Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs.

We investigated the association between repeat polymorphism in intron 4 of the tyrosine hydroxylase (TH) gene and two personality traits, activity-impulsivity and inattention, in German Shepherd Dogs. The behaviour of 104 dogs was characterized by two instruments: (1) the previously validated Dog-At...

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Auteurs principaux:	Eniko Kubinyi, Judit Vas, Krisztina Hejjas, Zsolt Ronai, Ildikó Brúder, Borbála Turcsán, Maria Sasvari-Szekely, Adám Miklósi
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2012
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/032c4851e6c34812b28b3a4477b4da4b
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spelling	oai:doaj.org-article:032c4851e6c34812b28b3a4477b4da4b2021-11-18T07:30:01ZPolymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs.1932-620310.1371/journal.pone.0030271https://doaj.org/article/032c4851e6c34812b28b3a4477b4da4b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22272320/?tool=EBIhttps://doaj.org/toc/1932-6203We investigated the association between repeat polymorphism in intron 4 of the tyrosine hydroxylase (TH) gene and two personality traits, activity-impulsivity and inattention, in German Shepherd Dogs. The behaviour of 104 dogs was characterized by two instruments: (1) the previously validated Dog-Attention Deficit Hyperactivity Disorder Rating Scale (Dog-ADHD RS) filled in by the dog owners and (2) the newly developed Activity-impulsivity Behavioural Scale (AIBS) containing four subtests, scored by the experimenters. Internal consistency, inter-observer reliability, test-retest reliability and convergent validity were demonstrated for AIBS. Dogs possessing at least one short allele were proved to be more active-impulsive by both instruments, compared to dogs carrying two copies of the long allele (activity-impulsivity scale of Dog-ADHD RS: p = 0.007; AIBS: p = 0.023). The results have some potential to support human studies; however, further research should reveal the molecular function of the TH gene variants, and look for the effect in more breeds.Eniko KubinyiJudit VasKrisztina HejjasZsolt RonaiIldikó BrúderBorbála TurcsánMaria Sasvari-SzekelyAdám MiklósiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e30271 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eniko Kubinyi Judit Vas Krisztina Hejjas Zsolt Ronai Ildikó Brúder Borbála Turcsán Maria Sasvari-Szekely Adám Miklósi Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs.
description	We investigated the association between repeat polymorphism in intron 4 of the tyrosine hydroxylase (TH) gene and two personality traits, activity-impulsivity and inattention, in German Shepherd Dogs. The behaviour of 104 dogs was characterized by two instruments: (1) the previously validated Dog-Attention Deficit Hyperactivity Disorder Rating Scale (Dog-ADHD RS) filled in by the dog owners and (2) the newly developed Activity-impulsivity Behavioural Scale (AIBS) containing four subtests, scored by the experimenters. Internal consistency, inter-observer reliability, test-retest reliability and convergent validity were demonstrated for AIBS. Dogs possessing at least one short allele were proved to be more active-impulsive by both instruments, compared to dogs carrying two copies of the long allele (activity-impulsivity scale of Dog-ADHD RS: p = 0.007; AIBS: p = 0.023). The results have some potential to support human studies; however, further research should reveal the molecular function of the TH gene variants, and look for the effect in more breeds.
format	article
author	Eniko Kubinyi Judit Vas Krisztina Hejjas Zsolt Ronai Ildikó Brúder Borbála Turcsán Maria Sasvari-Szekely Adám Miklósi
author_facet	Eniko Kubinyi Judit Vas Krisztina Hejjas Zsolt Ronai Ildikó Brúder Borbála Turcsán Maria Sasvari-Szekely Adám Miklósi
author_sort	Eniko Kubinyi
title	Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs.
title_short	Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs.
title_full	Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs.
title_fullStr	Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs.
title_full_unstemmed	Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs.
title_sort	polymorphism in the tyrosine hydroxylase (th) gene is associated with activity-impulsivity in german shepherd dogs.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/032c4851e6c34812b28b3a4477b4da4b
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Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs.

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