Peripheral Lymphocyte Subsets Absolute Counts as Feasible Clinical Markers for Predicting Surgical Outcome in Gastric Cancer Patients After Laparoscopic D2 Gastrectomy: A Prospective Cohort Study

Ci Dian Dan Zeng, Yi Xin Tong, Ai Tang Xiao, Chun Gao, Sheng Zhang Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Chun Gao; Sheng Zhang Email gaochun75@hotmail.com; aloof...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dan Zeng CD, Tong YX, Xiao AT, Gao C, Zhang S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	gastric cancer peripheral lymphocyte subsets absolute counts immune function surgical outcome inflammatory cytokines Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/030af47a6de84431967f7b97285e17e1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:030af47a6de84431967f7b97285e17e1
record_format	dspace
spelling	oai:doaj.org-article:030af47a6de84431967f7b97285e17e12021-12-02T17:50:48ZPeripheral Lymphocyte Subsets Absolute Counts as Feasible Clinical Markers for Predicting Surgical Outcome in Gastric Cancer Patients After Laparoscopic D2 Gastrectomy: A Prospective Cohort Study1178-7031https://doaj.org/article/030af47a6de84431967f7b97285e17e12021-10-01T00:00:00Zhttps://www.dovepress.com/peripheral-lymphocyte-subsets-absolute-counts-as-feasible-clinical-mar-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Ci Dian Dan Zeng, Yi Xin Tong, Ai Tang Xiao, Chun Gao, Sheng Zhang Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Chun Gao; Sheng Zhang Email gaochun75@hotmail.com; aloof3737@126.comBackground: Immune function influenced patients’ recovery from major abdominal surgery. The aim of this study is to explore the clinical feasibility of peripheral lymphocyte absolute counts for predicting short-term surgical outcomes in gastric cancer patients after laparoscopic D2 gastrectomy.Methods: This is a prospective cohort study from a single tertiary referral hospital. Patients diagnosed with gastric cancer who met the inclusion criteria were included in this study. We collected the demographic and clinicopathological characteristics of included patients. We monitored perioperative dynamics of absolute counts of peripheral lymphocyte subsets. Predictive factors for length of postoperative hospital stay and complications were investigated in univariate and multivariate analyses.Results: A total of 137 gastric cancer patients were included. Decreased preoperative absolute counts of peripheral lymphocyte subsets were correlated with advanced clinical stage. In multivariate analysis, independent predictive factors for prolonged hospital stay were age (p=0.04), decreased preoperative B cell counts (p=0.05), decreased preoperative NK cell counts (p=0.05) and complications (p< 0.01). For postoperative complication, independent predictive factors were age (p=0.02), operation time (p=0.05), lymphocyte to C-reactive protein ratio (p=0.01) and decreased preoperative B cell counts (p=0.01).Conclusion: Our findings for the first time revealed that absolute counts of peripheral lymphocyte subsets are independent predictive factors for surgical outcomes in gastric cancer patients after D2 gastrectomy. We suggested that patients with impaired immune state should receive both preoperative immune modulator and nutritional support.Keywords: gastric cancer, absolute counts of peripheral lymphocyte subsets, immune function, surgical outcome, inflammatory cytokinesDan Zeng CDTong YXXiao ATGao CZhang SDove Medical Pressarticlegastric cancerperipheral lymphocyte subsets absolute countsimmune functionsurgical outcomeinflammatory cytokinesPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 5633-5646 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric cancer peripheral lymphocyte subsets absolute counts immune function surgical outcome inflammatory cytokines Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	gastric cancer peripheral lymphocyte subsets absolute counts immune function surgical outcome inflammatory cytokines Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Dan Zeng CD Tong YX Xiao AT Gao C Zhang S Peripheral Lymphocyte Subsets Absolute Counts as Feasible Clinical Markers for Predicting Surgical Outcome in Gastric Cancer Patients After Laparoscopic D2 Gastrectomy: A Prospective Cohort Study
