Determinants of Virological Failure Among Patients on First-line Antiretroviral Therapy in Central Oromia, Ethiopia: A Case–Control Study

Determinants of Virological Failure Among Patients on First-line Antiretroviral Therapy in Central Oromia, Ethiopia: A Case–Control Study

Ilili Jemal Abdullahi,1 Haji Aman Deybasso,2 Abebe Megerso Adlo2 1ICAP Ethiopia Central Office, Addis Ababa, Ethiopia; 2Department of Public Health, Adama Hospital Medical College, Adama, Oromia, EthiopiaCorrespondence: Abebe Megerso Adlo Tel +251 911 04 45 25Email abemegerso@gmail.comBackground: Vi...

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Autores principales: Abdullahi IJ, Deybasso HA, Adlo AM
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
art
artcase–control
ethiopia
hiv
oromia
virological failure.
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/033510ce75ff496e82bad30a96338797
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spelling oai:doaj.org-article:033510ce75ff496e82bad30a963387972021-12-02T11:45:06ZDeterminants of Virological Failure Among Patients on First-line Antiretroviral Therapy in Central Oromia, Ethiopia: A Case–Control Study1179-1373https://doaj.org/article/033510ce75ff496e82bad30a963387972020-12-01T00:00:00Zhttps://www.dovepress.com/determinants-of-virological-failure-among-patients-on-first-line-antir-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Ilili Jemal Abdullahi,1 Haji Aman Deybasso,2 Abebe Megerso Adlo2 1ICAP Ethiopia Central Office, Addis Ababa, Ethiopia; 2Department of Public Health, Adama Hospital Medical College, Adama, Oromia, EthiopiaCorrespondence: Abebe Megerso Adlo Tel +251 911 04 45 25Email abemegerso@gmail.comBackground: Viral suppression among people living with HIV is the main goal of antiretroviral therapy (ART). Despite the treatment, more than four million people and over 55 thousand patients globally and in Ethiopia had virological failure respectively in 2017. The purpose of this study was to identify determinants of virological failure among patients on ART in central Oromia, Ethiopia.Methods: A facility-based unmatched case–control study was conducted. Sample size was calculated using EpiInfo software, and 504 randomly selected patient’s records were analyzed. Case to control ratio was one to one. Separate sampling frames were prepared for cases and controls using medical registration numbers (MRN) from patients’ registrations data. Cases and controls were selected from respective sampling frames. Respective patient charts were traced using the MRN, and data were extracted from patient charts using data abstraction format. The data were entered using EpiInfo version seven and analyzed using SPSS version 20.0. Descriptive statistics and binary logistic regression were used for the analysis. Adjusted odds ratio with its 95%CI was used to present strength association. A P-value of < 0.05 was used to determine statistical significance of the association.Results: Age < 15 years (AOR=3.72, 95%CI: 1.70– 8.12), baseline CD4 count < 100/mm3 (AOR=2.31, 95%CI: 1.05– 5.08), TDF-3TC-NVP regimen (AOR=2.81, 95%CI: 1.28– 6.18), nondisclosure of HIV status (AOR=6.78, 95%CI: 3.24– 14.15) and history of poor adherence (AOR=11.19, 95%CI: 5.65– 22.15) were factors independently associated with virological failure among the study participants.Conclusion: Younger age, low baseline CD4 count, TDF/NVP containing regimen, poor adherence, and nondisclosure of HIV status were significant determinants of virological failure. Therefore, adherence counseling and paying due attention to patients having these determinants are required to achieve adequate viral load suppression.Keywords: ART, ART case–control, Ethiopia, HIV, Oromia, virological failureAbdullahi IJDeybasso HAAdlo AMDove Medical Pressarticleartartcase–controlethiopiahivoromiavirological failure.Immunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 931-939 (2020)
institution DOAJ
collection DOAJ
language EN
topic art
artcase–control
ethiopia
hiv
oromia
virological failure.
