Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility

Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility

Single nucleotide variants (SNVs) can affect chromatin occupancy by transcription factors (TF). Here the authors mine naturally occurring SNVs to probe cis elements and define contextual sequences that govern in vivo transcription factor chromatin occupancy and chromatin accessibility.

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Autores principales: Vivek Behera, Perry Evans, Carolyne J. Face, Nicole Hamagami, Laavanya Sankaranarayanan, Cheryl A. Keller, Belinda Giardine, Kai Tan, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/032dd8c8b9bf4b20820beaeaca430843
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