Pooled testing with replication as a mass testing strategy for the COVID-19 pandemics

Abstract During the COVID-19 pandemic it is essential to test as many people as possible, in order to detect early outbreaks of the infection. Present testing solutions are based on the extraction of RNA from patients using oropharyngeal and nasopharyngeal swabs, and then testing with real-time PCR...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Julius Žilinskas, Algirdas Lančinskas, Mario R. Guarracino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/033327d43de140e0942fd3d913ec0e07
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:033327d43de140e0942fd3d913ec0e07
record_format	dspace
spelling	oai:doaj.org-article:033327d43de140e0942fd3d913ec0e072021-12-02T13:30:10ZPooled testing with replication as a mass testing strategy for the COVID-19 pandemics10.1038/s41598-021-83104-42045-2322https://doaj.org/article/033327d43de140e0942fd3d913ec0e072021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83104-4https://doaj.org/toc/2045-2322Abstract During the COVID-19 pandemic it is essential to test as many people as possible, in order to detect early outbreaks of the infection. Present testing solutions are based on the extraction of RNA from patients using oropharyngeal and nasopharyngeal swabs, and then testing with real-time PCR for the presence of specific RNA filaments identifying the virus. This approach is limited by the availability of reactants, trained technicians and laboratories. One of the ways to speed up the testing procedures is a group testing, where the swabs of multiple patients are grouped together and tested. In this paper we propose to use the group testing technique in conjunction with an advanced replication scheme in which each patient is allocated in two or more groups to reduce the total numbers of tests and to allow testing of even larger numbers of people. Under mild assumptions, a 13 × average reduction of tests can be achieved compared to individual testing without delay in time.Julius ŽilinskasAlgirdas LančinskasMario R. GuarracinoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julius Žilinskas Algirdas Lančinskas Mario R. Guarracino Pooled testing with replication as a mass testing strategy for the COVID-19 pandemics
description	Abstract During the COVID-19 pandemic it is essential to test as many people as possible, in order to detect early outbreaks of the infection. Present testing solutions are based on the extraction of RNA from patients using oropharyngeal and nasopharyngeal swabs, and then testing with real-time PCR for the presence of specific RNA filaments identifying the virus. This approach is limited by the availability of reactants, trained technicians and laboratories. One of the ways to speed up the testing procedures is a group testing, where the swabs of multiple patients are grouped together and tested. In this paper we propose to use the group testing technique in conjunction with an advanced replication scheme in which each patient is allocated in two or more groups to reduce the total numbers of tests and to allow testing of even larger numbers of people. Under mild assumptions, a 13 × average reduction of tests can be achieved compared to individual testing without delay in time.
format	article
author	Julius Žilinskas Algirdas Lančinskas Mario R. Guarracino
author_facet	Julius Žilinskas Algirdas Lančinskas Mario R. Guarracino
author_sort	Julius Žilinskas
title	Pooled testing with replication as a mass testing strategy for the COVID-19 pandemics
title_short	Pooled testing with replication as a mass testing strategy for the COVID-19 pandemics
title_full	Pooled testing with replication as a mass testing strategy for the COVID-19 pandemics
title_fullStr	Pooled testing with replication as a mass testing strategy for the COVID-19 pandemics
title_full_unstemmed	Pooled testing with replication as a mass testing strategy for the COVID-19 pandemics
title_sort	pooled testing with replication as a mass testing strategy for the covid-19 pandemics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/033327d43de140e0942fd3d913ec0e07
work_keys_str_mv	AT juliuszilinskas pooledtestingwithreplicationasamasstestingstrategyforthecovid19pandemics AT algirdaslancinskas pooledtestingwithreplicationasamasstestingstrategyforthecovid19pandemics AT mariorguarracino pooledtestingwithreplicationasamasstestingstrategyforthecovid19pandemics
_version_	1718392953388400640

Pooled testing with replication as a mass testing strategy for the COVID-19 pandemics

Ejemplares similares