Gray matter declines with age and hearing loss, but is partially maintained in tinnitus

Abstract The impact of age-related hearing loss extends beyond the auditory pathway and impacts brain areas related to cognitive impairment and even dementia. The presence of tinnitus, a sensation of sound that frequently co-occurs with hearing loss, is additionally linked to cognitive decline. Inte...

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Autores principales:	Elouise A. Koops, Emile de Kleine, Pim van Dijk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/03241f50a4a94012b1864bd3c9a4e08b
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spelling	oai:doaj.org-article:03241f50a4a94012b1864bd3c9a4e08b2021-12-02T11:43:58ZGray matter declines with age and hearing loss, but is partially maintained in tinnitus10.1038/s41598-020-78571-02045-2322https://doaj.org/article/03241f50a4a94012b1864bd3c9a4e08b2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78571-0https://doaj.org/toc/2045-2322Abstract The impact of age-related hearing loss extends beyond the auditory pathway and impacts brain areas related to cognitive impairment and even dementia. The presence of tinnitus, a sensation of sound that frequently co-occurs with hearing loss, is additionally linked to cognitive decline. Interestingly, structural neuroimaging studies have reported that hearing loss may precede or modulate the onset of cognitive impairment. In this study, we aimed to disentangle the effects of age, hearing loss, and tinnitus on gray matter structure. In total, 39 participants with hearing loss and tinnitus, 21 with hearing loss but without tinnitus, and 39 controls were included in this voxel- and surface-based morphometry MRI study. Whole brain volume and surface thickness measures were compared between the groups. Age-related gray matter volume decline was observed in all groups. Several brain areas showed smaller gray matter volume and cortical surface thickness in hearing loss without tinnitus, relative to controls. This reduction was observed both within and outside of the auditory pathway. Interestingly, these reductions were not observed in participants with tinnitus, who had similar hearing loss and were of similar age. Since we have tools to improve hearing loss, hearing screening may aid in the battle against cognitive decline.Elouise A. KoopsEmile de KleinePim van DijkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elouise A. Koops Emile de Kleine Pim van Dijk Gray matter declines with age and hearing loss, but is partially maintained in tinnitus
description	Abstract The impact of age-related hearing loss extends beyond the auditory pathway and impacts brain areas related to cognitive impairment and even dementia. The presence of tinnitus, a sensation of sound that frequently co-occurs with hearing loss, is additionally linked to cognitive decline. Interestingly, structural neuroimaging studies have reported that hearing loss may precede or modulate the onset of cognitive impairment. In this study, we aimed to disentangle the effects of age, hearing loss, and tinnitus on gray matter structure. In total, 39 participants with hearing loss and tinnitus, 21 with hearing loss but without tinnitus, and 39 controls were included in this voxel- and surface-based morphometry MRI study. Whole brain volume and surface thickness measures were compared between the groups. Age-related gray matter volume decline was observed in all groups. Several brain areas showed smaller gray matter volume and cortical surface thickness in hearing loss without tinnitus, relative to controls. This reduction was observed both within and outside of the auditory pathway. Interestingly, these reductions were not observed in participants with tinnitus, who had similar hearing loss and were of similar age. Since we have tools to improve hearing loss, hearing screening may aid in the battle against cognitive decline.
format	article
author	Elouise A. Koops Emile de Kleine Pim van Dijk
author_facet	Elouise A. Koops Emile de Kleine Pim van Dijk
author_sort	Elouise A. Koops
title	Gray matter declines with age and hearing loss, but is partially maintained in tinnitus
title_short	Gray matter declines with age and hearing loss, but is partially maintained in tinnitus
title_full	Gray matter declines with age and hearing loss, but is partially maintained in tinnitus
title_fullStr	Gray matter declines with age and hearing loss, but is partially maintained in tinnitus
title_full_unstemmed	Gray matter declines with age and hearing loss, but is partially maintained in tinnitus
title_sort	gray matter declines with age and hearing loss, but is partially maintained in tinnitus
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/03241f50a4a94012b1864bd3c9a4e08b
work_keys_str_mv	AT elouiseakoops graymatterdeclineswithageandhearinglossbutispartiallymaintainedintinnitus AT emiledekleine graymatterdeclineswithageandhearinglossbutispartiallymaintainedintinnitus AT pimvandijk graymatterdeclineswithageandhearinglossbutispartiallymaintainedintinnitus
_version_	1718395322335494144

Gray matter declines with age and hearing loss, but is partially maintained in tinnitus

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