Population-Based Prevalence and 5-Year Change of Soft Drusen, Pseudodrusen, and Pachydrusen in a Japanese Population

Purpose: To elucidate the prevalence of soft drusen, pseudodrusen, and pachydrusen and their 5-year changes in a Japanese population. Design: Longitudinal population-based cohort study conducted from 2013 through 2017. Participants: Residents 40 years of age or older. Methods: Nonmydriatic color fun...

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Autores principales:	Miki Sato-Akushichi, MD, Reiko Kinouchi, MD, PhD, Satoshi Ishiko, MD, PhD, Kazuomi Hanada, MD, PhD, Hiroki Hayashi, Daiki Mikami, Shinji Ono, MD, PhD, Yasuo Yanagi, MD, PhD
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Drusen subtypes Longitudinal changes Pachydrusen Population-based cohort study Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/03240a7d0ec64457961214424bd5b076
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spelling	oai:doaj.org-article:03240a7d0ec64457961214424bd5b0762021-12-04T04:36:27ZPopulation-Based Prevalence and 5-Year Change of Soft Drusen, Pseudodrusen, and Pachydrusen in a Japanese Population2666-914510.1016/j.xops.2021.100081https://doaj.org/article/03240a7d0ec64457961214424bd5b0762021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S266691452100083Xhttps://doaj.org/toc/2666-9145Purpose: To elucidate the prevalence of soft drusen, pseudodrusen, and pachydrusen and their 5-year changes in a Japanese population. Design: Longitudinal population-based cohort study conducted from 2013 through 2017. Participants: Residents 40 years of age or older. Methods: Nonmydriatic color fundus photographs were used to grade drusen subtypes and retinal pigment epithelium (RPE) abnormalities according to the Three Continent Age-Related Macular Degeneration Consortium. The 5-year changes of each drusen were investigated. Main Outcome Measures: The prevalence of each drusen subtype and the 5-year changes of each drusen. Results: Among 1731 participants, 1660 participants had gradable photographs that were assessed. The age-adjusted prevalence of soft drusen, pachydrusen, and pseudodrusen was 4.3% (95% confidence interval [CI], 3.2%–5.8%), 7.7% (95% CI, 6.2%–9.7%), and 2.8% (95% CI, 1.7%–4.2%), respectively. Pachydrusen accounted for 82.0% (n = 50) of the extramacular drusen (n = 61). Pigment abnormalities were seen in 28.3% and 8.3% of eyes with soft drusen and pachydrusen, respectively (P < 0.0001). Longitudinal changes were investigated in 1444 participants with follow-up examinations, which showed an increase in size in 8.3% and 3.7% and regression in 1.7% and 5.5% for eyes with soft drusen and pachydrusen, respectively. No participants demonstrated RPE atrophy after pachydrusen regression. Conclusions: The prevalence of pachydrusen was higher than that of soft drusen and pseudodrusen combined. Pachydrusen may regress over time and typically is not associated with RPE atrophy as detected using color fundus photographs.Miki Sato-Akushichi, MDReiko Kinouchi, MD, PhDSatoshi Ishiko, MD, PhDKazuomi Hanada, MD, PhDHiroki HayashiDaiki MikamiShinji Ono, MD, PhDYasuo Yanagi, MD, PhDElsevierarticleDrusen subtypesLongitudinal changesPachydrusenPopulation-based cohort studyOphthalmologyRE1-994ENOphthalmology Science, Vol 1, Iss 4, Pp 100081- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Drusen subtypes Longitudinal changes Pachydrusen Population-based cohort study Ophthalmology RE1-994
spellingShingle	Drusen subtypes Longitudinal changes Pachydrusen Population-based cohort study Ophthalmology RE1-994 Miki Sato-Akushichi, MD Reiko Kinouchi, MD, PhD Satoshi Ishiko, MD, PhD Kazuomi Hanada, MD, PhD Hiroki Hayashi Daiki Mikami Shinji Ono, MD, PhD Yasuo Yanagi, MD, PhD Population-Based Prevalence and 5-Year Change of Soft Drusen, Pseudodrusen, and Pachydrusen in a Japanese Population
description	Purpose: To elucidate the prevalence of soft drusen, pseudodrusen, and pachydrusen and their 5-year changes in a Japanese population. Design: Longitudinal population-based cohort study conducted from 2013 through 2017. Participants: Residents 40 years of age or older. Methods: Nonmydriatic color fundus photographs were used to grade drusen subtypes and retinal pigment epithelium (RPE) abnormalities according to the Three Continent Age-Related Macular Degeneration Consortium. The 5-year changes of each drusen were investigated. Main Outcome Measures: The prevalence of each drusen subtype and the 5-year changes of each drusen. Results: Among 1731 participants, 1660 participants had gradable photographs that were assessed. The age-adjusted prevalence of soft drusen, pachydrusen, and pseudodrusen was 4.3% (95% confidence interval [CI], 3.2%–5.8%), 7.7% (95% CI, 6.2%–9.7%), and 2.8% (95% CI, 1.7%–4.2%), respectively. Pachydrusen accounted for 82.0% (n = 50) of the extramacular drusen (n = 61). Pigment abnormalities were seen in 28.3% and 8.3% of eyes with soft drusen and pachydrusen, respectively (P < 0.0001). Longitudinal changes were investigated in 1444 participants with follow-up examinations, which showed an increase in size in 8.3% and 3.7% and regression in 1.7% and 5.5% for eyes with soft drusen and pachydrusen, respectively. No participants demonstrated RPE atrophy after pachydrusen regression. Conclusions: The prevalence of pachydrusen was higher than that of soft drusen and pseudodrusen combined. Pachydrusen may regress over time and typically is not associated with RPE atrophy as detected using color fundus photographs.
format	article
author	Miki Sato-Akushichi, MD Reiko Kinouchi, MD, PhD Satoshi Ishiko, MD, PhD Kazuomi Hanada, MD, PhD Hiroki Hayashi Daiki Mikami Shinji Ono, MD, PhD Yasuo Yanagi, MD, PhD
author_facet	Miki Sato-Akushichi, MD Reiko Kinouchi, MD, PhD Satoshi Ishiko, MD, PhD Kazuomi Hanada, MD, PhD Hiroki Hayashi Daiki Mikami Shinji Ono, MD, PhD Yasuo Yanagi, MD, PhD
author_sort	Miki Sato-Akushichi, MD
title	Population-Based Prevalence and 5-Year Change of Soft Drusen, Pseudodrusen, and Pachydrusen in a Japanese Population
title_short	Population-Based Prevalence and 5-Year Change of Soft Drusen, Pseudodrusen, and Pachydrusen in a Japanese Population
title_full	Population-Based Prevalence and 5-Year Change of Soft Drusen, Pseudodrusen, and Pachydrusen in a Japanese Population
title_fullStr	Population-Based Prevalence and 5-Year Change of Soft Drusen, Pseudodrusen, and Pachydrusen in a Japanese Population
title_full_unstemmed	Population-Based Prevalence and 5-Year Change of Soft Drusen, Pseudodrusen, and Pachydrusen in a Japanese Population
title_sort	population-based prevalence and 5-year change of soft drusen, pseudodrusen, and pachydrusen in a japanese population
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/03240a7d0ec64457961214424bd5b076
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Population-Based Prevalence and 5-Year Change of Soft Drusen, Pseudodrusen, and Pachydrusen in a Japanese Population

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