Association of the polymorphism in the androgen receptor gene and endothelial function in men with type 2 diabetes

In recent years, actively studied the effect of androgen deficiency on the cardiovascular system, including endothelial function. Genomic effects of testosterone caused by the length of CAG repeats polymorphism in the androgen receptor (AR) gene.Aim. To examine the association of the polymorphism in...

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Autores principales:	Irina Alekseevna Khripun, Sergey Vladislavovich Vorobyev, Michael Iosifovich Kogan
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	androgen receptor gene cag-repeats in the ar gene testosterone endothelial dysfunction androgen deficiency type 2 diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/02f09edefa734c22a4e344937deebaef
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spelling	oai:doaj.org-article:02f09edefa734c22a4e344937deebaef2021-11-14T09:00:20ZAssociation of the polymorphism in the androgen receptor gene and endothelial function in men with type 2 diabetes2072-03512072-037810.14341/DM7622https://doaj.org/article/02f09edefa734c22a4e344937deebaef2015-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7622https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378In recent years, actively studied the effect of androgen deficiency on the cardiovascular system, including endothelial function. Genomic effects of testosterone caused by the length of CAG repeats polymorphism in the androgen receptor (AR) gene.Aim. To examine the association of the polymorphism in the AR gene and carbohydrate, lipid metabolism, endothelial function in men with type 2 diabetes.Materials and methods. We examined 88 men, aged 40-65 years (mean age 53±6,4years) with type 2 diabetes. All patients underwent the study of carbohydrate and lipid metabolism, the assessment of vasomotor endothelial function of the brachial artery by ultrasound sonography, were studied biochemical markers of endothelial dysfunction – ICAM-1, VCAM-1, p-selectin, e-selectin, resistin and number of CAG-repeats in the AR gene. Statistical analysis was performed using the application package SPSS 21,0 using regression analysis.Results. The number of CAG repeats had a significant positive regression to the level of total testosterone, a weak negative regression of the number of CAG repeats in the AR gene and lipid metabolism: triglycerides, LDL, atherogenic index. The assessment of the brachial artery ultrasonography revealed negative regression of the baseline brachial artery diameter and blood flow velocity in the endothelium-dependent vasodilation. The number of CAG repeats was significantly correlated with the levels of p-selectin and resistin. Thus, increasing the number of CAG repeats in the AR gene via a weakening of sensitivity to androgens leads to disruption of endothelial function in men with type 2 diabetes. Increasing the number of CAG repeats in the AR gene leads to deterioration of linear flow velocity during the test with reactive hyperemia with increasing production of p-selectin and resistin.Conclusions. The number of CAG repeats in the AR gene can be regarded as a predictor of the development and progression of cardiovascular lesions in men with type 2 diabetes.Irina Alekseevna KhripunSergey Vladislavovich VorobyevMichael Iosifovich KoganEndocrinology Research Centrearticleandrogen receptor genecag-repeats in the ar genetestosteroneendothelial dysfunctionandrogen deficiencytype 2 diabetes mellitusNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 4, Pp 35-40 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	androgen receptor gene cag-repeats in the ar gene testosterone endothelial dysfunction androgen deficiency type 2 diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	androgen receptor gene cag-repeats in the ar gene testosterone endothelial dysfunction androgen deficiency type 2 diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627 Irina Alekseevna Khripun Sergey Vladislavovich Vorobyev Michael Iosifovich Kogan Association of the polymorphism in the androgen receptor gene and endothelial function in men with type 2 diabetes
description	In recent years, actively studied the effect of androgen deficiency on the cardiovascular system, including endothelial function. Genomic effects of testosterone caused by the length of CAG repeats polymorphism in the androgen receptor (AR) gene.Aim. To examine the association of the polymorphism in the AR gene and carbohydrate, lipid metabolism, endothelial function in men with type 2 diabetes.Materials and methods. We examined 88 men, aged 40-65 years (mean age 53±6,4years) with type 2 diabetes. All patients underwent the study of carbohydrate and lipid metabolism, the assessment of vasomotor endothelial function of the brachial artery by ultrasound sonography, were studied biochemical markers of endothelial dysfunction – ICAM-1, VCAM-1, p-selectin, e-selectin, resistin and number of CAG-repeats in the AR gene. Statistical analysis was performed using the application package SPSS 21,0 using regression analysis.Results. The number of CAG repeats had a significant positive regression to the level of total testosterone, a weak negative regression of the number of CAG repeats in the AR gene and lipid metabolism: triglycerides, LDL, atherogenic index. The assessment of the brachial artery ultrasonography revealed negative regression of the baseline brachial artery diameter and blood flow velocity in the endothelium-dependent vasodilation. The number of CAG repeats was significantly correlated with the levels of p-selectin and resistin. Thus, increasing the number of CAG repeats in the AR gene via a weakening of sensitivity to androgens leads to disruption of endothelial function in men with type 2 diabetes. Increasing the number of CAG repeats in the AR gene leads to deterioration of linear flow velocity during the test with reactive hyperemia with increasing production of p-selectin and resistin.Conclusions. The number of CAG repeats in the AR gene can be regarded as a predictor of the development and progression of cardiovascular lesions in men with type 2 diabetes.
format	article
author	Irina Alekseevna Khripun Sergey Vladislavovich Vorobyev Michael Iosifovich Kogan
author_facet	Irina Alekseevna Khripun Sergey Vladislavovich Vorobyev Michael Iosifovich Kogan
author_sort	Irina Alekseevna Khripun
title	Association of the polymorphism in the androgen receptor gene and endothelial function in men with type 2 diabetes
title_short	Association of the polymorphism in the androgen receptor gene and endothelial function in men with type 2 diabetes
title_full	Association of the polymorphism in the androgen receptor gene and endothelial function in men with type 2 diabetes
title_fullStr	Association of the polymorphism in the androgen receptor gene and endothelial function in men with type 2 diabetes
title_full_unstemmed	Association of the polymorphism in the androgen receptor gene and endothelial function in men with type 2 diabetes
title_sort	association of the polymorphism in the androgen receptor gene and endothelial function in men with type 2 diabetes
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/02f09edefa734c22a4e344937deebaef
work_keys_str_mv	AT irinaalekseevnakhripun associationofthepolymorphismintheandrogenreceptorgeneandendothelialfunctioninmenwithtype2diabetes AT sergeyvladislavovichvorobyev associationofthepolymorphismintheandrogenreceptorgeneandendothelialfunctioninmenwithtype2diabetes AT michaeliosifovichkogan associationofthepolymorphismintheandrogenreceptorgeneandendothelialfunctioninmenwithtype2diabetes
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Association of the polymorphism in the androgen receptor gene and endothelial function in men with type 2 diabetes

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