A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions
Francesco Faraldi,1 Vincenzo Papa,2 Debora Santoro,2 Daria Rasà,2 Annamaria L Mazza,2 Maria M Rabbione,1 Simona Russo21Department of Ophthalmology III, Presidio Ospedaliero Oftalmico, Torino, Italy; 2SIFI SpA, Catania, ItalyPurpose: The aim of this study was to investigate the effects...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2012
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/032577abf9404617a5d22630ded577ac |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:032577abf9404617a5d22630ded577ac |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:032577abf9404617a5d22630ded577ac2021-12-02T05:30:39ZA new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions1177-54671177-5483https://doaj.org/article/032577abf9404617a5d22630ded577ac2012-05-01T00:00:00Zhttp://www.dovepress.com/a-new-eye-gel-containing-sodium-hyaluronate-and-xanthan-gum-for-the-ma-a9868https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Francesco Faraldi,1 Vincenzo Papa,2 Debora Santoro,2 Daria Rasà,2 Annamaria L Mazza,2 Maria M Rabbione,1 Simona Russo21Department of Ophthalmology III, Presidio Ospedaliero Oftalmico, Torino, Italy; 2SIFI SpA, Catania, ItalyPurpose: The aim of this study was to investigate the effects of an ophthalmic gel containing sodium hyaluronate and xanthan gum in addition to the antibiotic netilmicin in the management of traumatic corneal abrasions.Patients and methods: Patients with traumatic corneal abrasions were randomly treated as follows: Group A (n = 20) with an occlusive patching for 12 hours plus one drop of an eye gel containing 0.15% sodium hyaluronate, 1% xanthan gum and 0.3% netilmicin qid for 5 days; and Group B (n = 20) with an occlusive patching for 2–3 days plus one application of 0.3% netilmicin ophthalmic ointment qid for 5 days. All patients were evaluated after the third and seventh day by slit-lamp examination, fluorescein staining, and corneal defect photograph in order to assess corneal re-epithelialization. Conjunctival hyperaemia, lid oedema, subjective symptoms of discomfort, and conjunctival swabs were also evaluated.Results: No statistically significant difference was observed between the groups in terms of the extent of corneal healing after 3 days of treatment. Both treatments were also highly effective in decreasing the erosion score and the conjunctival hyperemia (P < 0.0001, P < 0.005, respectively) without any significant difference between the two types of treatment. Subjective symptoms of discomfort and conjunctival swabs were also evaluated.Conclusion: In the management of traumatic corneal abrasions, the administration of an eye gel containing sodium hyaluronate and xanthan gum is able to reduce the length of occlusive patching. In addition, the presence of netilmicin guarantees good antibiotic prophylaxis during the wound repair process.Keywords: netilmicin, xanthan gum, wound healing, patching, corneal abrasionFaraldi FPapa VSantoro DRasà DMazza ALRabbione MMRusso SDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 727-731 (2012) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Ophthalmology RE1-994 |
| spellingShingle |
Ophthalmology RE1-994 Faraldi F Papa V Santoro D Rasà D Mazza AL Rabbione MM Russo S A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions |
| description |
Francesco Faraldi,1 Vincenzo Papa,2 Debora Santoro,2 Daria Rasà,2 Annamaria L Mazza,2 Maria M Rabbione,1 Simona Russo21Department of Ophthalmology III, Presidio Ospedaliero Oftalmico, Torino, Italy; 2SIFI SpA, Catania, ItalyPurpose: The aim of this study was to investigate the effects of an ophthalmic gel containing sodium hyaluronate and xanthan gum in addition to the antibiotic netilmicin in the management of traumatic corneal abrasions.Patients and methods: Patients with traumatic corneal abrasions were randomly treated as follows: Group A (n = 20) with an occlusive patching for 12 hours plus one drop of an eye gel containing 0.15% sodium hyaluronate, 1% xanthan gum and 0.3% netilmicin qid for 5 days; and Group B (n = 20) with an occlusive patching for 2–3 days plus one application of 0.3% netilmicin ophthalmic ointment qid for 5 days. All patients were evaluated after the third and seventh day by slit-lamp examination, fluorescein staining, and corneal defect photograph in order to assess corneal re-epithelialization. Conjunctival hyperaemia, lid oedema, subjective symptoms of discomfort, and conjunctival swabs were also evaluated.Results: No statistically significant difference was observed between the groups in terms of the extent of corneal healing after 3 days of treatment. Both treatments were also highly effective in decreasing the erosion score and the conjunctival hyperemia (P < 0.0001, P < 0.005, respectively) without any significant difference between the two types of treatment. Subjective symptoms of discomfort and conjunctival swabs were also evaluated.Conclusion: In the management of traumatic corneal abrasions, the administration of an eye gel containing sodium hyaluronate and xanthan gum is able to reduce the length of occlusive patching. In addition, the presence of netilmicin guarantees good antibiotic prophylaxis during the wound repair process.Keywords: netilmicin, xanthan gum, wound healing, patching, corneal abrasion |
| format |
article |
| author |
Faraldi F Papa V Santoro D Rasà D Mazza AL Rabbione MM Russo S |
| author_facet |
Faraldi F Papa V Santoro D Rasà D Mazza AL Rabbione MM Russo S |
| author_sort |
Faraldi F |
| title |
A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions |
| title_short |
A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions |
| title_full |
A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions |
| title_fullStr |
A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions |
| title_full_unstemmed |
A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions |
| title_sort |
new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions |
| publisher |
Dove Medical Press |
| publishDate |
2012 |
| url |
https://doaj.org/article/032577abf9404617a5d22630ded577ac |
| work_keys_str_mv |
AT faraldif aneweyegelcontainingsodiumhyaluronateandxanthangumforthemanagementofposttraumaticcornealabrasions AT papav aneweyegelcontainingsodiumhyaluronateandxanthangumforthemanagementofposttraumaticcornealabrasions AT santorod aneweyegelcontainingsodiumhyaluronateandxanthangumforthemanagementofposttraumaticcornealabrasions AT rasampagraved aneweyegelcontainingsodiumhyaluronateandxanthangumforthemanagementofposttraumaticcornealabrasions AT mazzaal aneweyegelcontainingsodiumhyaluronateandxanthangumforthemanagementofposttraumaticcornealabrasions AT rabbionemm aneweyegelcontainingsodiumhyaluronateandxanthangumforthemanagementofposttraumaticcornealabrasions AT russos aneweyegelcontainingsodiumhyaluronateandxanthangumforthemanagementofposttraumaticcornealabrasions AT faraldif neweyegelcontainingsodiumhyaluronateandxanthangumforthemanagementofposttraumaticcornealabrasions AT papav neweyegelcontainingsodiumhyaluronateandxanthangumforthemanagementofposttraumaticcornealabrasions AT santorod neweyegelcontainingsodiumhyaluronateandxanthangumforthemanagementofposttraumaticcornealabrasions AT rasampagraved neweyegelcontainingsodiumhyaluronateandxanthangumforthemanagementofposttraumaticcornealabrasions AT mazzaal neweyegelcontainingsodiumhyaluronateandxanthangumforthemanagementofposttraumaticcornealabrasions AT rabbionemm neweyegelcontainingsodiumhyaluronateandxanthangumforthemanagementofposttraumaticcornealabrasions AT russos neweyegelcontainingsodiumhyaluronateandxanthangumforthemanagementofposttraumaticcornealabrasions |
| _version_ |
1718400332651823104 |