Investigating PLGA microparticle swelling behavior reveals an interplay of expansive intermolecular forces

Abstract This study analyzes the swelling behavior of native, unmodified, spherically uniform, monodisperse poly(lactic-co-glycolic acid) (PLGA) microparticles in a robust high-throughput manner. This work contributes to the complex narrative of PLGA microparticle behavior and release mechanisms by...

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Autores principales:	Crystal E. Rapier, Kenneth J. Shea, Abraham P. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/02f2f6d148144b00b00c145be9e54037
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spelling	oai:doaj.org-article:02f2f6d148144b00b00c145be9e540372021-12-02T16:08:08ZInvestigating PLGA microparticle swelling behavior reveals an interplay of expansive intermolecular forces10.1038/s41598-021-93785-62045-2322https://doaj.org/article/02f2f6d148144b00b00c145be9e540372021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93785-6https://doaj.org/toc/2045-2322Abstract This study analyzes the swelling behavior of native, unmodified, spherically uniform, monodisperse poly(lactic-co-glycolic acid) (PLGA) microparticles in a robust high-throughput manner. This work contributes to the complex narrative of PLGA microparticle behavior and release mechanisms by complementing and extending previously reported studies on intraparticle microenvironment, degradation, and drug release. Microfluidically produced microparticles are incubated under physiological conditions and observed for 50 days to generate a profile of swelling behavior. Microparticles substantially increase in size after 15 days, continue increasing for 30 days achieving size dependent swelling indices between 49 and 83%. Swelling capacity is found to correlate with pH. Our study addresses questions such as onset, duration, swelling index, size dependency, reproducibility, and causal mechanistic forces surrounding swelling. Importantly, this study can serve as the basis for predictive modeling of microparticle behavior and swelling capacity, in addition to providing clues as to the microenvironmental conditions that encapsulated material may experience.Crystal E. RapierKenneth J. SheaAbraham P. LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Crystal E. Rapier Kenneth J. Shea Abraham P. Lee Investigating PLGA microparticle swelling behavior reveals an interplay of expansive intermolecular forces
description	Abstract This study analyzes the swelling behavior of native, unmodified, spherically uniform, monodisperse poly(lactic-co-glycolic acid) (PLGA) microparticles in a robust high-throughput manner. This work contributes to the complex narrative of PLGA microparticle behavior and release mechanisms by complementing and extending previously reported studies on intraparticle microenvironment, degradation, and drug release. Microfluidically produced microparticles are incubated under physiological conditions and observed for 50 days to generate a profile of swelling behavior. Microparticles substantially increase in size after 15 days, continue increasing for 30 days achieving size dependent swelling indices between 49 and 83%. Swelling capacity is found to correlate with pH. Our study addresses questions such as onset, duration, swelling index, size dependency, reproducibility, and causal mechanistic forces surrounding swelling. Importantly, this study can serve as the basis for predictive modeling of microparticle behavior and swelling capacity, in addition to providing clues as to the microenvironmental conditions that encapsulated material may experience.
format	article
author	Crystal E. Rapier Kenneth J. Shea Abraham P. Lee
author_facet	Crystal E. Rapier Kenneth J. Shea Abraham P. Lee
author_sort	Crystal E. Rapier
title	Investigating PLGA microparticle swelling behavior reveals an interplay of expansive intermolecular forces
title_short	Investigating PLGA microparticle swelling behavior reveals an interplay of expansive intermolecular forces
title_full	Investigating PLGA microparticle swelling behavior reveals an interplay of expansive intermolecular forces
title_fullStr	Investigating PLGA microparticle swelling behavior reveals an interplay of expansive intermolecular forces
title_full_unstemmed	Investigating PLGA microparticle swelling behavior reveals an interplay of expansive intermolecular forces
title_sort	investigating plga microparticle swelling behavior reveals an interplay of expansive intermolecular forces
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/02f2f6d148144b00b00c145be9e54037
work_keys_str_mv	AT crystalerapier investigatingplgamicroparticleswellingbehaviorrevealsaninterplayofexpansiveintermolecularforces AT kennethjshea investigatingplgamicroparticleswellingbehaviorrevealsaninterplayofexpansiveintermolecularforces AT abrahamplee investigatingplgamicroparticleswellingbehaviorrevealsaninterplayofexpansiveintermolecularforces
_version_	1718384573393403904

Investigating PLGA microparticle swelling behavior reveals an interplay of expansive intermolecular forces

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