In-vivo impact of common cosmetic preservative systems in full formulation on the skin microbiome.

Preservatives play an essentially role in ensuring that cosmetic formulations remain safe for use via control of microbial contamination. Commonly used preservatives include organic acids, alcohols and phenols and these play an essential role in controlling the growth of bacteria, fungi and moulds i...

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Autores principales:	Barry Murphy, Michael Hoptroff, David Arnold, Richard Eccles, Stuart Campbell-Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/03066686ddbf42dcae36a248c9f6b553
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spelling	oai:doaj.org-article:03066686ddbf42dcae36a248c9f6b5532021-12-02T20:15:34ZIn-vivo impact of common cosmetic preservative systems in full formulation on the skin microbiome.1932-620310.1371/journal.pone.0254172https://doaj.org/article/03066686ddbf42dcae36a248c9f6b5532021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254172https://doaj.org/toc/1932-6203Preservatives play an essentially role in ensuring that cosmetic formulations remain safe for use via control of microbial contamination. Commonly used preservatives include organic acids, alcohols and phenols and these play an essential role in controlling the growth of bacteria, fungi and moulds in substrates that can potentially act as a rich food source for microbial contaminants. Whilst the activity of these compounds is clear, both in vitro and in formulation, little information exists on the potential impact that common preservative systems, in full formulation, have on the skin's resident microbiome. Dysbiosis of the skin's microbiome has been associated with a number of cosmetic conditions but there currently are no in vivo studies investigating the potential for preservative ingredients, when included in personal care formulations under normal use conditions, to impact the cutaneous microbiome. Here we present an analysis of four in vivo studies that examine the impact of different preservation systems in full formulation, in different products formats, with varying durations of application. This work demonstrates that despite the antimicrobial efficacy of the preservatives in vitro, the skin microbiome is not impacted by preservative containing products in vivo.Barry MurphyMichael HoptroffDavid ArnoldRichard EcclesStuart Campbell-LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254172 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Barry Murphy Michael Hoptroff David Arnold Richard Eccles Stuart Campbell-Lee In-vivo impact of common cosmetic preservative systems in full formulation on the skin microbiome.
description	Preservatives play an essentially role in ensuring that cosmetic formulations remain safe for use via control of microbial contamination. Commonly used preservatives include organic acids, alcohols and phenols and these play an essential role in controlling the growth of bacteria, fungi and moulds in substrates that can potentially act as a rich food source for microbial contaminants. Whilst the activity of these compounds is clear, both in vitro and in formulation, little information exists on the potential impact that common preservative systems, in full formulation, have on the skin's resident microbiome. Dysbiosis of the skin's microbiome has been associated with a number of cosmetic conditions but there currently are no in vivo studies investigating the potential for preservative ingredients, when included in personal care formulations under normal use conditions, to impact the cutaneous microbiome. Here we present an analysis of four in vivo studies that examine the impact of different preservation systems in full formulation, in different products formats, with varying durations of application. This work demonstrates that despite the antimicrobial efficacy of the preservatives in vitro, the skin microbiome is not impacted by preservative containing products in vivo.
format	article
author	Barry Murphy Michael Hoptroff David Arnold Richard Eccles Stuart Campbell-Lee
author_facet	Barry Murphy Michael Hoptroff David Arnold Richard Eccles Stuart Campbell-Lee
author_sort	Barry Murphy
title	In-vivo impact of common cosmetic preservative systems in full formulation on the skin microbiome.
title_short	In-vivo impact of common cosmetic preservative systems in full formulation on the skin microbiome.
title_full	In-vivo impact of common cosmetic preservative systems in full formulation on the skin microbiome.
title_fullStr	In-vivo impact of common cosmetic preservative systems in full formulation on the skin microbiome.
title_full_unstemmed	In-vivo impact of common cosmetic preservative systems in full formulation on the skin microbiome.
title_sort	in-vivo impact of common cosmetic preservative systems in full formulation on the skin microbiome.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/03066686ddbf42dcae36a248c9f6b553
work_keys_str_mv	AT barrymurphy invivoimpactofcommoncosmeticpreservativesystemsinfullformulationontheskinmicrobiome AT michaelhoptroff invivoimpactofcommoncosmeticpreservativesystemsinfullformulationontheskinmicrobiome AT davidarnold invivoimpactofcommoncosmeticpreservativesystemsinfullformulationontheskinmicrobiome AT richardeccles invivoimpactofcommoncosmeticpreservativesystemsinfullformulationontheskinmicrobiome AT stuartcampbelllee invivoimpactofcommoncosmeticpreservativesystemsinfullformulationontheskinmicrobiome
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In-vivo impact of common cosmetic preservative systems in full formulation on the skin microbiome.

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