Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

Enzymes of the six-transmembrane epithelial antigen of the prostate (STEAP) family reduce Fe3+ and Cu2+ ions to facilitate metal-ion uptake by mammalian cells. Here, authors employ single-particle cryo-EM to gain insights into the molecular principles of iron reduction by human STEAP4 .

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Autores principales: Wout Oosterheert, Laura S. van Bezouwen, Remco N. P. Rodenburg, Joke Granneman, Friedrich Förster, Andrea Mattevi, Piet Gros
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/0327e5d4fe7d44afad92e8cf690996b4
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