USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7

Though ubiquitin is known to broadly influence endosomal trafficking, few ubiquitin-utilizing enzymes targeting endosomal regulators are known. Here, the authors find that the deubiquitylating enzyme (DUB) USP32 influences endosomal membrane dynamics by deubiquitinating Rab7.

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Autores principales:	Aysegul Sapmaz, Ilana Berlin, Erik Bos, Ruud H. Wijdeven, Hans Janssen, Rebecca Konietzny, Jimmy J. Akkermans, Ayse E. Erson-Bensan, Roman I. Koning, Benedikt M. Kessler, Jacques Neefjes, Huib Ovaa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03097ad9b5bc4f32abfc5298bf844d05
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spelling	oai:doaj.org-article:03097ad9b5bc4f32abfc5298bf844d052021-12-02T14:38:59ZUSP32 regulates late endosomal transport and recycling through deubiquitylation of Rab710.1038/s41467-019-09437-x2041-1723https://doaj.org/article/03097ad9b5bc4f32abfc5298bf844d052019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09437-xhttps://doaj.org/toc/2041-1723Though ubiquitin is known to broadly influence endosomal trafficking, few ubiquitin-utilizing enzymes targeting endosomal regulators are known. Here, the authors find that the deubiquitylating enzyme (DUB) USP32 influences endosomal membrane dynamics by deubiquitinating Rab7.Aysegul SapmazIlana BerlinErik BosRuud H. WijdevenHans JanssenRebecca KonietznyJimmy J. AkkermansAyse E. Erson-BensanRoman I. KoningBenedikt M. KesslerJacques NeefjesHuib OvaaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aysegul Sapmaz Ilana Berlin Erik Bos Ruud H. Wijdeven Hans Janssen Rebecca Konietzny Jimmy J. Akkermans Ayse E. Erson-Bensan Roman I. Koning Benedikt M. Kessler Jacques Neefjes Huib Ovaa USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7
description	Though ubiquitin is known to broadly influence endosomal trafficking, few ubiquitin-utilizing enzymes targeting endosomal regulators are known. Here, the authors find that the deubiquitylating enzyme (DUB) USP32 influences endosomal membrane dynamics by deubiquitinating Rab7.
format	article
author	Aysegul Sapmaz Ilana Berlin Erik Bos Ruud H. Wijdeven Hans Janssen Rebecca Konietzny Jimmy J. Akkermans Ayse E. Erson-Bensan Roman I. Koning Benedikt M. Kessler Jacques Neefjes Huib Ovaa
author_facet	Aysegul Sapmaz Ilana Berlin Erik Bos Ruud H. Wijdeven Hans Janssen Rebecca Konietzny Jimmy J. Akkermans Ayse E. Erson-Bensan Roman I. Koning Benedikt M. Kessler Jacques Neefjes Huib Ovaa
author_sort	Aysegul Sapmaz
title	USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7
title_short	USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7
title_full	USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7
title_fullStr	USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7
title_full_unstemmed	USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7
title_sort	usp32 regulates late endosomal transport and recycling through deubiquitylation of rab7
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/03097ad9b5bc4f32abfc5298bf844d05
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USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7

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