Immunologic diseases. Allergy
RC581-607
spellingShingle art
artcase–control
ethiopia
hiv
oromia
virological failure.
Immunologic diseases. Allergy
RC581-607
Abdullahi IJ
Deybasso HA
Adlo AM
Determinants of Virological Failure Among Patients on First-line Antiretroviral Therapy in Central Oromia, Ethiopia: A Case–Control Study
description Ilili Jemal Abdullahi,1 Haji Aman Deybasso,2 Abebe Megerso Adlo2 1ICAP Ethiopia Central Office, Addis Ababa, Ethiopia; 2Department of Public Health, Adama Hospital Medical College, Adama, Oromia, EthiopiaCorrespondence: Abebe Megerso Adlo Tel +251 911 04 45 25Email abemegerso@gmail.comBackground: Viral suppression among people living with HIV is the main goal of antiretroviral therapy (ART). Despite the treatment, more than four million people and over 55 thousand patients globally and in Ethiopia had virological failure respectively in 2017. The purpose of this study was to identify determinants of virological failure among patients on ART in central Oromia, Ethiopia.Methods: A facility-based unmatched case–control study was conducted. Sample size was calculated using EpiInfo software, and 504 randomly selected patient’s records were analyzed. Case to control ratio was one to one. Separate sampling frames were prepared for cases and controls using medical registration numbers (MRN) from patients’ registrations data. Cases and controls were selected from respective sampling frames. Respective patient charts were traced using the MRN, and data were extracted from patient charts using data abstraction format. The data were entered using EpiInfo version seven and analyzed using SPSS version 20.0. Descriptive statistics and binary logistic regression were used for the analysis. Adjusted odds ratio with its 95%CI was used to present strength association. A P-value of < 0.05 was used to determine statistical significance of the association.Results: Age < 15 years (AOR=3.72, 95%CI: 1.70– 8.12), baseline CD4 count < 100/mm3 (AOR=2.31, 95%CI: 1.05– 5.08), TDF-3TC-NVP regimen (AOR=2.81, 95%CI: 1.28– 6.18), nondisclosure of HIV status (AOR=6.78, 95%CI: 3.24– 14.15) and history of poor adherence (AOR=11.19, 95%CI: 5.65– 22.15) were factors independently associated with virological failure among the study participants.Conclusion: Younger age, low baseline CD4 count, TDF/NVP containing regimen, poor adherence, and nondisclosure of HIV status were significant determinants of virological failure. Therefore, adherence counseling and paying due attention to patients having these determinants are required to achieve adequate viral load suppression.Keywords: ART, ART case–control, Ethiopia, HIV, Oromia, virological failure
format article
author Abdullahi IJ
Deybasso HA
Adlo AM
author_facet Abdullahi IJ
Deybasso HA
Adlo AM
author_sort Abdullahi IJ
title Determinants of Virological Failure Among Patients on First-line Antiretroviral Therapy in Central Oromia, Ethiopia: A Case–Control Study
title_short Determinants of Virological Failure Among Patients on First-line Antiretroviral Therapy in Central Oromia, Ethiopia: A Case–Control Study
title_full Determinants of Virological Failure Among Patients on First-line Antiretroviral Therapy in Central Oromia, Ethiopia: A Case–Control Study
title_fullStr Determinants of Virological Failure Among Patients on First-line Antiretroviral Therapy in Central Oromia, Ethiopia: A Case–Control Study
title_full_unstemmed Determinants of Virological Failure Among Patients on First-line Antiretroviral Therapy in Central Oromia, Ethiopia: A Case–Control Study
title_sort determinants of virological failure among patients on first-line antiretroviral therapy in central oromia, ethiopia: a case–control study
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/033510ce75ff496e82bad30a96338797
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AT adloam determinantsofvirologicalfailureamongpatientsonfirstlineantiretroviraltherapyincentraloromiaethiopiaacasendashcontrolstudy
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