Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain

Abstract Accumulation of metabolic wastes in the brain is correlated with several neurodegenerative disorders, including Alzheimer’s disease. Waste transport and clearance occur via dispersion, the combined effect of diffusion and advection by flow of fluid. We examine the relative contributions of...

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Autores principales:	Daniel E. Troyetsky, Jeffrey Tithof, John H. Thomas, Douglas H. Kelley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0313ce98c27640ceb8a913cd2daae2e4
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spelling	oai:doaj.org-article:0313ce98c27640ceb8a913cd2daae2e42021-12-02T13:19:29ZDispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain10.1038/s41598-021-83951-12045-2322https://doaj.org/article/0313ce98c27640ceb8a913cd2daae2e42021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83951-1https://doaj.org/toc/2045-2322Abstract Accumulation of metabolic wastes in the brain is correlated with several neurodegenerative disorders, including Alzheimer’s disease. Waste transport and clearance occur via dispersion, the combined effect of diffusion and advection by flow of fluid. We examine the relative contributions of diffusion and advection in the perivascular spaces (PVSs) that surround penetrating cortical blood vessels and are filled with cerebrospinal fluid (CSF). To do so, we adapt prior analytic predictions of dispersion to the context of PVSs. We also perform advection-diffusion simulations in PVS-like geometries with parameters relevant to transport of amyloid- $$\beta$$ β (associated with Alzheimer’s) in a variety of flows, motivated by in vivo measurements. Specifically, we examine solute transport in steady and unsteady Poiseuille flows in an open (not porous) concentric circular annulus. We find that a purely oscillatory flow enhances dispersion only weakly and does not produce significant transport, whereas a steady flow component, even if slow, clears waste more effectively.Daniel E. TroyetskyJeffrey TithofJohn H. ThomasDouglas H. KelleyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel E. Troyetsky Jeffrey Tithof John H. Thomas Douglas H. Kelley Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain
description	Abstract Accumulation of metabolic wastes in the brain is correlated with several neurodegenerative disorders, including Alzheimer’s disease. Waste transport and clearance occur via dispersion, the combined effect of diffusion and advection by flow of fluid. We examine the relative contributions of diffusion and advection in the perivascular spaces (PVSs) that surround penetrating cortical blood vessels and are filled with cerebrospinal fluid (CSF). To do so, we adapt prior analytic predictions of dispersion to the context of PVSs. We also perform advection-diffusion simulations in PVS-like geometries with parameters relevant to transport of amyloid- $$\beta$$ β (associated with Alzheimer’s) in a variety of flows, motivated by in vivo measurements. Specifically, we examine solute transport in steady and unsteady Poiseuille flows in an open (not porous) concentric circular annulus. We find that a purely oscillatory flow enhances dispersion only weakly and does not produce significant transport, whereas a steady flow component, even if slow, clears waste more effectively.
format	article
author	Daniel E. Troyetsky Jeffrey Tithof John H. Thomas Douglas H. Kelley
author_facet	Daniel E. Troyetsky Jeffrey Tithof John H. Thomas Douglas H. Kelley
author_sort	Daniel E. Troyetsky
title	Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain
title_short	Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain
title_full	Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain
title_fullStr	Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain
title_full_unstemmed	Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain
title_sort	dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0313ce98c27640ceb8a913cd2daae2e4
work_keys_str_mv	AT danieletroyetsky dispersionasawasteclearancemechanisminflowthroughpenetratingperivascularspacesinthebrain AT jeffreytithof dispersionasawasteclearancemechanisminflowthroughpenetratingperivascularspacesinthebrain AT johnhthomas dispersionasawasteclearancemechanisminflowthroughpenetratingperivascularspacesinthebrain AT douglashkelley dispersionasawasteclearancemechanisminflowthroughpenetratingperivascularspacesinthebrain
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Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain

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