Hepatic progenitors for liver disease: current position

Alice Conigliaro1, David A Brenner2, Tatiana Kisseleva21University &ldquo;La Sapienza&rdquo;, Dipartimento di Biotecnologie Cellulari ed Ematologia Policlinico Umberto I, V Clinica Medica, Rome, Italy; 2Department of Medicine, University of California, San Diego, La Jolla, CA, USAAbs...

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Autores principales:	Alice Conigliaro, David A Brenner, Tatiana Kisseleva
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/032634ac12b34e7db0b9be89c44d7e41
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spelling	oai:doaj.org-article:032634ac12b34e7db0b9be89c44d7e412021-12-02T00:59:08ZHepatic progenitors for liver disease: current position1178-6957https://doaj.org/article/032634ac12b34e7db0b9be89c44d7e412010-02-01T00:00:00Zhttp://www.dovepress.com/hepatic-progenitors-for-liver-disease-current-position-a4005https://doaj.org/toc/1178-6957Alice Conigliaro1, David A Brenner2, Tatiana Kisseleva21University &ldquo;La Sapienza&rdquo;, Dipartimento di Biotecnologie Cellulari ed Ematologia Policlinico Umberto I, V Clinica Medica, Rome, Italy; 2Department of Medicine, University of California, San Diego, La Jolla, CA, USAAbstract: Liver regeneration restores the original functionality of hepatocytes and cholangiocytes in response to injury. It is regulated on several levels, with different cellular populations contributing to this process, eg, hepatocytes, liver precursor cells, intrahepatic stem cells. In response to injury, mature hepatocytes have the capability to proliferate and give rise to new hepatocytes and cholangiocytes. Meanwhile, liver precursor cells (oval cells) have become the most recognized bipotential precursor cells in the damaged liver. They rapidly proliferate, change their cellular composition, and differentiate into hepatocytes and cholangiocytes to compensate for the cellular loss and maintain liver homeostasis. There is a growing body of evidence that oval cells originate from the intrahepatic stem cell(s), which in turn give(s) rise to epithelial, including oval cells, and/or other hepatic cells of nonepithelial origin. Since there is a close relationship between the liver and hematopoiesis, bone marrow derived cells can also contribute to liver regeneration by the fusion of myeloid cells with damaged hepatocytes, or differentiation of mesenchymal stem cells into hepatocyte-like cells. The current review discusses the contribution of different cells to liver regeneration and their characteristics.Keywords: hepatic progenitor, liver disease, liver precursor cells, oval cells, hepatocytes, intrahepatic stem cells, cholangiocytes Alice ConigliaroDavid A BrennerTatiana KisselevaDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2010, Iss default, Pp 39-47 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Alice Conigliaro David A Brenner Tatiana Kisseleva Hepatic progenitors for liver disease: current position
description	Alice Conigliaro1, David A Brenner2, Tatiana Kisseleva21University &ldquo;La Sapienza&rdquo;, Dipartimento di Biotecnologie Cellulari ed Ematologia Policlinico Umberto I, V Clinica Medica, Rome, Italy; 2Department of Medicine, University of California, San Diego, La Jolla, CA, USAAbstract: Liver regeneration restores the original functionality of hepatocytes and cholangiocytes in response to injury. It is regulated on several levels, with different cellular populations contributing to this process, eg, hepatocytes, liver precursor cells, intrahepatic stem cells. In response to injury, mature hepatocytes have the capability to proliferate and give rise to new hepatocytes and cholangiocytes. Meanwhile, liver precursor cells (oval cells) have become the most recognized bipotential precursor cells in the damaged liver. They rapidly proliferate, change their cellular composition, and differentiate into hepatocytes and cholangiocytes to compensate for the cellular loss and maintain liver homeostasis. There is a growing body of evidence that oval cells originate from the intrahepatic stem cell(s), which in turn give(s) rise to epithelial, including oval cells, and/or other hepatic cells of nonepithelial origin. Since there is a close relationship between the liver and hematopoiesis, bone marrow derived cells can also contribute to liver regeneration by the fusion of myeloid cells with damaged hepatocytes, or differentiation of mesenchymal stem cells into hepatocyte-like cells. The current review discusses the contribution of different cells to liver regeneration and their characteristics.Keywords: hepatic progenitor, liver disease, liver precursor cells, oval cells, hepatocytes, intrahepatic stem cells, cholangiocytes
format	article
author	Alice Conigliaro David A Brenner Tatiana Kisseleva
author_facet	Alice Conigliaro David A Brenner Tatiana Kisseleva
author_sort	Alice Conigliaro
title	Hepatic progenitors for liver disease: current position
title_short	Hepatic progenitors for liver disease: current position
title_full	Hepatic progenitors for liver disease: current position
title_fullStr	Hepatic progenitors for liver disease: current position
title_full_unstemmed	Hepatic progenitors for liver disease: current position
title_sort	hepatic progenitors for liver disease: current position
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/032634ac12b34e7db0b9be89c44d7e41
work_keys_str_mv	AT aliceconigliaro hepaticprogenitorsforliverdiseasecurrentposition AT davidabrenner hepaticprogenitorsforliverdiseasecurrentposition AT tatianakisseleva hepaticprogenitorsforliverdiseasecurrentposition
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Hepatic progenitors for liver disease: current position

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