Biomimetic Growth of Hydroxyapatite on SiO<sub>2</sub> Microspheres to Improve Its Biocompatibility and Gentamicin Loading Capacity

The interest in multifunctional biomaterials to be implanted are also able to release drugs that reduce pain and inflammation or prevent a possible infection has increased. Bioactive materials such as silica (SiO<sub>2</sub>) containing surface silanol groups contribute to the nucleation...

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Autores principales:	Alejandra E. Herrera-Alonso, María C. Ibarra-Alonso, Sandra C. Esparza-González, Sofía Estrada-Flores, Luis A. García-Cerda, Antonia Martínez-Luévanos
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biocompatibility biomimetic growth gentamicin drug load hydroxyapatite silica Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/030e93abfad64e4294840d5086ba29c1
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spelling	oai:doaj.org-article:030e93abfad64e4294840d5086ba29c12021-11-25T18:14:54ZBiomimetic Growth of Hydroxyapatite on SiO<sub>2</sub> Microspheres to Improve Its Biocompatibility and Gentamicin Loading Capacity10.3390/ma142269411996-1944https://doaj.org/article/030e93abfad64e4294840d5086ba29c12021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/22/6941https://doaj.org/toc/1996-1944The interest in multifunctional biomaterials to be implanted are also able to release drugs that reduce pain and inflammation or prevent a possible infection has increased. Bioactive materials such as silica (SiO<sub>2</sub>) containing surface silanol groups contribute to the nucleation and growth of hydroxyapatite (HAp) in a physiological environment. Regarding biocompatibility, the spherical shape of particles is the desirable one, since it does not cause mechanical damage to the cell membrane. In this work, the synthesis of SiO<sub>2</sub> microspheres was performed by the modified Stöber method and they were used for the biomimetic growth of HAp on their surface. The effect of the type of surfactant (sodium dodecyl sulphate (SDS), cetyltrimethylammonium bromide (CTAB), and polyethylene glycol (PEG)), and heat treatment on the morphology and size of SiO<sub>2</sub> particles was investigated. Monodisperse, spherical-shaped SiO<sub>2</sub> microparticles with an average particle size of 179 nm, were obtained when using PEG (SiO<sub>2</sub>-PEG). The biomimetic growth of HAp was performed on this sample to improve its biocompatibility and drug-loading capacity using gentamicin as a model drug. Biomimetic growth of HAp was confirmed by FTIR-ATR, SEM-EDX and TEM techniques. SiO<sub>2</sub>-PEG/HAp sample had a better biocompatibility in vitro and gentamicin loading capacity than SiO<sub>2</sub>-PEG sample.Alejandra E. Herrera-AlonsoMaría C. Ibarra-AlonsoSandra C. Esparza-GonzálezSofía Estrada-FloresLuis A. García-CerdaAntonia Martínez-LuévanosMDPI AGarticlebiocompatibilitybiomimetic growthgentamicindrug loadhydroxyapatitesilicaTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6941, p 6941 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biocompatibility biomimetic growth gentamicin drug load hydroxyapatite silica Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	biocompatibility biomimetic growth gentamicin drug load hydroxyapatite silica Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Alejandra E. Herrera-Alonso María C. Ibarra-Alonso Sandra C. Esparza-González Sofía Estrada-Flores Luis A. García-Cerda Antonia Martínez-Luévanos Biomimetic Growth of Hydroxyapatite on SiO<sub>2</sub> Microspheres to Improve Its Biocompatibility and Gentamicin Loading Capacity
description	The interest in multifunctional biomaterials to be implanted are also able to release drugs that reduce pain and inflammation or prevent a possible infection has increased. Bioactive materials such as silica (SiO<sub>2</sub>) containing surface silanol groups contribute to the nucleation and growth of hydroxyapatite (HAp) in a physiological environment. Regarding biocompatibility, the spherical shape of particles is the desirable one, since it does not cause mechanical damage to the cell membrane. In this work, the synthesis of SiO<sub>2</sub> microspheres was performed by the modified Stöber method and they were used for the biomimetic growth of HAp on their surface. The effect of the type of surfactant (sodium dodecyl sulphate (SDS), cetyltrimethylammonium bromide (CTAB), and polyethylene glycol (PEG)), and heat treatment on the morphology and size of SiO<sub>2</sub> particles was investigated. Monodisperse, spherical-shaped SiO<sub>2</sub> microparticles with an average particle size of 179 nm, were obtained when using PEG (SiO<sub>2</sub>-PEG). The biomimetic growth of HAp was performed on this sample to improve its biocompatibility and drug-loading capacity using gentamicin as a model drug. Biomimetic growth of HAp was confirmed by FTIR-ATR, SEM-EDX and TEM techniques. SiO<sub>2</sub>-PEG/HAp sample had a better biocompatibility in vitro and gentamicin loading capacity than SiO<sub>2</sub>-PEG sample.
format	article
author	Alejandra E. Herrera-Alonso María C. Ibarra-Alonso Sandra C. Esparza-González Sofía Estrada-Flores Luis A. García-Cerda Antonia Martínez-Luévanos
author_facet	Alejandra E. Herrera-Alonso María C. Ibarra-Alonso Sandra C. Esparza-González Sofía Estrada-Flores Luis A. García-Cerda Antonia Martínez-Luévanos
author_sort	Alejandra E. Herrera-Alonso
title	Biomimetic Growth of Hydroxyapatite on SiO<sub>2</sub> Microspheres to Improve Its Biocompatibility and Gentamicin Loading Capacity
title_short	Biomimetic Growth of Hydroxyapatite on SiO<sub>2</sub> Microspheres to Improve Its Biocompatibility and Gentamicin Loading Capacity
title_full	Biomimetic Growth of Hydroxyapatite on SiO<sub>2</sub> Microspheres to Improve Its Biocompatibility and Gentamicin Loading Capacity
title_fullStr	Biomimetic Growth of Hydroxyapatite on SiO<sub>2</sub> Microspheres to Improve Its Biocompatibility and Gentamicin Loading Capacity
title_full_unstemmed	Biomimetic Growth of Hydroxyapatite on SiO<sub>2</sub> Microspheres to Improve Its Biocompatibility and Gentamicin Loading Capacity
title_sort	biomimetic growth of hydroxyapatite on sio<sub>2</sub> microspheres to improve its biocompatibility and gentamicin loading capacity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/030e93abfad64e4294840d5086ba29c1
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Biomimetic Growth of Hydroxyapatite on SiO<sub>2</sub> Microspheres to Improve Its Biocompatibility and Gentamicin Loading Capacity

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