Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels

Regulatory T (Treg) cells are important for maintaining immune homeostasis. Here the authors show that STIM1 and STIM2, which activate the Ca2+ channel ORAI1, are essential for the differentiation of peripheral Treg cells into tissue-resident and follicular Treg cells and their ability to limit auto...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Martin Vaeth, Yin-Hu Wang, Miriam Eckstein, Jun Yang, Gregg J. Silverman, Rodrigo S. Lacruz, Kasthuri Kannan, Stefan Feske
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0300d7db026b4d60913b2983240f24ef
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0300d7db026b4d60913b2983240f24ef
record_format	dspace
spelling	oai:doaj.org-article:0300d7db026b4d60913b2983240f24ef2021-12-02T17:02:17ZTissue resident and follicular Treg cell differentiation is regulated by CRAC channels10.1038/s41467-019-08959-82041-1723https://doaj.org/article/0300d7db026b4d60913b2983240f24ef2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08959-8https://doaj.org/toc/2041-1723Regulatory T (Treg) cells are important for maintaining immune homeostasis. Here the authors show that STIM1 and STIM2, which activate the Ca2+ channel ORAI1, are essential for the differentiation of peripheral Treg cells into tissue-resident and follicular Treg cells and their ability to limit autoimmunity in mice.Martin VaethYin-Hu WangMiriam EcksteinJun YangGregg J. SilvermanRodrigo S. LacruzKasthuri KannanStefan FeskeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Vaeth Yin-Hu Wang Miriam Eckstein Jun Yang Gregg J. Silverman Rodrigo S. Lacruz Kasthuri Kannan Stefan Feske Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
description	Regulatory T (Treg) cells are important for maintaining immune homeostasis. Here the authors show that STIM1 and STIM2, which activate the Ca2+ channel ORAI1, are essential for the differentiation of peripheral Treg cells into tissue-resident and follicular Treg cells and their ability to limit autoimmunity in mice.
format	article
author	Martin Vaeth Yin-Hu Wang Miriam Eckstein Jun Yang Gregg J. Silverman Rodrigo S. Lacruz Kasthuri Kannan Stefan Feske
author_facet	Martin Vaeth Yin-Hu Wang Miriam Eckstein Jun Yang Gregg J. Silverman Rodrigo S. Lacruz Kasthuri Kannan Stefan Feske
author_sort	Martin Vaeth
title	Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
title_short	Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
title_full	Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
title_fullStr	Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
title_full_unstemmed	Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
title_sort	tissue resident and follicular treg cell differentiation is regulated by crac channels
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0300d7db026b4d60913b2983240f24ef
work_keys_str_mv	AT martinvaeth tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels AT yinhuwang tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels AT miriameckstein tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels AT junyang tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels AT greggjsilverman tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels AT rodrigoslacruz tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels AT kasthurikannan tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels AT stefanfeske tissueresidentandfolliculartregcelldifferentiationisregulatedbycracchannels
_version_	1718381888590053376

Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels

Ejemplares similares