DETERMINATION OF REFERENCE INTERVAL OF LIVER FUNCTION TESTS DURING PREGNANCY IN URBAN AREA OF DISTRICT RAWALPINDI PAKISTAN

Objective: To determine the reference Interval of liver function tests during uncomplicated pregnancy in population of Rawalpindi and assess their correlation over first and second trimesters of pregnancy. Study Design: Cross sectional study. Place and Duration of Study: Department of Chemical Patho...

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Autores principales:	Alveena Younas, Mehwish Gilani, Qurat ul ain, Naveed Asif, Muhammad Aamir, Asif Ali
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	liver function tests pregnancy reference interval Medicine R Medicine (General) R5-920
Acceso en línea:	https://doi.org/10.51253/pafmj.v71iSuppl-1.2404 https://doaj.org/article/030f80c8ae5d4f449358149ff7fbb8a4
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spelling	oai:doaj.org-article:030f80c8ae5d4f449358149ff7fbb8a42021-12-02T19:11:54ZDETERMINATION OF REFERENCE INTERVAL OF LIVER FUNCTION TESTS DURING PREGNANCY IN URBAN AREA OF DISTRICT RAWALPINDI PAKISTANhttps://doi.org/10.51253/pafmj.v71iSuppl-1.24040030-96482411-8842https://doaj.org/article/030f80c8ae5d4f449358149ff7fbb8a42021-01-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/2404https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the reference Interval of liver function tests during uncomplicated pregnancy in population of Rawalpindi and assess their correlation over first and second trimesters of pregnancy. Study Design: Cross sectional study. Place and Duration of Study: Department of Chemical Pathology & Endocrinology Armed Forces Institute of Pathology Rawalpindi from Feb 2017 to Jun 2018. Methodology: Seven hundred and fifty four pregnant women with uncomplicated, single intrauterine pregnancy were recruited from Rawalpindi. Thirteen patients with known history of Diabetes Mellitus, hypertension, liver disease, renal disorders and those on anti-epileptics, non-steroidal anti-inflammatory drugs and steroids were excluded from the study. Blood sample was taken from each subject to analyze serum bilirubin, albumin, total al-kaline phosphates and alanine aminotransferase on random access discrete auto analyser, ADVIA 1800 Chemistry system manufactured in Japan for Siemens Healthcare Diagnostics Inc. Data for serum bilirubin, albumin, ALP and ALT were expressed as mean ± standard deviation. As the reference data followed the Gaussian distribu-tion, therefore the 2.5th and 97.5th percentiles were estimated by values approximately 2SD on each side of mean. Results: After analysis of serum samples of 754 subjects, the reference intervals for bilirubin, albumin, ALP and ALT during first trimester were; bilirubin 3-9 μmol/l, albumin 31-45 g/L, ALP 122-224 U/l and ALT 3-35 U/l, while of second trimester were: bilirubin 2- 7μmol/l, albumin 28-45 g/L, ALP131-300U/l and ALT 1-33U/l. Conclusion: First and second trimester wise reference values of Liver Function Tests have been determined in pregnancy in this study. This would not only help in monitoring of normal biochemical changes of pregnancy but will also lead to prompt detection of fatal pregnancy complications.Alveena YounasMehwish GilaniQurat ul ainNaveed AsifMuhammad AamirAsif AliArmy Medical College Rawalpindiarticleliver function testspregnancyreference intervalMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss SUPPL-1, Pp 250-254 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	liver function tests pregnancy reference interval Medicine R Medicine (General) R5-920
spellingShingle	liver function tests pregnancy reference interval Medicine R Medicine (General) R5-920 Alveena Younas Mehwish Gilani Qurat ul ain Naveed Asif Muhammad Aamir Asif Ali DETERMINATION OF REFERENCE INTERVAL OF LIVER FUNCTION TESTS DURING PREGNANCY IN URBAN AREA OF DISTRICT RAWALPINDI PAKISTAN
description	Objective: To determine the reference Interval of liver function tests during uncomplicated pregnancy in population of Rawalpindi and assess their correlation over first and second trimesters of pregnancy. Study Design: Cross sectional study. Place and Duration of Study: Department of Chemical Pathology & Endocrinology Armed Forces Institute of Pathology Rawalpindi from Feb 2017 to Jun 2018. Methodology: Seven hundred and fifty four pregnant women with uncomplicated, single intrauterine pregnancy were recruited from Rawalpindi. Thirteen patients with known history of Diabetes Mellitus, hypertension, liver disease, renal disorders and those on anti-epileptics, non-steroidal anti-inflammatory drugs and steroids were excluded from the study. Blood sample was taken from each subject to analyze serum bilirubin, albumin, total al-kaline phosphates and alanine aminotransferase on random access discrete auto analyser, ADVIA 1800 Chemistry system manufactured in Japan for Siemens Healthcare Diagnostics Inc. Data for serum bilirubin, albumin, ALP and ALT were expressed as mean ± standard deviation. As the reference data followed the Gaussian distribu-tion, therefore the 2.5th and 97.5th percentiles were estimated by values approximately 2SD on each side of mean. Results: After analysis of serum samples of 754 subjects, the reference intervals for bilirubin, albumin, ALP and ALT during first trimester were; bilirubin 3-9 μmol/l, albumin 31-45 g/L, ALP 122-224 U/l and ALT 3-35 U/l, while of second trimester were: bilirubin 2- 7μmol/l, albumin 28-45 g/L, ALP131-300U/l and ALT 1-33U/l. Conclusion: First and second trimester wise reference values of Liver Function Tests have been determined in pregnancy in this study. This would not only help in monitoring of normal biochemical changes of pregnancy but will also lead to prompt detection of fatal pregnancy complications.
format	article
author	Alveena Younas Mehwish Gilani Qurat ul ain Naveed Asif Muhammad Aamir Asif Ali
author_facet	Alveena Younas Mehwish Gilani Qurat ul ain Naveed Asif Muhammad Aamir Asif Ali
author_sort	Alveena Younas
title	DETERMINATION OF REFERENCE INTERVAL OF LIVER FUNCTION TESTS DURING PREGNANCY IN URBAN AREA OF DISTRICT RAWALPINDI PAKISTAN
title_short	DETERMINATION OF REFERENCE INTERVAL OF LIVER FUNCTION TESTS DURING PREGNANCY IN URBAN AREA OF DISTRICT RAWALPINDI PAKISTAN
title_full	DETERMINATION OF REFERENCE INTERVAL OF LIVER FUNCTION TESTS DURING PREGNANCY IN URBAN AREA OF DISTRICT RAWALPINDI PAKISTAN
title_fullStr	DETERMINATION OF REFERENCE INTERVAL OF LIVER FUNCTION TESTS DURING PREGNANCY IN URBAN AREA OF DISTRICT RAWALPINDI PAKISTAN
title_full_unstemmed	DETERMINATION OF REFERENCE INTERVAL OF LIVER FUNCTION TESTS DURING PREGNANCY IN URBAN AREA OF DISTRICT RAWALPINDI PAKISTAN
title_sort	determination of reference interval of liver function tests during pregnancy in urban area of district rawalpindi pakistan
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doi.org/10.51253/pafmj.v71iSuppl-1.2404 https://doaj.org/article/030f80c8ae5d4f449358149ff7fbb8a4
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DETERMINATION OF REFERENCE INTERVAL OF LIVER FUNCTION TESTS DURING PREGNANCY IN URBAN AREA OF DISTRICT RAWALPINDI PAKISTAN

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