The impact of the Th17:Treg axis on the IgA-Biome across the glycemic spectrum.

Secretory IgA (SIgA) is released into mucosal surfaces where its function extends beyond that of host defense to include the shaping of resident microbial communities by mediating exclusion/inclusion of respective microbes and regulating bacterial gene expression. In this capacity, SIgA acts as the...

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Autores principales:	Heather T Essigmann, Kristi L Hoffman, Joseph F Petrosino, Goo Jun, David Aguilar, Craig L Hanis, Herbert L DuPont, Eric L Brown
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0324ed888d4c44ccb83aef011272f046
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spelling	oai:doaj.org-article:0324ed888d4c44ccb83aef011272f0462021-12-02T20:16:43ZThe impact of the Th17:Treg axis on the IgA-Biome across the glycemic spectrum.1932-620310.1371/journal.pone.0258812https://doaj.org/article/0324ed888d4c44ccb83aef011272f0462021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258812https://doaj.org/toc/1932-6203Secretory IgA (SIgA) is released into mucosal surfaces where its function extends beyond that of host defense to include the shaping of resident microbial communities by mediating exclusion/inclusion of respective microbes and regulating bacterial gene expression. In this capacity, SIgA acts as the fulcrum on which host immunity and the health of the microbiota are balanced. We recently completed an analysis of the gut and salivary IgA-Biomes (16S rDNA sequencing of SIgA-coated/uncoated bacteria) in Mexican-American adults that identified IgA-Biome differences across the glycemic spectrum. As Th17:Treg ratio imbalances are associated with gut microbiome dysbiosis and chronic inflammatory conditions such as type 2 diabetes, the present study extends our prior work by examining the impact of Th17:Treg ratios (pro-inflammatory:anti-inflammatory T-cell ratios) and the SIgA response (Th17:Treg-SIgA axis) in shaping microbial communities. Examining the impact of Th17:Treg ratios (determined by epigenetic qPCR lymphocyte subset quantification) on the IgA-Biome across diabetes phenotypes identified a proportional relationship between Th17:Treg ratios and alpha diversity in the stool IgA-Biome of those with dysglycemia, significant changes in community composition of the stool and salivary microbiomes across glycemic profiles, and genera preferentially abundant by T-cell inflammatory phenotype. This is the first study to associate epigenetically quantified Th17:Treg ratios with both the larger and SIgA-fractionated microbiome, assess these associations in the context of a chronic inflammatory disease, and offers a novel frame through which to evaluate mucosal microbiomes in the context of host responses and inflammation.Heather T EssigmannKristi L HoffmanJoseph F PetrosinoGoo JunDavid AguilarCraig L HanisHerbert L DuPontEric L BrownPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258812 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Heather T Essigmann Kristi L Hoffman Joseph F Petrosino Goo Jun David Aguilar Craig L Hanis Herbert L DuPont Eric L Brown The impact of the Th17:Treg axis on the IgA-Biome across the glycemic spectrum.
description	Secretory IgA (SIgA) is released into mucosal surfaces where its function extends beyond that of host defense to include the shaping of resident microbial communities by mediating exclusion/inclusion of respective microbes and regulating bacterial gene expression. In this capacity, SIgA acts as the fulcrum on which host immunity and the health of the microbiota are balanced. We recently completed an analysis of the gut and salivary IgA-Biomes (16S rDNA sequencing of SIgA-coated/uncoated bacteria) in Mexican-American adults that identified IgA-Biome differences across the glycemic spectrum. As Th17:Treg ratio imbalances are associated with gut microbiome dysbiosis and chronic inflammatory conditions such as type 2 diabetes, the present study extends our prior work by examining the impact of Th17:Treg ratios (pro-inflammatory:anti-inflammatory T-cell ratios) and the SIgA response (Th17:Treg-SIgA axis) in shaping microbial communities. Examining the impact of Th17:Treg ratios (determined by epigenetic qPCR lymphocyte subset quantification) on the IgA-Biome across diabetes phenotypes identified a proportional relationship between Th17:Treg ratios and alpha diversity in the stool IgA-Biome of those with dysglycemia, significant changes in community composition of the stool and salivary microbiomes across glycemic profiles, and genera preferentially abundant by T-cell inflammatory phenotype. This is the first study to associate epigenetically quantified Th17:Treg ratios with both the larger and SIgA-fractionated microbiome, assess these associations in the context of a chronic inflammatory disease, and offers a novel frame through which to evaluate mucosal microbiomes in the context of host responses and inflammation.
format	article
author	Heather T Essigmann Kristi L Hoffman Joseph F Petrosino Goo Jun David Aguilar Craig L Hanis Herbert L DuPont Eric L Brown
author_facet	Heather T Essigmann Kristi L Hoffman Joseph F Petrosino Goo Jun David Aguilar Craig L Hanis Herbert L DuPont Eric L Brown
author_sort	Heather T Essigmann
title	The impact of the Th17:Treg axis on the IgA-Biome across the glycemic spectrum.
title_short	The impact of the Th17:Treg axis on the IgA-Biome across the glycemic spectrum.
title_full	The impact of the Th17:Treg axis on the IgA-Biome across the glycemic spectrum.
title_fullStr	The impact of the Th17:Treg axis on the IgA-Biome across the glycemic spectrum.
title_full_unstemmed	The impact of the Th17:Treg axis on the IgA-Biome across the glycemic spectrum.
title_sort	impact of the th17:treg axis on the iga-biome across the glycemic spectrum.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0324ed888d4c44ccb83aef011272f046
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The impact of the Th17:Treg axis on the IgA-Biome across the glycemic spectrum.

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