DNA Methylation Profiling of MYC, SMAD2/3 and DNMT3A in Colorectal Cancer

Epigenetic modifications, particularly DNA methylation, is commonplace and a remarkable factor in carcinogenesis transformation. Conspicuously, previous findings have presented a cluster of irregular promoter methylation alterations related with silencing of tumor suppressor genes, little is accepte...

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Autores principales:	Seyedeh Elham Norollahi, Maryam Gholamniya Foumani, Maryam Khoshbakht Pishkhan, Afshin Shafaghi, Majid Alipour, Vida Baloui Jamkhaneh, Mohammad Namayan Marghoob, Sogand Vahidi
Formato:	article
Lenguaje:	EN
Publicado:	Oman Medical Specialty Board 2021
Materias:	dna methylation colorectal neoplasms genes tumor suppressor genomic instability Medicine R
Acceso en línea:	https://doaj.org/article/031137933ddf4c74928f3f5dddf89896
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spelling	oai:doaj.org-article:031137933ddf4c74928f3f5dddf898962021-11-10T10:45:49ZDNA Methylation Profiling of MYC, SMAD2/3 and DNMT3A in Colorectal Cancer10.5001/omj.2020.931999-768X2070-5204https://doaj.org/article/031137933ddf4c74928f3f5dddf898962021-11-01T00:00:00Zhttps://omjournal.org/articleDetails.aspx?coType=1&aId=3012https://doaj.org/toc/1999-768Xhttps://doaj.org/toc/2070-5204Epigenetic modifications, particularly DNA methylation, is commonplace and a remarkable factor in carcinogenesis transformation. Conspicuously, previous findings have presented a cluster of irregular promoter methylation alterations related with silencing of tumor suppressor genes, little is accepted regarding their sequential DNA methylation (hypo and hyper) modifications during the cancer progression. In this way, fluctuations of DNA methylation of many genes, especially MYC, SMAD2/3, and DNMT3A, have an impressive central key role in many different cancers, including colorectal cancer (CRC). CRC is distinguished by DNA methylation, which is related to tumorigenesis and also genomic instability. Importantly, molecular heterogeneity between multiple adenomas in different patients with CRC may show diverse developmental phenotypes for these kinds of tumors. Conclusively, studying factors that are involved in CRC carcinogenesis, especially the alterations in epigenetic elements, such as DNA methylation besides RNA remodeling, and histone modification, acetylation and phosphorylation, can be influential to find new therapeutic and diagnostic biomarkers in this type of malignancy. In this account, we discuss and address the potential significant methylated modifications of these genes and their importance during the development of CRC carcinogenesis. Seyedeh Elham NorollahiMaryam Gholamniya FoumaniMaryam Khoshbakht PishkhanAfshin ShafaghiMajid AlipourVida Baloui JamkhanehMohammad Namayan MarghoobSogand VahidiOman Medical Specialty Boardarticledna methylationcolorectal neoplasmsgenestumor suppressorgenomic instabilityMedicineRENOman Medical Journal, Vol 36, Iss 6, Pp e315-e315 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dna methylation colorectal neoplasms genes tumor suppressor genomic instability Medicine R
spellingShingle	dna methylation colorectal neoplasms genes tumor suppressor genomic instability Medicine R Seyedeh Elham Norollahi Maryam Gholamniya Foumani Maryam Khoshbakht Pishkhan Afshin Shafaghi Majid Alipour Vida Baloui Jamkhaneh Mohammad Namayan Marghoob Sogand Vahidi DNA Methylation Profiling of MYC, SMAD2/3 and DNMT3A in Colorectal Cancer
description	Epigenetic modifications, particularly DNA methylation, is commonplace and a remarkable factor in carcinogenesis transformation. Conspicuously, previous findings have presented a cluster of irregular promoter methylation alterations related with silencing of tumor suppressor genes, little is accepted regarding their sequential DNA methylation (hypo and hyper) modifications during the cancer progression. In this way, fluctuations of DNA methylation of many genes, especially MYC, SMAD2/3, and DNMT3A, have an impressive central key role in many different cancers, including colorectal cancer (CRC). CRC is distinguished by DNA methylation, which is related to tumorigenesis and also genomic instability. Importantly, molecular heterogeneity between multiple adenomas in different patients with CRC may show diverse developmental phenotypes for these kinds of tumors. Conclusively, studying factors that are involved in CRC carcinogenesis, especially the alterations in epigenetic elements, such as DNA methylation besides RNA remodeling, and histone modification, acetylation and phosphorylation, can be influential to find new therapeutic and diagnostic biomarkers in this type of malignancy. In this account, we discuss and address the potential significant methylated modifications of these genes and their importance during the development of CRC carcinogenesis.
format	article
author	Seyedeh Elham Norollahi Maryam Gholamniya Foumani Maryam Khoshbakht Pishkhan Afshin Shafaghi Majid Alipour Vida Baloui Jamkhaneh Mohammad Namayan Marghoob Sogand Vahidi
author_facet	Seyedeh Elham Norollahi Maryam Gholamniya Foumani Maryam Khoshbakht Pishkhan Afshin Shafaghi Majid Alipour Vida Baloui Jamkhaneh Mohammad Namayan Marghoob Sogand Vahidi
author_sort	Seyedeh Elham Norollahi
title	DNA Methylation Profiling of MYC, SMAD2/3 and DNMT3A in Colorectal Cancer
title_short	DNA Methylation Profiling of MYC, SMAD2/3 and DNMT3A in Colorectal Cancer
title_full	DNA Methylation Profiling of MYC, SMAD2/3 and DNMT3A in Colorectal Cancer
title_fullStr	DNA Methylation Profiling of MYC, SMAD2/3 and DNMT3A in Colorectal Cancer
title_full_unstemmed	DNA Methylation Profiling of MYC, SMAD2/3 and DNMT3A in Colorectal Cancer
title_sort	dna methylation profiling of myc, smad2/3 and dnmt3a in colorectal cancer
publisher	Oman Medical Specialty Board
publishDate	2021
url	https://doaj.org/article/031137933ddf4c74928f3f5dddf89896
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DNA Methylation Profiling of MYC, SMAD2/3 and DNMT3A in Colorectal Cancer

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