and care center in Kermanshah)1561-41072251-7170https://doaj.org/article/02e94a464d464fcd9eefe339cb8deeba2004-04-01T00:00:00Zhttp://jbums.org/article-1-2713-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: HBV infection is preventable by effective vaccination in general population, but response to vaccine among HIV infected people seems to be low. Methods: In this prospective study, 48 HIV position patients with anti HBs-Ab and HBs Ag had hepatitis B vaccination (0, 1, 6 months). Anti-HBs levels were measured two months after the last dose by ELISA method. Cellular immunity was evaluated by flowcytometry. Findings: Only 14 (29.1%) of vaccinated HIV-infected patients had positive anti-HBs titers (11 males, 3 females). Among them, 4 (28.6%) were over 40 years and from 34 HIV positive patients who did not respond to hepatitis B vaccine, 10 (29.4%) were over 40 years old. The mean number of CD4+ T lymphocytes was 352.5 in responders and 283.9 in non-responders. 2 (17.6%) of 17 HIV positive patients with CD4+ T <200 AND 6 (31.5%) of 19 HIV positive patients with 200<CD4<500 and 3 (42.8%) of 7 HIV positive with CD4>500 responded to hepatitis B vaccine. Conclusion: Hepatitis B vaccination is better to be administered at the early stage of HIV infection. Conventional dose HIV vaccine is not enough for immunity. Therefore, it is recommended two-fold dose and repeated conventional dose or increasing interval administration of hepatitis B vaccine.K AlaeiSD MansooriA AlaeiBabol University of Medical Sciencesarticlehiv/aidshepatitis b vaccinecd<sub>4</sub>+ t lymphocytesMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 6, Iss 2, Pp 46-51 (2004)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	hiv/aids hepatitis b vaccine cd<sub>4</sub>+ t lymphocytes Medicine R Medicine (General) R5-920
spellingShingle	hiv/aids hepatitis b vaccine cd<sub>4</sub>+ t lymphocytes Medicine R Medicine (General) R5-920 K Alaei SD Mansoori A Alaei The response to Hepatitis B virus vaccine in HIV-infected patients (HIV/AIDS counseling and care center in Kermanshah)
description	Background and Objective: HBV infection is preventable by effective vaccination in general population, but response to vaccine among HIV infected people seems to be low. Methods: In this prospective study, 48 HIV position patients with anti HBs-Ab and HBs Ag had hepatitis B vaccination (0, 1, 6 months). Anti-HBs levels were measured two months after the last dose by ELISA method. Cellular immunity was evaluated by flowcytometry. Findings: Only 14 (29.1%) of vaccinated HIV-infected patients had positive anti-HBs titers (11 males, 3 females). Among them, 4 (28.6%) were over 40 years and from 34 HIV positive patients who did not respond to hepatitis B vaccine, 10 (29.4%) were over 40 years old. The mean number of CD4+ T lymphocytes was 352.5 in responders and 283.9 in non-responders. 2 (17.6%) of 17 HIV positive patients with CD4+ T <200 AND 6 (31.5%) of 19 HIV positive patients with 200<CD4<500 and 3 (42.8%) of 7 HIV positive with CD4>500 responded to hepatitis B vaccine. Conclusion: Hepatitis B vaccination is better to be administered at the early stage of HIV infection. Conventional dose HIV vaccine is not enough for immunity. Therefore, it is recommended two-fold dose and repeated conventional dose or increasing interval administration of hepatitis B vaccine.
format	article
author	K Alaei SD Mansoori A Alaei
author_facet	K Alaei SD Mansoori A Alaei
author_sort	K Alaei
title	The response to Hepatitis B virus vaccine in HIV-infected patients (HIV/AIDS counseling and care center in Kermanshah)
title_short	The response to Hepatitis B virus vaccine in HIV-infected patients (HIV/AIDS counseling and care center in Kermanshah)
title_full	The response to Hepatitis B virus vaccine in HIV-infected patients (HIV/AIDS counseling and care center in Kermanshah)
title_fullStr	The response to Hepatitis B virus vaccine in HIV-infected patients (HIV/AIDS counseling and care center in Kermanshah)
title_full_unstemmed	The response to Hepatitis B virus vaccine in HIV-infected patients (HIV/AIDS counseling and care center in Kermanshah)
title_sort	response to hepatitis b virus vaccine in hiv-infected patients (hiv/aids counseling and care center in kermanshah)
publisher	Babol University of Medical Sciences
publishDate	2004
url	https://doaj.org/article/02e94a464d464fcd9eefe339cb8deeba
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The response to Hepatitis B virus vaccine in HIV-infected patients (HIV/AIDS counseling and care center in Kermanshah)

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