Preclinical screening for retinopathy of prematurity risk using IGF1 levels at 3 weeks post-partum.

Following current recommendations for preventing retinopathy of prematurity (ROP) involves screening a large number of patients. We performed a prospective study to establish a useful screening system for ROP prediction and we have determined that measuring serum levels of IGF1 at week three and the...

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Autores principales:	Alejandro Pérez-Muñuzuri, Maria Luz Couce-Pico, Ana Baña-Souto, Olalla López-Suárez, Alicia Iglesias-Deus, José Blanco-Teijeiro, José Ramón Fernández-Lorenzo, José María Fraga-Bermúdez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/032ba636318a4fd29af918ca0203206a
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spelling	oai:doaj.org-article:032ba636318a4fd29af918ca0203206a2021-11-18T08:32:55ZPreclinical screening for retinopathy of prematurity risk using IGF1 levels at 3 weeks post-partum.1932-620310.1371/journal.pone.0088781https://doaj.org/article/032ba636318a4fd29af918ca0203206a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24523937/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Following current recommendations for preventing retinopathy of prematurity (ROP) involves screening a large number of patients. We performed a prospective study to establish a useful screening system for ROP prediction and we have determined that measuring serum levels of IGF1 at week three and the presence of sepsis have a high predictive value for the subsequent development of ROP. A total of 145 premature newborn, with birthweight <1500 g and/or <32 weeks gestational age, were enrolled. 26.9% of them showed some form of retinopathy. A significant association was found between the development of retinopathy and each of the following variables: early gestational age, low birthweight, requiring mechanical ventilation, oxygen treatment, intracranial haemorrhage, sepsis during the first three weeks, bronchopulmonary dysplasia, the need for erythrocyte transfusion, erythropoietin treatment, and low levels of serum IGF1 in the third week. A multiple logistic regression analysis was used to obtain curves for the probability of developing ROP, based on the main factors linked with ROP, namely serum levels of IGF1 and presence of sepsis. Such preclinical screening has the ability to identify patients with high-risk of developing retinopathy and should lead to better prediction for ROP, while at the same time optimising the use of clinical resources, both human and material.Alejandro Pérez-MuñuzuriMaria Luz Couce-PicoAna Baña-SoutoOlalla López-SuárezAlicia Iglesias-DeusJosé Blanco-TeijeiroJosé Ramón Fernández-LorenzoJosé María Fraga-BermúdezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88781 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alejandro Pérez-Muñuzuri Maria Luz Couce-Pico Ana Baña-Souto Olalla López-Suárez Alicia Iglesias-Deus José Blanco-Teijeiro José Ramón Fernández-Lorenzo José María Fraga-Bermúdez Preclinical screening for retinopathy of prematurity risk using IGF1 levels at 3 weeks post-partum.
description	Following current recommendations for preventing retinopathy of prematurity (ROP) involves screening a large number of patients. We performed a prospective study to establish a useful screening system for ROP prediction and we have determined that measuring serum levels of IGF1 at week three and the presence of sepsis have a high predictive value for the subsequent development of ROP. A total of 145 premature newborn, with birthweight <1500 g and/or <32 weeks gestational age, were enrolled. 26.9% of them showed some form of retinopathy. A significant association was found between the development of retinopathy and each of the following variables: early gestational age, low birthweight, requiring mechanical ventilation, oxygen treatment, intracranial haemorrhage, sepsis during the first three weeks, bronchopulmonary dysplasia, the need for erythrocyte transfusion, erythropoietin treatment, and low levels of serum IGF1 in the third week. A multiple logistic regression analysis was used to obtain curves for the probability of developing ROP, based on the main factors linked with ROP, namely serum levels of IGF1 and presence of sepsis. Such preclinical screening has the ability to identify patients with high-risk of developing retinopathy and should lead to better prediction for ROP, while at the same time optimising the use of clinical resources, both human and material.
format	article
author	Alejandro Pérez-Muñuzuri Maria Luz Couce-Pico Ana Baña-Souto Olalla López-Suárez Alicia Iglesias-Deus José Blanco-Teijeiro José Ramón Fernández-Lorenzo José María Fraga-Bermúdez
author_facet	Alejandro Pérez-Muñuzuri Maria Luz Couce-Pico Ana Baña-Souto Olalla López-Suárez Alicia Iglesias-Deus José Blanco-Teijeiro José Ramón Fernández-Lorenzo José María Fraga-Bermúdez
author_sort	Alejandro Pérez-Muñuzuri
title	Preclinical screening for retinopathy of prematurity risk using IGF1 levels at 3 weeks post-partum.
title_short	Preclinical screening for retinopathy of prematurity risk using IGF1 levels at 3 weeks post-partum.
title_full	Preclinical screening for retinopathy of prematurity risk using IGF1 levels at 3 weeks post-partum.
title_fullStr	Preclinical screening for retinopathy of prematurity risk using IGF1 levels at 3 weeks post-partum.
title_full_unstemmed	Preclinical screening for retinopathy of prematurity risk using IGF1 levels at 3 weeks post-partum.
title_sort	preclinical screening for retinopathy of prematurity risk using igf1 levels at 3 weeks post-partum.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/032ba636318a4fd29af918ca0203206a
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Preclinical screening for retinopathy of prematurity risk using IGF1 levels at 3 weeks post-partum.

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