description	Ci Dian Dan Zeng, Yi Xin Tong, Ai Tang Xiao, Chun Gao, Sheng Zhang Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Chun Gao; Sheng Zhang Email gaochun75@hotmail.com; aloof3737@126.comBackground: Immune function influenced patients’ recovery from major abdominal surgery. The aim of this study is to explore the clinical feasibility of peripheral lymphocyte absolute counts for predicting short-term surgical outcomes in gastric cancer patients after laparoscopic D2 gastrectomy.Methods: This is a prospective cohort study from a single tertiary referral hospital. Patients diagnosed with gastric cancer who met the inclusion criteria were included in this study. We collected the demographic and clinicopathological characteristics of included patients. We monitored perioperative dynamics of absolute counts of peripheral lymphocyte subsets. Predictive factors for length of postoperative hospital stay and complications were investigated in univariate and multivariate analyses.Results: A total of 137 gastric cancer patients were included. Decreased preoperative absolute counts of peripheral lymphocyte subsets were correlated with advanced clinical stage. In multivariate analysis, independent predictive factors for prolonged hospital stay were age (p=0.04), decreased preoperative B cell counts (p=0.05), decreased preoperative NK cell counts (p=0.05) and complications (p< 0.01). For postoperative complication, independent predictive factors were age (p=0.02), operation time (p=0.05), lymphocyte to C-reactive protein ratio (p=0.01) and decreased preoperative B cell counts (p=0.01).Conclusion: Our findings for the first time revealed that absolute counts of peripheral lymphocyte subsets are independent predictive factors for surgical outcomes in gastric cancer patients after D2 gastrectomy. We suggested that patients with impaired immune state should receive both preoperative immune modulator and nutritional support.Keywords: gastric cancer, absolute counts of peripheral lymphocyte subsets, immune function, surgical outcome, inflammatory cytokines
format	article
author	Dan Zeng CD Tong YX Xiao AT Gao C Zhang S
author_facet	Dan Zeng CD Tong YX Xiao AT Gao C Zhang S
author_sort	Dan Zeng CD
title	Peripheral Lymphocyte Subsets Absolute Counts as Feasible Clinical Markers for Predicting Surgical Outcome in Gastric Cancer Patients After Laparoscopic D2 Gastrectomy: A Prospective Cohort Study
title_short	Peripheral Lymphocyte Subsets Absolute Counts as Feasible Clinical Markers for Predicting Surgical Outcome in Gastric Cancer Patients After Laparoscopic D2 Gastrectomy: A Prospective Cohort Study
title_full	Peripheral Lymphocyte Subsets Absolute Counts as Feasible Clinical Markers for Predicting Surgical Outcome in Gastric Cancer Patients After Laparoscopic D2 Gastrectomy: A Prospective Cohort Study
title_fullStr	Peripheral Lymphocyte Subsets Absolute Counts as Feasible Clinical Markers for Predicting Surgical Outcome in Gastric Cancer Patients After Laparoscopic D2 Gastrectomy: A Prospective Cohort Study
title_full_unstemmed	Peripheral Lymphocyte Subsets Absolute Counts as Feasible Clinical Markers for Predicting Surgical Outcome in Gastric Cancer Patients After Laparoscopic D2 Gastrectomy: A Prospective Cohort Study
title_sort	peripheral lymphocyte subsets absolute counts as feasible clinical markers for predicting surgical outcome in gastric cancer patients after laparoscopic d2 gastrectomy: a prospective cohort study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/030af47a6de84431967f7b97285e17e1
work_keys_str_mv	AT danzengcd peripherallymphocytesubsetsabsolutecountsasfeasibleclinicalmarkersforpredictingsurgicaloutcomeingastriccancerpatientsafterlaparoscopicd2gastrectomyaprospectivecohortstudy AT tongyx peripherallymphocytesubsetsabsolutecountsasfeasibleclinicalmarkersforpredictingsurgicaloutcomeingastriccancerpatientsafterlaparoscopicd2gastrectomyaprospectivecohortstudy AT xiaoat peripherallymphocytesubsetsabsolutecountsasfeasibleclinicalmarkersforpredictingsurgicaloutcomeingastriccancerpatientsafterlaparoscopicd2gastrectomyaprospectivecohortstudy AT gaoc peripherallymphocytesubsetsabsolutecountsasfeasibleclinicalmarkersforpredictingsurgicaloutcomeingastriccancerpatientsafterlaparoscopicd2gastrectomyaprospectivecohortstudy AT zhangs peripherallymphocytesubsetsabsolutecountsasfeasibleclinicalmarkersforpredictingsurgicaloutcomeingastriccancerpatientsafterlaparoscopicd2gastrectomyaprospectivecohortstudy
_version_	1718379268121034752

Peripheral Lymphocyte Subsets Absolute Counts as Feasible Clinical Markers for Predicting Surgical Outcome in Gastric Cancer Patients After Laparoscopic D2 Gastrectomy: A Prospective Cohort Study

Ejemplares similares