Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels

Regulatory T (Treg) cells are important for maintaining immune homeostasis. Here the authors show that STIM1 and STIM2, which activate the Ca2+ channel ORAI1, are essential for the differentiation of peripheral Treg cells into tissue-resident and follicular Treg cells and their ability to limit auto...

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Autores principales: Martin Vaeth, Yin-Hu Wang, Miriam Eckstein, Jun Yang, Gregg J. Silverman, Rodrigo S. Lacruz, Kasthuri Kannan, Stefan Feske
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/0300d7db026b4d60913b2983240f24ef
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