Serum Ferritin Independently Predicts the Incidence of Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus

Yun Hong Wu, Su Yuan Wang, Ming Xia Li, Hua He, Wei Jin Yin, Yan Hong Guo, Hui Qin Zhang, Zeng Mei Sun, Dan Zhang, Xi Wang, Shu Yao Sun, Shu Xi Tang, Rong Du, Cheng Hui Zhang Department of Endocrinology and Metabolism, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous...

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Autores principales:	Wu YH, Wang SY, Li MX, He H, Yin WJ, Guo YH, Zhang HQ, Sun ZM, Zhang D, Wang X, Sun SY, Tang SX, Du R, Zhang CH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	serum ferritin chronic kidney disease type 2 diabetes mellitus Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/032abc7cda9140e9b89f4fe52c9dbaa4
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spelling	oai:doaj.org-article:032abc7cda9140e9b89f4fe52c9dbaa42021-12-02T09:46:23ZSerum Ferritin Independently Predicts the Incidence of Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus1178-7007https://doaj.org/article/032abc7cda9140e9b89f4fe52c9dbaa42020-01-01T00:00:00Zhttps://www.dovepress.com/serum-ferritin-independently-predicts-the-incidence-of-chronic-kidney--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Yun Hong Wu, Su Yuan Wang, Ming Xia Li, Hua He, Wei Jin Yin, Yan Hong Guo, Hui Qin Zhang, Zeng Mei Sun, Dan Zhang, Xi Wang, Shu Yao Sun, Shu Xi Tang, Rong Du, Cheng Hui Zhang Department of Endocrinology and Metabolism, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region, Chengdu, People’s Republic of ChinaCorrespondence: Cheng Hui ZhangDepartment of Endocrinology and Metabolism, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region, No. 20 Ximianqiao Street, Chengdu, Sichuan 610041, People’s Republic of ChinaEmail zchscu0616@163.comAim: This study aimed to determine whether serum ferritin (SF) is an independent risk factor of the incidence of chronic kidney disease (CKD) and rapid renal function decline (RFD) in male Tibetan patients with type 2 diabetes mellitus (T2DM).Methods: We performed a retrospective cohort study that included 191 male Tibetan patients with T2DM without CKD. Patients were divided into three groups according to the level of SF. The following outcomes were measured: cumulative incidence of chronic kidney disease [i.e. estimated glomerular filtration rate (eGFR) < 60 mL/min per 1.73 m 2 and/or urinary albumin/creatine ratio (ACR) ≥ 30 mg/g] and RFD (i.e. decrease in eGFR of ≥ 25% from baseline or a decline rate of ≥ 3 mL/min per 1.73 m 2 annually).Results: In total, over a median follow-up period of 23 months, 30 (15.7%) and 89 patients (46.6%) developed CKD and RFD. In multivariable Cox models, a 100 ng/mL increment in SF was associated with a 1.12-fold (95% CI: 1.02– 1.24) higher adjusted risk for incidence of CKD. The adjusted-HR of CKD was 1.31 (95% CI: 0.38– 4.53) and 2.92 (95% CI: 0.87– 9.77) for those in tertile 2 and tertile 3, respectively, compared with the patients in tertile 1. However, SF was not significantly associated with RFD (adjusted-HR: 1.06, 95% CI: 0.99– 1.14).Conclusion: Serum ferritin independently predicts the incidence of CKD in male Tibetan patients with T2DM. High levels of serum ferritin may play a role in the pathogenesis leading to the development of CKD in T2DM.Keywords: serum ferritin, chronic kidney disease, type 2 diabetes mellitusWu YHWang SYLi MXHe HYin WJGuo YHZhang HQSun ZMZhang DWang XSun SYTang SXDu RZhang CHDove Medical Pressarticleserum ferritinchronic kidney diseasetype 2 diabetes mellitusSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 99-105 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	serum ferritin chronic kidney disease type 2 diabetes mellitus Specialties of internal medicine RC581-951
spellingShingle	serum ferritin chronic kidney disease type 2 diabetes mellitus Specialties of internal medicine RC581-951 Wu YH Wang SY Li MX He H Yin WJ Guo YH Zhang HQ Sun ZM Zhang D Wang X Sun SY Tang SX Du R Zhang CH Serum Ferritin Independently Predicts the Incidence of Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus
description	Yun Hong Wu, Su Yuan Wang, Ming Xia Li, Hua He, Wei Jin Yin, Yan Hong Guo, Hui Qin Zhang, Zeng Mei Sun, Dan Zhang, Xi Wang, Shu Yao Sun, Shu Xi Tang, Rong Du, Cheng Hui Zhang Department of Endocrinology and Metabolism, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region, Chengdu, People’s Republic of ChinaCorrespondence: Cheng Hui ZhangDepartment of Endocrinology and Metabolism, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region, No. 20 Ximianqiao Street, Chengdu, Sichuan 610041, People’s Republic of ChinaEmail zchscu0616@163.comAim: This study aimed to determine whether serum ferritin (SF) is an independent risk factor of the incidence of chronic kidney disease (CKD) and rapid renal function decline (RFD) in male Tibetan patients with type 2 diabetes mellitus (T2DM).Methods: We performed a retrospective cohort study that included 191 male Tibetan patients with T2DM without CKD. Patients were divided into three groups according to the level of SF. The following outcomes were measured: cumulative incidence of chronic kidney disease [i.e. estimated glomerular filtration rate (eGFR) < 60 mL/min per 1.73 m 2 and/or urinary albumin/creatine ratio (ACR) ≥ 30 mg/g] and RFD (i.e. decrease in eGFR of ≥ 25% from baseline or a decline rate of ≥ 3 mL/min per 1.73 m 2 annually).Results: In total, over a median follow-up period of 23 months, 30 (15.7%) and 89 patients (46.6%) developed CKD and RFD. In multivariable Cox models, a 100 ng/mL increment in SF was associated with a 1.12-fold (95% CI: 1.02– 1.24) higher adjusted risk for incidence of CKD. The adjusted-HR of CKD was 1.31 (95% CI: 0.38– 4.53) and 2.92 (95% CI: 0.87– 9.77) for those in tertile 2 and tertile 3, respectively, compared with the patients in tertile 1. However, SF was not significantly associated with RFD (adjusted-HR: 1.06, 95% CI: 0.99– 1.14).Conclusion: Serum ferritin independently predicts the incidence of CKD in male Tibetan patients with T2DM. High levels of serum ferritin may play a role in the pathogenesis leading to the development of CKD in T2DM.Keywords: serum ferritin, chronic kidney disease, type 2 diabetes mellitus
format	article
author	Wu YH Wang SY Li MX He H Yin WJ Guo YH Zhang HQ Sun ZM Zhang D Wang X Sun SY Tang SX Du R Zhang CH
author_facet	Wu YH Wang SY Li MX He H Yin WJ Guo YH Zhang HQ Sun ZM Zhang D Wang X Sun SY Tang SX Du R Zhang CH
author_sort	Wu YH
title	Serum Ferritin Independently Predicts the Incidence of Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus
title_short	Serum Ferritin Independently Predicts the Incidence of Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus
title_full	Serum Ferritin Independently Predicts the Incidence of Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus
title_fullStr	Serum Ferritin Independently Predicts the Incidence of Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus
title_full_unstemmed	Serum Ferritin Independently Predicts the Incidence of Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus
title_sort	serum ferritin independently predicts the incidence of chronic kidney disease in patients with type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/032abc7cda9140e9b89f4fe52c9dbaa4
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Serum Ferritin Independently Predicts the Incidence of Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus

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