DNA repair by Rad52 liquid droplets

Genome dynamics allow cells to repair DNA double-strand breaks (DSBs), which are highly toxic DNA lesions. Here the authors reveal that in S. cerevisiae, Rad52 DNA repair proteins assemble in liquid droplets that work with dynamic nuclear microtubules to relocalize lesions to the nuclear periphery f...

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Autores principales:	Roxanne Oshidari, Richard Huang, Maryam Medghalchi, Elizabeth Y. W. Tse, Nasser Ashgriz, Hyun O. Lee, Haley Wyatt, Karim Mekhail
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0334275f4fdc42f1b69c48d12f427599
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spelling	oai:doaj.org-article:0334275f4fdc42f1b69c48d12f4275992021-12-02T14:40:40ZDNA repair by Rad52 liquid droplets10.1038/s41467-020-14546-z2041-1723https://doaj.org/article/0334275f4fdc42f1b69c48d12f4275992020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14546-zhttps://doaj.org/toc/2041-1723Genome dynamics allow cells to repair DNA double-strand breaks (DSBs), which are highly toxic DNA lesions. Here the authors reveal that in S. cerevisiae, Rad52 DNA repair proteins assemble in liquid droplets that work with dynamic nuclear microtubules to relocalize lesions to the nuclear periphery for repair.Roxanne OshidariRichard HuangMaryam MedghalchiElizabeth Y. W. TseNasser AshgrizHyun O. LeeHaley WyattKarim MekhailNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roxanne Oshidari Richard Huang Maryam Medghalchi Elizabeth Y. W. Tse Nasser Ashgriz Hyun O. Lee Haley Wyatt Karim Mekhail DNA repair by Rad52 liquid droplets
description	Genome dynamics allow cells to repair DNA double-strand breaks (DSBs), which are highly toxic DNA lesions. Here the authors reveal that in S. cerevisiae, Rad52 DNA repair proteins assemble in liquid droplets that work with dynamic nuclear microtubules to relocalize lesions to the nuclear periphery for repair.
format	article
author	Roxanne Oshidari Richard Huang Maryam Medghalchi Elizabeth Y. W. Tse Nasser Ashgriz Hyun O. Lee Haley Wyatt Karim Mekhail
author_facet	Roxanne Oshidari Richard Huang Maryam Medghalchi Elizabeth Y. W. Tse Nasser Ashgriz Hyun O. Lee Haley Wyatt Karim Mekhail
author_sort	Roxanne Oshidari
title	DNA repair by Rad52 liquid droplets
title_short	DNA repair by Rad52 liquid droplets
title_full	DNA repair by Rad52 liquid droplets
title_fullStr	DNA repair by Rad52 liquid droplets
title_full_unstemmed	DNA repair by Rad52 liquid droplets
title_sort	dna repair by rad52 liquid droplets
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0334275f4fdc42f1b69c48d12f427599
work_keys_str_mv	AT roxanneoshidari dnarepairbyrad52liquiddroplets AT richardhuang dnarepairbyrad52liquiddroplets AT maryammedghalchi dnarepairbyrad52liquiddroplets AT elizabethywtse dnarepairbyrad52liquiddroplets AT nasserashgriz dnarepairbyrad52liquiddroplets AT hyunolee dnarepairbyrad52liquiddroplets AT haleywyatt dnarepairbyrad52liquiddroplets AT karimmekhail dnarepairbyrad52liquiddroplets
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DNA repair by Rad52 liquid droplets

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