Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility

Single nucleotide variants (SNVs) can affect chromatin occupancy by transcription factors (TF). Here the authors mine naturally occurring SNVs to probe cis elements and define contextual sequences that govern in vivo transcription factor chromatin occupancy and chromatin accessibility.

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Autores principales:	Vivek Behera, Perry Evans, Carolyne J. Face, Nicole Hamagami, Laavanya Sankaranarayanan, Cheryl A. Keller, Belinda Giardine, Kai Tan, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/032dd8c8b9bf4b20820beaeaca430843
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spelling	oai:doaj.org-article:032dd8c8b9bf4b20820beaeaca4308432021-12-02T14:40:43ZExploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility10.1038/s41467-018-03082-62041-1723https://doaj.org/article/032dd8c8b9bf4b20820beaeaca4308432018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03082-6https://doaj.org/toc/2041-1723Single nucleotide variants (SNVs) can affect chromatin occupancy by transcription factors (TF). Here the authors mine naturally occurring SNVs to probe cis elements and define contextual sequences that govern in vivo transcription factor chromatin occupancy and chromatin accessibility.Vivek BeheraPerry EvansCarolyne J. FaceNicole HamagamiLaavanya SankaranarayananCheryl A. KellerBelinda GiardineKai TanRoss C. HardisonJunwei ShiGerd A. BlobelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vivek Behera Perry Evans Carolyne J. Face Nicole Hamagami Laavanya Sankaranarayanan Cheryl A. Keller Belinda Giardine Kai Tan Ross C. Hardison Junwei Shi Gerd A. Blobel Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility
description	Single nucleotide variants (SNVs) can affect chromatin occupancy by transcription factors (TF). Here the authors mine naturally occurring SNVs to probe cis elements and define contextual sequences that govern in vivo transcription factor chromatin occupancy and chromatin accessibility.
format	article
author	Vivek Behera Perry Evans Carolyne J. Face Nicole Hamagami Laavanya Sankaranarayanan Cheryl A. Keller Belinda Giardine Kai Tan Ross C. Hardison Junwei Shi Gerd A. Blobel
author_facet	Vivek Behera Perry Evans Carolyne J. Face Nicole Hamagami Laavanya Sankaranarayanan Cheryl A. Keller Belinda Giardine Kai Tan Ross C. Hardison Junwei Shi Gerd A. Blobel
author_sort	Vivek Behera
title	Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility
title_short	Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility
title_full	Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility
title_fullStr	Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility
title_full_unstemmed	Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility
title_sort	exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/032dd8c8b9bf4b20820beaeaca430843
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Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility

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