Using single nucleotide variations in single-cell RNA-seq to identify subpopulations and genotype-phenotype linkage

Using single nucleotide variations in single-cell RNA-seq to identify subpopulations and genotype-phenotype linkage

Identification of cell subpopulations using transcript abundance is noisy. Here, the authors developed a linear modeling framework, SSrGE, which utilizes effective and expressed nucleotide variations from single-cell RNA-seq to identify tumor subpopulations.

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Detalles Bibliográficos
Autores principales: Olivier Poirion, Xun Zhu, Travers Ching, Lana X. Garmire
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/030c4e53dc1f4d4e929628607a36e0d0
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