Cytokines and depression in cancer patients and caregivers

Madeline Li,1,2 Ekaterina Kouzmina,3 Megan McCusker,1 Danielle Rodin,4 Paul C Boutros,3,5,6 Christopher J Paige,6–8 Gary Rodin1,2 1Princess Margaret Cancer Centre, Department of Supportive Care, University Health Network, Toronto, Ontario, Canada; 2Department of Psychiatry, University of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Li M, Kouzmina E, McCusker M, Rodin D, Boutros PC, Paige CJ, Rodin G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Depression Psychological Symptoms Somatic Symptoms Cytokines Cancer Caregiver Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/030c560ceb414f60bbe3383d767756e8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:030c560ceb414f60bbe3383d767756e8
record_format	dspace
spelling	oai:doaj.org-article:030c560ceb414f60bbe3383d767756e82021-12-02T00:06:00ZCytokines and depression in cancer patients and caregivers1178-2021https://doaj.org/article/030c560ceb414f60bbe3383d767756e82017-11-01T00:00:00Zhttps://www.dovepress.com/cytokines-and-depression-in-cancer-patients-and-caregivers-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Madeline Li,1,2 Ekaterina Kouzmina,3 Megan McCusker,1 Danielle Rodin,4 Paul C Boutros,3,5,6 Christopher J Paige,6–8 Gary Rodin1,2 1Princess Margaret Cancer Centre, Department of Supportive Care, University Health Network, Toronto, Ontario, Canada; 2Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; 3Informatics & Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada; 4Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; 5Department of Pharmacology & Toxicology, Toronto, Ontario, Canada; 6Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 7Department of Immunology, University of Toronto, Toronto, Ontario, Canada; 8Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada Objective: A better understanding of the biobehavioral mechanisms underlying depression in cancer is required to translate biomarker findings into clinical interventions. We tested for associations between cytokines and the somatic and psychological symptoms of depression in cancer patients and their healthy caregivers.Patients and methods: The GRID Hamilton Rating Scale for Depression (Ham-D) was administered to 61 cancer patients of mixed type and stage, 26 primary caregivers and 38 healthy controls. Concurrently, blood was drawn for multiplexed plasma assays of 15 cytokines. Multiple linear regression, adjusted for biobehavioral variables, identified cytokine associations with the psychological (Ham-Dep) and somatic (Ham-Som) subfactors of the Ham-D.Results: The Ham-Dep scores of cancer patients were similar to their caregivers, but their Ham-Som scores were significantly higher (twofold, p=0.016). Ham-Som was positively associated with IL-1ra (coefficient: 1.27, p≤0.001) in cancer patients, and negatively associated with IL-2 (coefficient: -0.68, p=0.018) in caregivers. Ham-Dep was negatively associated with IL-4 (coefficient: -0.67, p=0.004) in cancer patients and negatively associated with IL-17 (coefficient: -1.81, p=0.002) in caregivers.Conclusion: The differential severity of somatic symptoms of depression in cancer patients and caregivers and the unique cytokine associations identified with each group suggests the potential for targeted interventions based on phenomenology and biology. The clinical implication is that depressive symptoms in cancer patients can arise from biological stressors, which is an important message to help destigmatize the development of depression in cancer patients. Keywords: depression, psychological symptoms, somatic symptoms, cytokines, cancer, caregiverLi MKouzmina EMcCusker MRodin DBoutros PCPaige CJRodin GDove Medical PressarticleDepressionPsychological SymptomsSomatic SymptomsCytokinesCancerCaregiverNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2903-2911 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Depression Psychological Symptoms Somatic Symptoms Cytokines Cancer Caregiver Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Depression Psychological Symptoms Somatic Symptoms Cytokines Cancer Caregiver Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li M Kouzmina E McCusker M Rodin D Boutros PC Paige CJ Rodin G Cytokines and depression in cancer patients and caregivers
description	Madeline Li,1,2 Ekaterina Kouzmina,3 Megan McCusker,1 Danielle Rodin,4 Paul C Boutros,3,5,6 Christopher J Paige,6–8 Gary Rodin1,2 1Princess Margaret Cancer Centre, Department of Supportive Care, University Health Network, Toronto, Ontario, Canada; 2Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; 3Informatics & Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada; 4Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; 5Department of Pharmacology & Toxicology, Toronto, Ontario, Canada; 6Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 7Department of Immunology, University of Toronto, Toronto, Ontario, Canada; 8Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada Objective: A better understanding of the biobehavioral mechanisms underlying depression in cancer is required to translate biomarker findings into clinical interventions. We tested for associations between cytokines and the somatic and psychological symptoms of depression in cancer patients and their healthy caregivers.Patients and methods: The GRID Hamilton Rating Scale for Depression (Ham-D) was administered to 61 cancer patients of mixed type and stage, 26 primary caregivers and 38 healthy controls. Concurrently, blood was drawn for multiplexed plasma assays of 15 cytokines. Multiple linear regression, adjusted for biobehavioral variables, identified cytokine associations with the psychological (Ham-Dep) and somatic (Ham-Som) subfactors of the Ham-D.Results: The Ham-Dep scores of cancer patients were similar to their caregivers, but their Ham-Som scores were significantly higher (twofold, p=0.016). Ham-Som was positively associated with IL-1ra (coefficient: 1.27, p≤0.001) in cancer patients, and negatively associated with IL-2 (coefficient: -0.68, p=0.018) in caregivers. Ham-Dep was negatively associated with IL-4 (coefficient: -0.67, p=0.004) in cancer patients and negatively associated with IL-17 (coefficient: -1.81, p=0.002) in caregivers.Conclusion: The differential severity of somatic symptoms of depression in cancer patients and caregivers and the unique cytokine associations identified with each group suggests the potential for targeted interventions based on phenomenology and biology. The clinical implication is that depressive symptoms in cancer patients can arise from biological stressors, which is an important message to help destigmatize the development of depression in cancer patients. Keywords: depression, psychological symptoms, somatic symptoms, cytokines, cancer, caregiver
format	article
author	Li M Kouzmina E McCusker M Rodin D Boutros PC Paige CJ Rodin G
author_facet	Li M Kouzmina E McCusker M Rodin D Boutros PC Paige CJ Rodin G
author_sort	Li M
title	Cytokines and depression in cancer patients and caregivers
title_short	Cytokines and depression in cancer patients and caregivers
title_full	Cytokines and depression in cancer patients and caregivers
title_fullStr	Cytokines and depression in cancer patients and caregivers
title_full_unstemmed	Cytokines and depression in cancer patients and caregivers
title_sort	cytokines and depression in cancer patients and caregivers
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/030c560ceb414f60bbe3383d767756e8
work_keys_str_mv	AT lim cytokinesanddepressionincancerpatientsandcaregivers AT kouzminae cytokinesanddepressionincancerpatientsandcaregivers AT mccuskerm cytokinesanddepressionincancerpatientsandcaregivers AT rodind cytokinesanddepressionincancerpatientsandcaregivers AT boutrospc cytokinesanddepressionincancerpatientsandcaregivers AT paigecj cytokinesanddepressionincancerpatientsandcaregivers AT roding cytokinesanddepressionincancerpatientsandcaregivers
_version_	1718403904206536704

Cytokines and depression in cancer patients and caregivers

Ejemplares similares