Mapping allosteric communications within individual proteins

The computational prediction of protein allostery can guide experimental studies of protein function and cellular activity. Here, the authors develop a network-based method to detect allosteric coupling within proteins solely based on their structures, and set up a webserver for allostery prediction...

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Autores principales:	Jian Wang, Abha Jain, Leanna R. McDonald, Craig Gambogi, Andrew L. Lee, Nikolay V. Dokholyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/02fe4867530c4119b85459cc38ba7e72
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spelling	oai:doaj.org-article:02fe4867530c4119b85459cc38ba7e722021-12-02T18:47:08ZMapping allosteric communications within individual proteins10.1038/s41467-020-17618-22041-1723https://doaj.org/article/02fe4867530c4119b85459cc38ba7e722020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17618-2https://doaj.org/toc/2041-1723The computational prediction of protein allostery can guide experimental studies of protein function and cellular activity. Here, the authors develop a network-based method to detect allosteric coupling within proteins solely based on their structures, and set up a webserver for allostery prediction.Jian WangAbha JainLeanna R. McDonaldCraig GambogiAndrew L. LeeNikolay V. DokholyanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian Wang Abha Jain Leanna R. McDonald Craig Gambogi Andrew L. Lee Nikolay V. Dokholyan Mapping allosteric communications within individual proteins
description	The computational prediction of protein allostery can guide experimental studies of protein function and cellular activity. Here, the authors develop a network-based method to detect allosteric coupling within proteins solely based on their structures, and set up a webserver for allostery prediction.
format	article
author	Jian Wang Abha Jain Leanna R. McDonald Craig Gambogi Andrew L. Lee Nikolay V. Dokholyan
author_facet	Jian Wang Abha Jain Leanna R. McDonald Craig Gambogi Andrew L. Lee Nikolay V. Dokholyan
author_sort	Jian Wang
title	Mapping allosteric communications within individual proteins
title_short	Mapping allosteric communications within individual proteins
title_full	Mapping allosteric communications within individual proteins
title_fullStr	Mapping allosteric communications within individual proteins
title_full_unstemmed	Mapping allosteric communications within individual proteins
title_sort	mapping allosteric communications within individual proteins
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/02fe4867530c4119b85459cc38ba7e72
work_keys_str_mv	AT jianwang mappingallostericcommunicationswithinindividualproteins AT abhajain mappingallostericcommunicationswithinindividualproteins AT leannarmcdonald mappingallostericcommunicationswithinindividualproteins AT craiggambogi mappingallostericcommunicationswithinindividualproteins AT andrewllee mappingallostericcommunicationswithinindividualproteins AT nikolayvdokholyan mappingallostericcommunicationswithinindividualproteins
_version_	1718377660996911104

Mapping allosteric communications within individual proteins

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