Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis

Sparking immunity: Bioelectric signaling modulates immunity and regeneration Bioelectrical signaling in the African clawed frog modulates both resistance to infection and tail regeneration. Michael Levin at Tufts University in Massachusetts, USA, and colleagues have used genetic technologies and dru...

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Autores principales:	Jean-François Paré, Christopher J. Martyniuk, Michael Levin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/02efc15f62274d419645979beec788cf
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spelling	oai:doaj.org-article:02efc15f62274d419645979beec788cf2021-12-02T14:22:13ZBioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis10.1038/s41536-017-0019-y2057-3995https://doaj.org/article/02efc15f62274d419645979beec788cf2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0019-yhttps://doaj.org/toc/2057-3995Sparking immunity: Bioelectric signaling modulates immunity and regeneration Bioelectrical signaling in the African clawed frog modulates both resistance to infection and tail regeneration. Michael Levin at Tufts University in Massachusetts, USA, and colleagues have used genetic technologies and drug treatments to manipulate the bioelectrical properties of tissues in frog embryos. Reducing the electric gradient between the inside and outside of cells (depolarization) increased the embryos’ survival rate to bacterial infection, whereas increasing the resting potential (hyperpolarization) had the opposite effect. The authors found that serotonergic signaling and an increase in the number of myeloid cells underpin depolarization-induced immunity. Interestingly, embryos undergoing tail regeneration, which triggers depolarization, also showed increased resistance to infection. The role of bioelectrical signaling in both regeneration and immune response suggests that ion channel drugs, many already in medical use, could be useful for treating infection and severe physical injuries.Jean-François ParéChristopher J. MartyniukMichael LevinNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Jean-François Paré Christopher J. Martyniuk Michael Levin Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis
description	Sparking immunity: Bioelectric signaling modulates immunity and regeneration Bioelectrical signaling in the African clawed frog modulates both resistance to infection and tail regeneration. Michael Levin at Tufts University in Massachusetts, USA, and colleagues have used genetic technologies and drug treatments to manipulate the bioelectrical properties of tissues in frog embryos. Reducing the electric gradient between the inside and outside of cells (depolarization) increased the embryos’ survival rate to bacterial infection, whereas increasing the resting potential (hyperpolarization) had the opposite effect. The authors found that serotonergic signaling and an increase in the number of myeloid cells underpin depolarization-induced immunity. Interestingly, embryos undergoing tail regeneration, which triggers depolarization, also showed increased resistance to infection. The role of bioelectrical signaling in both regeneration and immune response suggests that ion channel drugs, many already in medical use, could be useful for treating infection and severe physical injuries.
format	article
author	Jean-François Paré Christopher J. Martyniuk Michael Levin
author_facet	Jean-François Paré Christopher J. Martyniuk Michael Levin
author_sort	Jean-François Paré
title	Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis
title_short	Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis
title_full	Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis
title_fullStr	Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis
title_full_unstemmed	Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis
title_sort	bioelectric regulation of innate immune system function in regenerating and intact xenopus laevis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/02efc15f62274d419645979beec788cf
work_keys_str_mv	AT jeanfrancoispare bioelectricregulationofinnateimmunesystemfunctioninregeneratingandintactxenopuslaevis AT christopherjmartyniuk bioelectricregulationofinnateimmunesystemfunctioninregeneratingandintactxenopuslaevis AT michaellevin bioelectricregulationofinnateimmunesystemfunctioninregeneratingandintactxenopuslaevis
_version_	1718391466451009536

Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis

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