Association between maternal hepatitis B virus carrier and gestational diabetes mellitus: a retrospective cohort analysis
Abstract Introduction Given that many pregnant women have chronic hepatitis B virus (HBV) infection and that gestational diabetes mellitus (GDM) is linked to poor maternal and neonatal outcomes, we looked into the relationship between the hepatitis B surface antigen (HBsAg) and GDM to see if a high...
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2021
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oai:doaj.org-article:030be16c14f44a908433b5dd4770b0612021-11-21T12:02:09ZAssociation between maternal hepatitis B virus carrier and gestational diabetes mellitus: a retrospective cohort analysis10.1186/s12985-021-01691-01743-422Xhttps://doaj.org/article/030be16c14f44a908433b5dd4770b0612021-11-01T00:00:00Zhttps://doi.org/10.1186/s12985-021-01691-0https://doaj.org/toc/1743-422XAbstract Introduction Given that many pregnant women have chronic hepatitis B virus (HBV) infection and that gestational diabetes mellitus (GDM) is linked to poor maternal and neonatal outcomes, we looked into the relationship between the hepatitis B surface antigen (HBsAg) and GDM to see if a high HBV DNA load is linked to a higher risk of GDM in chronic maternal HBsAg carriers. Materials and methods Our study included 39,539 pregnant women who gave birth at the Third Affiliated Hospital of Guangzhou Medical University in Guangzhou, China, between January 1, 2009, and December 31, 2019. The patients were divided into two groups: HBsAg negative (36,500) and positive (3039). The viral load levels of 1250 HBsAg-positive women who had tested their HBV DNA load during pregnancy were separated into three groups. We utilized univariate and multivariable logistical regression analysis to determine the relationship between maternal chronic HBsAg carrier and GDM. Results Being HBsAg positive was discovered to be an independent risk factor for GDM.Pre-pregnancy Obesity and advanced age were linked to an increased incidence of GDM. Those with a high HBV DNA load (> 106 IU/mL) had a higher risk of GDM than HBsAg-positive women with a low viral load (< 103 IU/mL). Pre-eclampsia and intrahepatic cholestasis of pregnancy (ICP) appeared to be more common in HBsAg-positive women than in uninfected women. Conclusions Being HBsAg positive, advanced age, and pre-pregnancy obesity were all revealed to be independent risk factors for GDM in our study. In HBsAg carrier, pregnant women, a high HBV DNA burden was linked to a greater risk of GDM. Furthermore, being an HBsAg carrier during pregnancy raised the risk of ICP and pre-eclampsia.Wanchang YinBingjun ChenYilin YangXiuzi LiRuirui LiJiangnan XieGuixian ChenFang HeDunjin ChenBMCarticleHepatitis B surface antigenDeoxyribonucleic acid loadGestational diabetes mellitusInfectious and parasitic diseasesRC109-216ENVirology Journal, Vol 18, Iss 1, Pp 1-9 (2021) |
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Hepatitis B surface antigen Deoxyribonucleic acid load Gestational diabetes mellitus Infectious and parasitic diseases RC109-216 |
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Hepatitis B surface antigen Deoxyribonucleic acid load Gestational diabetes mellitus Infectious and parasitic diseases RC109-216 Wanchang Yin Bingjun Chen Yilin Yang Xiuzi Li Ruirui Li Jiangnan Xie Guixian Chen Fang He Dunjin Chen Association between maternal hepatitis B virus carrier and gestational diabetes mellitus: a retrospective cohort analysis |
| description |
Abstract Introduction Given that many pregnant women have chronic hepatitis B virus (HBV) infection and that gestational diabetes mellitus (GDM) is linked to poor maternal and neonatal outcomes, we looked into the relationship between the hepatitis B surface antigen (HBsAg) and GDM to see if a high HBV DNA load is linked to a higher risk of GDM in chronic maternal HBsAg carriers. Materials and methods Our study included 39,539 pregnant women who gave birth at the Third Affiliated Hospital of Guangzhou Medical University in Guangzhou, China, between January 1, 2009, and December 31, 2019. The patients were divided into two groups: HBsAg negative (36,500) and positive (3039). The viral load levels of 1250 HBsAg-positive women who had tested their HBV DNA load during pregnancy were separated into three groups. We utilized univariate and multivariable logistical regression analysis to determine the relationship between maternal chronic HBsAg carrier and GDM. Results Being HBsAg positive was discovered to be an independent risk factor for GDM.Pre-pregnancy Obesity and advanced age were linked to an increased incidence of GDM. Those with a high HBV DNA load (> 106 IU/mL) had a higher risk of GDM than HBsAg-positive women with a low viral load (< 103 IU/mL). Pre-eclampsia and intrahepatic cholestasis of pregnancy (ICP) appeared to be more common in HBsAg-positive women than in uninfected women. Conclusions Being HBsAg positive, advanced age, and pre-pregnancy obesity were all revealed to be independent risk factors for GDM in our study. In HBsAg carrier, pregnant women, a high HBV DNA burden was linked to a greater risk of GDM. Furthermore, being an HBsAg carrier during pregnancy raised the risk of ICP and pre-eclampsia. |
| format |
article |
| author |
Wanchang Yin Bingjun Chen Yilin Yang Xiuzi Li Ruirui Li Jiangnan Xie Guixian Chen Fang He Dunjin Chen |
| author_facet |
Wanchang Yin Bingjun Chen Yilin Yang Xiuzi Li Ruirui Li Jiangnan Xie Guixian Chen Fang He Dunjin Chen |
| author_sort |
Wanchang Yin |
| title |
Association between maternal hepatitis B virus carrier and gestational diabetes mellitus: a retrospective cohort analysis |
| title_short |
Association between maternal hepatitis B virus carrier and gestational diabetes mellitus: a retrospective cohort analysis |
| title_full |
Association between maternal hepatitis B virus carrier and gestational diabetes mellitus: a retrospective cohort analysis |
| title_fullStr |
Association between maternal hepatitis B virus carrier and gestational diabetes mellitus: a retrospective cohort analysis |
| title_full_unstemmed |
Association between maternal hepatitis B virus carrier and gestational diabetes mellitus: a retrospective cohort analysis |
| title_sort |
association between maternal hepatitis b virus carrier and gestational diabetes mellitus: a retrospective cohort analysis |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/030be16c14f44a908433b5dd4770b061 |
| work_keys_str_mv |
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| _version_ |
1718419283210403840 |