Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study

Objectives: To evaluate the possible role of silodosin (a highly selective α1A-adrenoceptor antagonist) in facilitating the passage of distal ureteric stones (DUS) in children, as the role of α-blockers as medical expulsive therapy is well known in adults. Patients and methods: In all, 40 paediatric...

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Autores principales:	Hazem Elgalaly, Ahmed Eliwa, Mohamed Seleem, Emad Salem, Mohammed Omran, Haitham Shello, Khalid Abdelwahab, Salem Khalil, Mostafa Kamel
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2017
Materias:	Silodosin Distal ureteric stone (DUS) Children Medical expulsive therapy Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/033488164fa4467db0cca28978389fff
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spelling	oai:doaj.org-article:033488164fa4467db0cca28978389fff2021-12-02T10:12:19ZSilodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study2090-598X10.1016/j.aju.2017.05.005https://doaj.org/article/033488164fa4467db0cca28978389fff2017-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X17300712https://doaj.org/toc/2090-598XObjectives: To evaluate the possible role of silodosin (a highly selective α1A-adrenoceptor antagonist) in facilitating the passage of distal ureteric stones (DUS) in children, as the role of α-blockers as medical expulsive therapy is well known in adults. Patients and methods: In all, 40 paediatric patients (27 boys and 13 girls) diagnosed with unilateral, single, radiopaque DUS of <10 mm were included in the study. Their mean (SD, range) age was 8.1 (2.7, 5–17) years. The patients were randomly divided into two groups: Group A, received silodosin 4 mg as a single bedtime dose; and Group B, received placebo as a single bedtime dose. Ibuprofen was prescribed to both groups on-demand for pain episode relief. Patients were followed up biweekly for 4 weeks. The stone expulsion time and rate, pain episodes, analgesic use, and any adverse effects were recorded. Results: The mean (SD) stone size in Group A was 6.6 (1.7) mm and in Group B was 6.7 (1.4) mm (P = 0.4). Two patients were lost to follow-up (one from each group), and one patient in Group A refused to complete the study. The stone-free rate at end of the 4-week treatment period was 88.8% in Group A vs 73.6% in Group B (P = 0.4). The mean (SD) stone expulsion time was 7.0 (4.3) vs 10.4 (4.7) days in groups A and B, respectively (P = 0.02). The mean (SD) number of pain episodes requiring ibuprofen was 2.3 (1.4) vs 4.7 (2.6) episodes in groups A and B, respectively (P < 0.001). Adverse effects (headache and dizziness) were recorded in three patients (16.7%) in Group A, which were mild and none of them discontinued treatment, whilst no adverse effects were recorded in Group B. Conclusions: The data in the present study show that silodosin can be safely used in the treatment of DUS in children for decreasing time to stone expulsion, pain episodes, and analgesic requirement.Hazem ElgalalyAhmed EliwaMohamed SeleemEmad SalemMohammed OmranHaitham ShelloKhalid AbdelwahabSalem KhalilMostafa KamelTaylor & Francis GrouparticleSilodosinDistal ureteric stone (DUS)ChildrenMedical expulsive therapyDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 15, Iss 3, Pp 194-198 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Silodosin Distal ureteric stone (DUS) Children Medical expulsive therapy Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Silodosin Distal ureteric stone (DUS) Children Medical expulsive therapy Diseases of the genitourinary system. Urology RC870-923 Hazem Elgalaly Ahmed Eliwa Mohamed Seleem Emad Salem Mohammed Omran Haitham Shello Khalid Abdelwahab Salem Khalil Mostafa Kamel Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study
description	Objectives: To evaluate the possible role of silodosin (a highly selective α1A-adrenoceptor antagonist) in facilitating the passage of distal ureteric stones (DUS) in children, as the role of α-blockers as medical expulsive therapy is well known in adults. Patients and methods: In all, 40 paediatric patients (27 boys and 13 girls) diagnosed with unilateral, single, radiopaque DUS of <10 mm were included in the study. Their mean (SD, range) age was 8.1 (2.7, 5–17) years. The patients were randomly divided into two groups: Group A, received silodosin 4 mg as a single bedtime dose; and Group B, received placebo as a single bedtime dose. Ibuprofen was prescribed to both groups on-demand for pain episode relief. Patients were followed up biweekly for 4 weeks. The stone expulsion time and rate, pain episodes, analgesic use, and any adverse effects were recorded. Results: The mean (SD) stone size in Group A was 6.6 (1.7) mm and in Group B was 6.7 (1.4) mm (P = 0.4). Two patients were lost to follow-up (one from each group), and one patient in Group A refused to complete the study. The stone-free rate at end of the 4-week treatment period was 88.8% in Group A vs 73.6% in Group B (P = 0.4). The mean (SD) stone expulsion time was 7.0 (4.3) vs 10.4 (4.7) days in groups A and B, respectively (P = 0.02). The mean (SD) number of pain episodes requiring ibuprofen was 2.3 (1.4) vs 4.7 (2.6) episodes in groups A and B, respectively (P < 0.001). Adverse effects (headache and dizziness) were recorded in three patients (16.7%) in Group A, which were mild and none of them discontinued treatment, whilst no adverse effects were recorded in Group B. Conclusions: The data in the present study show that silodosin can be safely used in the treatment of DUS in children for decreasing time to stone expulsion, pain episodes, and analgesic requirement.
format	article
author	Hazem Elgalaly Ahmed Eliwa Mohamed Seleem Emad Salem Mohammed Omran Haitham Shello Khalid Abdelwahab Salem Khalil Mostafa Kamel
author_facet	Hazem Elgalaly Ahmed Eliwa Mohamed Seleem Emad Salem Mohammed Omran Haitham Shello Khalid Abdelwahab Salem Khalil Mostafa Kamel
author_sort	Hazem Elgalaly
title	Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study
title_short	Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study
title_full	Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study
title_fullStr	Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study
title_full_unstemmed	Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study
title_sort	silodosin in the treatment of distal ureteric stones in children: a prospective, randomised, placebo-controlled study
publisher	Taylor & Francis Group
publishDate	2017
url	https://doaj.org/article/033488164fa4467db0cca28978389fff
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Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study

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