Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

Magnetic resonance-guided focused ultrasound with injected microbubbles has been used to temporarily open the blood–brain barrier (BBB) in animal models of Alzheimer's disease (AD). Here, the authors use this technology to non-invasively open the BBB in 5 patients with mild-to-moderate AD in a...

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Autores principales: Nir Lipsman, Ying Meng, Allison J. Bethune, Yuexi Huang, Benjamin Lam, Mario Masellis, Nathan Herrmann, Chinthaka Heyn, Isabelle Aubert, Alexandre Boutet, Gwenn S. Smith, Kullervo Hynynen, Sandra E. Black
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/032e903a864c4b94ba707f9db98faead
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spelling oai:doaj.org-article:032e903a864c4b94ba707f9db98faead2021-12-02T16:49:54ZBlood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound10.1038/s41467-018-04529-62041-1723https://doaj.org/article/032e903a864c4b94ba707f9db98faead2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04529-6https://doaj.org/toc/2041-1723Magnetic resonance-guided focused ultrasound with injected microbubbles has been used to temporarily open the blood–brain barrier (BBB) in animal models of Alzheimer's disease (AD). Here, the authors use this technology to non-invasively open the BBB in 5 patients with mild-to-moderate AD in a phase I trial, and show that the procedure is safe.Nir LipsmanYing MengAllison J. BethuneYuexi HuangBenjamin LamMario MasellisNathan HerrmannChinthaka HeynIsabelle AubertAlexandre BoutetGwenn S. SmithKullervo HynynenSandra E. BlackNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nir Lipsman
Ying Meng
Allison J. Bethune
Yuexi Huang
Benjamin Lam
Mario Masellis
Nathan Herrmann
Chinthaka Heyn
Isabelle Aubert
Alexandre Boutet
Gwenn S. Smith
Kullervo Hynynen
Sandra E. Black
Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
description Magnetic resonance-guided focused ultrasound with injected microbubbles has been used to temporarily open the blood–brain barrier (BBB) in animal models of Alzheimer's disease (AD). Here, the authors use this technology to non-invasively open the BBB in 5 patients with mild-to-moderate AD in a phase I trial, and show that the procedure is safe.
format article
author Nir Lipsman
Ying Meng
Allison J. Bethune
Yuexi Huang
Benjamin Lam
Mario Masellis
Nathan Herrmann
Chinthaka Heyn
Isabelle Aubert
Alexandre Boutet
Gwenn S. Smith
Kullervo Hynynen
Sandra E. Black
author_facet Nir Lipsman
Ying Meng
Allison J. Bethune
Yuexi Huang
Benjamin Lam
Mario Masellis
Nathan Herrmann
Chinthaka Heyn
Isabelle Aubert
Alexandre Boutet
Gwenn S. Smith
Kullervo Hynynen
Sandra E. Black
author_sort Nir Lipsman
title Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
title_short Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
title_full Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
title_fullStr Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
title_full_unstemmed Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
title_sort blood–brain barrier opening in alzheimer’s disease using mr-guided focused ultrasound
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/032e903a864c4b94ba707f9db98faead
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