Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas

Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas

It is known that invasive lung adenocarcinomas evolve from pre-cancerous dysplastic lesions. In this study, the authors show that evolution of pre-cancerous lesions is accompanied by DNA methylation alterations, and that global hypomethylation correlates with immune infiltration, mutational burden a...

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Autores principales: Xin Hu, Marcos R. Estecio, Runzhe Chen, Alexandre Reuben, Linghua Wang, Junya Fujimoto, Jian Carrot-Zhang, Nicholas McGranahan, Lisha Ying, Junya Fukuoka, Chi-Wan Chow, Hoa H. N. Pham, Myrna C. B. Godoy, Brett W. Carter, Carmen Behrens, Jianhua Zhang, Mara B. Antonoff, Boris Sepesi, Yue Lu, Harvey I. Pass, Humam Kadara, Paul Scheet, Ara A. Vaporciyan, John V. Heymach, Ignacio I. Wistuba, J. Jack Lee, P. Andrew Futreal, Dan Su, Jean-Pierre J. Issa, Jianjun Zhang
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/031719f1a9f8488a91a5917acd62743f
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spelling oai:doaj.org-article:031719f1a9f8488a91a5917acd62743f2021-12-02T13:57:53ZEvolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas10.1038/s41467-021-20907-z2041-1723https://doaj.org/article/031719f1a9f8488a91a5917acd62743f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20907-zhttps://doaj.org/toc/2041-1723It is known that invasive lung adenocarcinomas evolve from pre-cancerous dysplastic lesions. In this study, the authors show that evolution of pre-cancerous lesions is accompanied by DNA methylation alterations, and that global hypomethylation correlates with immune infiltration, mutational burden and copy number alterations.Xin HuMarcos R. EstecioRunzhe ChenAlexandre ReubenLinghua WangJunya FujimotoJian Carrot-ZhangNicholas McGranahanLisha YingJunya FukuokaChi-Wan ChowHoa H. N. PhamMyrna C. B. GodoyBrett W. CarterCarmen BehrensJianhua ZhangMara B. AntonoffBoris SepesiYue LuHarvey I. PassHumam KadaraPaul ScheetAra A. VaporciyanJohn V. HeymachIgnacio I. WistubaJ. Jack LeeP. Andrew FutrealDan SuJean-Pierre J. IssaJianjun ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xin Hu
Marcos R. Estecio
Runzhe Chen
Alexandre Reuben
Linghua Wang
Junya Fujimoto
Jian Carrot-Zhang
Nicholas McGranahan
Lisha Ying
Junya Fukuoka
Chi-Wan Chow
Hoa H. N. Pham
Myrna C. B. Godoy
Brett W. Carter
Carmen Behrens
Jianhua Zhang
Mara B. Antonoff
Boris Sepesi
Yue Lu
Harvey I. Pass
Humam Kadara
Paul Scheet
Ara A. Vaporciyan
John V. Heymach
Ignacio I. Wistuba
J. Jack Lee
P. Andrew Futreal
Dan Su
Jean-Pierre J. Issa
Jianjun Zhang
Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas
description It is known that invasive lung adenocarcinomas evolve from pre-cancerous dysplastic lesions. In this study, the authors show that evolution of pre-cancerous lesions is accompanied by DNA methylation alterations, and that global hypomethylation correlates with immune infiltration, mutational burden and copy number alterations.
format article
author Xin Hu
Marcos R. Estecio
Runzhe Chen
Alexandre Reuben
Linghua Wang
Junya Fujimoto
Jian Carrot-Zhang
Nicholas McGranahan
Lisha Ying
Junya Fukuoka
Chi-Wan Chow
Hoa H. N. Pham
Myrna C. B. Godoy
Brett W. Carter
Carmen Behrens
Jianhua Zhang
Mara B. Antonoff
Boris Sepesi
Yue Lu
Harvey I. Pass
Humam Kadara
Paul Scheet
Ara A. Vaporciyan
John V. Heymach
Ignacio I. Wistuba
J. Jack Lee
P. Andrew Futreal
Dan Su
Jean-Pierre J. Issa
Jianjun Zhang
author_facet Xin Hu
Marcos R. Estecio
Runzhe Chen
Alexandre Reuben
Linghua Wang
Junya Fujimoto
Jian Carrot-Zhang
Nicholas McGranahan
Lisha Ying
Junya Fukuoka
Chi-Wan Chow
Hoa H. N. Pham
Myrna C. B. Godoy
Brett W. Carter
Carmen Behrens
Jianhua Zhang
Mara B. Antonoff
Boris Sepesi
Yue Lu
Harvey I. Pass
Humam Kadara
Paul Scheet
Ara A. Vaporciyan
John V. Heymach
Ignacio I. Wistuba
J. Jack Lee
P. Andrew Futreal
Dan Su
Jean-Pierre J. Issa
Jianjun Zhang
author_sort Xin Hu
title Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas
title_short Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas
title_full Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas
title_fullStr Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas
title_full_unstemmed Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas
title_sort evolution of dna methylome from precancerous lesions to invasive lung adenocarcinomas
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/031719f1a9f8488a91a5917acd62743f
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