Alteration of the gut microbiota in rhesus monkey with spontaneous osteoarthritis

Abstract Background The spontaneous osteoarthritis (OA) in rhesus macaque is similar to OA in human, which maintains an upright body posture and shows very similar biomechanical properties of bones to humans. At present, there is no good treatment for OA. This study aims to explore relationship betw...

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Autores principales:	Yaping Yan, Xiaoyan Yi, Yanchao Duan, Bin Jiang, Tianzhuang Huang, Briauna Marie Inglis, Bingrong Zheng, Wei Si
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Spontaneous osteoarthritis Rhesus macaque Gut microbiota Cartilage damage Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/02f3fbd60249430b9f52062dbcb7bd93
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spelling	oai:doaj.org-article:02f3fbd60249430b9f52062dbcb7bd932021-11-28T12:07:12ZAlteration of the gut microbiota in rhesus monkey with spontaneous osteoarthritis10.1186/s12866-021-02390-01471-2180https://doaj.org/article/02f3fbd60249430b9f52062dbcb7bd932021-11-01T00:00:00Zhttps://doi.org/10.1186/s12866-021-02390-0https://doaj.org/toc/1471-2180Abstract Background The spontaneous osteoarthritis (OA) in rhesus macaque is similar to OA in human, which maintains an upright body posture and shows very similar biomechanical properties of bones to humans. At present, there is no good treatment for OA. This study aims to explore relationship between OA and intestinal microbiota, and provide a reference for the treatment of clinical OA. Results We collected colonic contents of the 20 rhesus macaque (6–15 years old, female) for intestinal microbiota analysis by metagenomics sequencing, of which 10 were spontaneous OA monkeys and 10 were normal monkeys. Our results showed the diversity of gut microbiota in monkeys with OA was decreased compared to the normal monkeys (p = 0.16). Mollicutes, Tenericutes, Coprobacillus and Faecalitalea may be biomarkers for the monkeys of OA. Lactobacillus found significantly increased in OA monkeys. Prevotella and Ruminococcus were higher in the normal group than OA group. Zinc/manganese transport system permease protein (p = 0.0011) and Cyclopropane-fatty-acyl-phospholipid synthase (p = 0.0012) are a microbiota metabolic pathway related to cartilage production. Conclusions Our results indicate that the diversity and composition of intestinal microbiota in monkeys with OA are different compared to the normal monkeys. we have found microbes that may be a biomarker for the diagnosis of osteoarthritis. Functional analysis of the microbiota also predicts cartilage damage in the monkeys with osteoarthritis. Non-human primates are closely related to humans, so this study can provide a reference for the development of drugs for the treatment of OA.Yaping YanXiaoyan YiYanchao DuanBin JiangTianzhuang HuangBriauna Marie InglisBingrong ZhengWei SiBMCarticleSpontaneous osteoarthritisRhesus macaqueGut microbiotaCartilage damageMicrobiologyQR1-502ENBMC Microbiology, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Spontaneous osteoarthritis Rhesus macaque Gut microbiota Cartilage damage Microbiology QR1-502
spellingShingle	Spontaneous osteoarthritis Rhesus macaque Gut microbiota Cartilage damage Microbiology QR1-502 Yaping Yan Xiaoyan Yi Yanchao Duan Bin Jiang Tianzhuang Huang Briauna Marie Inglis Bingrong Zheng Wei Si Alteration of the gut microbiota in rhesus monkey with spontaneous osteoarthritis
description	Abstract Background The spontaneous osteoarthritis (OA) in rhesus macaque is similar to OA in human, which maintains an upright body posture and shows very similar biomechanical properties of bones to humans. At present, there is no good treatment for OA. This study aims to explore relationship between OA and intestinal microbiota, and provide a reference for the treatment of clinical OA. Results We collected colonic contents of the 20 rhesus macaque (6–15 years old, female) for intestinal microbiota analysis by metagenomics sequencing, of which 10 were spontaneous OA monkeys and 10 were normal monkeys. Our results showed the diversity of gut microbiota in monkeys with OA was decreased compared to the normal monkeys (p = 0.16). Mollicutes, Tenericutes, Coprobacillus and Faecalitalea may be biomarkers for the monkeys of OA. Lactobacillus found significantly increased in OA monkeys. Prevotella and Ruminococcus were higher in the normal group than OA group. Zinc/manganese transport system permease protein (p = 0.0011) and Cyclopropane-fatty-acyl-phospholipid synthase (p = 0.0012) are a microbiota metabolic pathway related to cartilage production. Conclusions Our results indicate that the diversity and composition of intestinal microbiota in monkeys with OA are different compared to the normal monkeys. we have found microbes that may be a biomarker for the diagnosis of osteoarthritis. Functional analysis of the microbiota also predicts cartilage damage in the monkeys with osteoarthritis. Non-human primates are closely related to humans, so this study can provide a reference for the development of drugs for the treatment of OA.
format	article
author	Yaping Yan Xiaoyan Yi Yanchao Duan Bin Jiang Tianzhuang Huang Briauna Marie Inglis Bingrong Zheng Wei Si
author_facet	Yaping Yan Xiaoyan Yi Yanchao Duan Bin Jiang Tianzhuang Huang Briauna Marie Inglis Bingrong Zheng Wei Si
author_sort	Yaping Yan
title	Alteration of the gut microbiota in rhesus monkey with spontaneous osteoarthritis
title_short	Alteration of the gut microbiota in rhesus monkey with spontaneous osteoarthritis
title_full	Alteration of the gut microbiota in rhesus monkey with spontaneous osteoarthritis
title_fullStr	Alteration of the gut microbiota in rhesus monkey with spontaneous osteoarthritis
title_full_unstemmed	Alteration of the gut microbiota in rhesus monkey with spontaneous osteoarthritis
title_sort	alteration of the gut microbiota in rhesus monkey with spontaneous osteoarthritis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/02f3fbd60249430b9f52062dbcb7bd93
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Alteration of the gut microbiota in rhesus monkey with spontaneous osteoarthritis

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