Identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1.
<h4>Objectives</h4>We hypothesised that assessment of plasma C-terminal pro-endothelin-1 (CT-proET-1), a stable endothelin-1 precursor fragment, is of prognostic value in patients with chronic heart failure (CHF), beyond other prognosticators, including N-terminal pro-B-type natriuretic...
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2011
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oai:doaj.org-article:02f7cba586b447cea8b2f164df4c7e8a2021-11-18T07:00:25ZIdentification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1.1932-620310.1371/journal.pone.0014506https://doaj.org/article/02f7cba586b447cea8b2f164df4c7e8a2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21264211/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>We hypothesised that assessment of plasma C-terminal pro-endothelin-1 (CT-proET-1), a stable endothelin-1 precursor fragment, is of prognostic value in patients with chronic heart failure (CHF), beyond other prognosticators, including N-terminal pro-B-type natriuretic peptide (NT-proBNP).<h4>Methods</h4>We examined 491 patients with systolic CHF (age: 63±11 years, 91% men, New York Heart Association [NYHA] class [I/II/III/IV]: 9%/45%/38%/8%, 69% ischemic etiology). Plasma CT-proET-1 was detected using a chemiluminescence immunoassay.<h4>Results</h4>Increasing CT-proET-1 was a predictor of increased cardiovascular mortality at 12-months of follow-up (standardized hazard ratio 1.42, 95% confidence interval [CI] 1.04-1.95, p = 0.03) after adjusting for NT-proBNP, left ventricular ejection fraction (LVEF), age, creatinine, NYHA class. In receiver operating characteristic curve analysis, areas under curve for 12-month follow-up were similar for CT-proET-1 and NT-proBNP (p = 0.40). Both NT-proBNP and CT-proET-1 added prognostic value to a base model that included LVEF, age, creatinine, and NYHA class. Adding CT-proET-1 to the base model had stronger prognostic power (p<0.01) than adding NT-proBNP (p<0.01). Adding CT-proET-1 to NT-proBNP in this model yielded further prognostic information (p = 0.02).<h4>Conclusions</h4>Plasma CT-proET-1 constitutes a novel predictor of increased 12-month cardiovascular mortality in patients with CHF. High CT-proET-1 together with high NT-proBNP enable to identify patients with CHF and particularly unfavourable outcomes.Ewa A JankowskaGerasimos S FilippatosStephan von HaehlingJana PapassotiriouNils G MorgenthalerMariantonietta CicoiraJoerg C SchefoldPiotr RozentrytBeata PonikowskaWolfram DoehnerWaldemar BanasiakOliver HartmannJoachim StruckAndreas BergmannStefan D AnkerPiotr PonikowskiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 1, p e14506 (2011) |
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Medicine R Science Q |
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Medicine R Science Q Ewa A Jankowska Gerasimos S Filippatos Stephan von Haehling Jana Papassotiriou Nils G Morgenthaler Mariantonietta Cicoira Joerg C Schefold Piotr Rozentryt Beata Ponikowska Wolfram Doehner Waldemar Banasiak Oliver Hartmann Joachim Struck Andreas Bergmann Stefan D Anker Piotr Ponikowski Identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1. |
| description |
<h4>Objectives</h4>We hypothesised that assessment of plasma C-terminal pro-endothelin-1 (CT-proET-1), a stable endothelin-1 precursor fragment, is of prognostic value in patients with chronic heart failure (CHF), beyond other prognosticators, including N-terminal pro-B-type natriuretic peptide (NT-proBNP).<h4>Methods</h4>We examined 491 patients with systolic CHF (age: 63±11 years, 91% men, New York Heart Association [NYHA] class [I/II/III/IV]: 9%/45%/38%/8%, 69% ischemic etiology). Plasma CT-proET-1 was detected using a chemiluminescence immunoassay.<h4>Results</h4>Increasing CT-proET-1 was a predictor of increased cardiovascular mortality at 12-months of follow-up (standardized hazard ratio 1.42, 95% confidence interval [CI] 1.04-1.95, p = 0.03) after adjusting for NT-proBNP, left ventricular ejection fraction (LVEF), age, creatinine, NYHA class. In receiver operating characteristic curve analysis, areas under curve for 12-month follow-up were similar for CT-proET-1 and NT-proBNP (p = 0.40). Both NT-proBNP and CT-proET-1 added prognostic value to a base model that included LVEF, age, creatinine, and NYHA class. Adding CT-proET-1 to the base model had stronger prognostic power (p<0.01) than adding NT-proBNP (p<0.01). Adding CT-proET-1 to NT-proBNP in this model yielded further prognostic information (p = 0.02).<h4>Conclusions</h4>Plasma CT-proET-1 constitutes a novel predictor of increased 12-month cardiovascular mortality in patients with CHF. High CT-proET-1 together with high NT-proBNP enable to identify patients with CHF and particularly unfavourable outcomes. |
| format |
article |
| author |
Ewa A Jankowska Gerasimos S Filippatos Stephan von Haehling Jana Papassotiriou Nils G Morgenthaler Mariantonietta Cicoira Joerg C Schefold Piotr Rozentryt Beata Ponikowska Wolfram Doehner Waldemar Banasiak Oliver Hartmann Joachim Struck Andreas Bergmann Stefan D Anker Piotr Ponikowski |
| author_facet |
Ewa A Jankowska Gerasimos S Filippatos Stephan von Haehling Jana Papassotiriou Nils G Morgenthaler Mariantonietta Cicoira Joerg C Schefold Piotr Rozentryt Beata Ponikowska Wolfram Doehner Waldemar Banasiak Oliver Hartmann Joachim Struck Andreas Bergmann Stefan D Anker Piotr Ponikowski |
| author_sort |
Ewa A Jankowska |
| title |
Identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1. |
| title_short |
Identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1. |
| title_full |
Identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1. |
| title_fullStr |
Identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1. |
| title_full_unstemmed |
Identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1. |
| title_sort |
identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma c-terminal pro-endothelin-1. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/02f7cba586b447cea8b2f164df4c7e8a |
| work_keys_str_mv |
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1718424019043090432 |