Blood Plasma Proteins Associated With Heart Rate Variability in Cosmonauts Who Have Completed Long-Duration Space Missions

The study presents the results of evaluating the changes in the concentrations of blood plasma proteins associated with heart rate variability (HRV) in cosmonauts who have completed space missions lasting about 6months. The concentrations of 125 proteins were quantified in biological samples of the...

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Autores principales:	Ludmila Kh. Pastushkova, Vasily B. Rusanov, Anna G. Goncharova, Andrei M. Nosovskiy, Elena S. Luchitskaya, Daria N. Kashirina, Alexey S. Kononikhin, Anna R. Kussmaul, Yusef D. Yakhya, Irina M. Larina, Evgeny N. Nikolaev
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cosmonauts long-duration space missions blood proteome heart rate variability sympathetic and parasympathetic regulation Physiology QP1-981
Acceso en línea:	https://doaj.org/article/030ce10721a24e0db15ebca94a93b42f
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spelling	oai:doaj.org-article:030ce10721a24e0db15ebca94a93b42f2021-11-17T07:02:40ZBlood Plasma Proteins Associated With Heart Rate Variability in Cosmonauts Who Have Completed Long-Duration Space Missions1664-042X10.3389/fphys.2021.760875https://doaj.org/article/030ce10721a24e0db15ebca94a93b42f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.760875/fullhttps://doaj.org/toc/1664-042XThe study presents the results of evaluating the changes in the concentrations of blood plasma proteins associated with heart rate variability (HRV) in cosmonauts who have completed space missions lasting about 6months. The concentrations of 125 proteins were quantified in biological samples of the cosmonauts’ blood plasma. The subgroups of proteins associated with the physiological processes of the HRV autonomic regulation were identified using bioinformatic resources (Immunoglobulin heavy constant mu, Complement C1q subcomponent subunit C, Plasma serine protease inhibitor, Protein-72kDa type IV collagenase, Fibulin-1, Immunoglobulin lambda constant 3). The concentration of these proteins in the blood plasma before the flight, and the dynamics of concentration changes on the 1st and 7th days of the post-flight rehabilitation period differed in the groups of cosmonauts with a predominance of sympathetic or parasympathetic modulating autonomous influences. The dynamics of changes in the concentrations of the identified set of proteins reveal that in cosmonauts with a predominance of sympathetic modulating influences, the mechanisms of autonomic regulation are exposed to significant stress in the recovery period immediately after the completion of the space mission, compared with the cosmonauts with a predominance of parasympathetic modulating influences.Ludmila Kh. PastushkovaVasily B. RusanovAnna G. GoncharovaAndrei M. NosovskiyElena S. LuchitskayaDaria N. KashirinaAlexey S. KononikhinAlexey S. KononikhinAnna R. KussmaulYusef D. YakhyaIrina M. LarinaEvgeny N. NikolaevFrontiers Media S.A.articlecosmonautslong-duration space missionsblood proteomeheart rate variabilitysympathetic andparasympathetic regulationPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cosmonauts long-duration space missions blood proteome heart rate variability sympathetic and parasympathetic regulation Physiology QP1-981
spellingShingle	cosmonauts long-duration space missions blood proteome heart rate variability sympathetic and parasympathetic regulation Physiology QP1-981 Ludmila Kh. Pastushkova Vasily B. Rusanov Anna G. Goncharova Andrei M. Nosovskiy Elena S. Luchitskaya Daria N. Kashirina Alexey S. Kononikhin Alexey S. Kononikhin Anna R. Kussmaul Yusef D. Yakhya Irina M. Larina Evgeny N. Nikolaev Blood Plasma Proteins Associated With Heart Rate Variability in Cosmonauts Who Have Completed Long-Duration Space Missions
description	The study presents the results of evaluating the changes in the concentrations of blood plasma proteins associated with heart rate variability (HRV) in cosmonauts who have completed space missions lasting about 6months. The concentrations of 125 proteins were quantified in biological samples of the cosmonauts’ blood plasma. The subgroups of proteins associated with the physiological processes of the HRV autonomic regulation were identified using bioinformatic resources (Immunoglobulin heavy constant mu, Complement C1q subcomponent subunit C, Plasma serine protease inhibitor, Protein-72kDa type IV collagenase, Fibulin-1, Immunoglobulin lambda constant 3). The concentration of these proteins in the blood plasma before the flight, and the dynamics of concentration changes on the 1st and 7th days of the post-flight rehabilitation period differed in the groups of cosmonauts with a predominance of sympathetic or parasympathetic modulating autonomous influences. The dynamics of changes in the concentrations of the identified set of proteins reveal that in cosmonauts with a predominance of sympathetic modulating influences, the mechanisms of autonomic regulation are exposed to significant stress in the recovery period immediately after the completion of the space mission, compared with the cosmonauts with a predominance of parasympathetic modulating influences.
format	article
author	Ludmila Kh. Pastushkova Vasily B. Rusanov Anna G. Goncharova Andrei M. Nosovskiy Elena S. Luchitskaya Daria N. Kashirina Alexey S. Kononikhin Alexey S. Kononikhin Anna R. Kussmaul Yusef D. Yakhya Irina M. Larina Evgeny N. Nikolaev
author_facet	Ludmila Kh. Pastushkova Vasily B. Rusanov Anna G. Goncharova Andrei M. Nosovskiy Elena S. Luchitskaya Daria N. Kashirina Alexey S. Kononikhin Alexey S. Kononikhin Anna R. Kussmaul Yusef D. Yakhya Irina M. Larina Evgeny N. Nikolaev
author_sort	Ludmila Kh. Pastushkova
title	Blood Plasma Proteins Associated With Heart Rate Variability in Cosmonauts Who Have Completed Long-Duration Space Missions
title_short	Blood Plasma Proteins Associated With Heart Rate Variability in Cosmonauts Who Have Completed Long-Duration Space Missions
title_full	Blood Plasma Proteins Associated With Heart Rate Variability in Cosmonauts Who Have Completed Long-Duration Space Missions
title_fullStr	Blood Plasma Proteins Associated With Heart Rate Variability in Cosmonauts Who Have Completed Long-Duration Space Missions
title_full_unstemmed	Blood Plasma Proteins Associated With Heart Rate Variability in Cosmonauts Who Have Completed Long-Duration Space Missions
title_sort	blood plasma proteins associated with heart rate variability in cosmonauts who have completed long-duration space missions
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/030ce10721a24e0db15ebca94a93b42f
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Blood Plasma Proteins Associated With Heart Rate Variability in Cosmonauts Who Have Completed Long-Duration Space Missions

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